Lab Information

Erwin Schurr (PhD)

Senior Scientist
Centre for Translational Biology
Department of Human Genetics (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Tuberculosis • leprosy • complex traits • transcriptomics • systems biology

Research Interests

My research focuses on the identification and evaluation of host genetic factors in tuberculosis and leprosy. We are working with partner groups in endemic countries for those diseases and are applying modern concepts of genetics, genomics and sytems biology to our analyses.

Team Members

Name Position

Latest Publications

  1. Fava, V. M., Bourgey, M., Nawarathna, P. M., Orlova, M., Cassart, P., Vinh, D. C., Cheng, M. P., Bourque, G., Schurr, E. & Langlais, D. (2022). A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19. Science advances, vol. 8, p. eabm2510.
  2. Fava, V. M., Dallmann-Sauer, M., Orlova, M., Correa-Macedo, W., Van Thuc, N., Thai, V. H., Alcaïs, A., Abel, L., Cobat, A. & Schurr, E. (2021). Deep resequencing identifies candidate functional genes in leprosy GWAS loci. PLoS neglected tropical diseases, vol. 15, p. e0010029.
  3. Correa-Macedo, W., Fava, V. M., Orlova, M., Cassart, P., Olivenstein, R., Sanz, J., Xu, Y. Z., Dumaine, A., Sindeaux, R. H., Yotova, V., Pacis, A., Girouard, J., Kalsdorf, B., Lange, C., Routy, J.-P., Barreiro, L. B. & Schurr, E. (2021). Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis. The Journal of clinical investigation, vol. 131.
  4. Dubé, J.-Y., Fava, V. M., Schurr, E. & Behr, M. A. (2021). Underwhelming or Misunderstood? Genetic Variability of Pattern Recognition Receptors in Immune Responses and Resistance to Mycobacterium tuberculosis. Frontiers in immunology, vol. 12, p. 714808.
  5. Kontsevaya, I., Lange, C., Comella-Del-Barrio, P., Coarfa, C., DiNardo, A. R., Gillespie, S. H., Hauptmann, M., Leschczyk, C., Mandalakas, A. M., Martinecz, A., Merker, M., Niemann, S., Reimann, M., Rzhepishevska, O., Schaible, U. E., Scheu, K. M., Schurr, E., Abel Zur Wiesch, P. & Heyckendorf, J. (2021). Perspectives for systems biology in the management of tuberculosis. European respiratory review : an official journal of the European Respiratory Society, vol. 30.
  6. Quistrebert, J., Orlova, M., Kerner, G., Ton, L. T., Luong, N. T., Danh, N. T., Vincent, Q. B., Jabot-Hanin, F., Seeleuthner, Y., Bustamante, J., Boisson-Dupuis, S., Huong, N. T., Ba, N. N., Casanova, J.-L., Delacourt, C., Hoal, E. G., Alcaïs, A., Thai, V. H., Thành, L. T., Abel, L., Schurr, E. & Cobat, A. (2021). Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations. PLoS genetics, vol. 17, p. e1009392.
  7. Behr, M. A., Divangahi, M. & Schurr, E. (2021). Lessons From Bacille Calmette-Guérin for SARS-CoV-2 Vaccine Candidates. The Journal of infectious diseases, vol. 223, p. 189-191.
  8. Cheng, A. P., Cheng, M. P., Gu, W., Sesing Lenz, J., Hsu, E., Schurr, E., Bourque, G., Bourgey, M., Ritz, J., Marty, F. M., Chiu, C. Y., Vinh, D. C. & De Vlaminck, I. (2021). Cell-free DNA tissues of origin by methylation profiling reveals significant cell, tissue, and organ-specific injury related to COVID-19 severity. Med (New York, N.Y.), vol. 2, p. 411-422.e5.
  9. Meziane, O., Alexandrova, Y., Olivenstein, R., Dupuy, F. P., Salahuddin, S., Thomson, E., Orlova, M., Schurr, E., Ancuta, P., Durand, M., Chomont, N., Estaquier, J., Bernard, N. F., Costiniuk, C. T. & Jenabian, M.-A. (2021). Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy. Journal of immunology (Baltimore, Md. : 1950), vol. 206, p. 641-651.
  10. Kroon, E. E., Kinnear, C. J., Orlova, M., Fischinger, S., Shin, S., Boolay, S., Walzl, G., Jacobs, A., Wilkinson, R. J., Alter, G., Schurr, E., Hoal, E. G. & Möller, M. (2020). An observational study identifying highly tuberculosis-exposed, HIV-1-positive but persistently TB, tuberculin and IGRA negative persons with M. tuberculosis specific antibodies in Cape Town, South Africa. EBioMedicine, vol. 61, p. 103053.
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