Lab Information
Erwin Schurr (PhD)
Senior ScientistCentre for Translational Biology
Department of Human Genetics (McGill)
Research Profile
Keywords
Tuberculosis • leprosy • complex traits • transcriptomics • systems biologyResearch Interests
My research focuses on the identification and evaluation of host genetic factors in tuberculosis and leprosy. We are working with partner groups in endemic countries for those diseases and are applying modern concepts of genetics, genomics and sytems biology to our analyses.Team Members
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Latest Publications
- Fahmy, A. M., Ahmadi, A., Lanoix, J., Cannon, T., Elemeery, M. N., Paredes, C. H., Barrette, B., Bonneil, E., Xu, Y. Z., Ibrahim, M., Arango-Duque, G., Audemard, E. O., Lemieux, S., Chevet, E., Schurr, E., Pierre, P., Gruenheid, S., Thibault, P., McBride, H. M. & Desjardins, M. (2026). STING dampens the unfolded protein response to enable the presentation of self-antigens on MHC-I during inflammation. Cell reports, vol. 45, p. 117497.
- Goldman, A., Nguyen, M., Lanoix, J., Li, C., Fahmy, A., Xu, Y. Z., Schurr, E., Thibault, P., Desjardins, M. & McBride, H. M. (2026). LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death. Journal of cell science.
- Fava, V. M., Dallmann-Sauer, M., Orlova, M., Correa-Macedo, W., Olivenstein, R., Costiniuk, C. T., Routy, J.-P., Barreiro, L. B. & Schurr, E. (2026). Continuous antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages. Frontiers in immunology, vol. 17, p. 1805936.
- Dallmann-Sauer, M., Xu, Y. Z., Correa-Macedo, W., Orlova, M. & Schurr, E. (2026). Tissue-specific transcriptional epistasis between Prkn and Lrrk2 during mycobacterial infection. Mammalian genome : official journal of the International Mammalian Genome Society, vol. 37.
- Tulu, B., Brehm, T. T., van Crevel, R., Dallenga, T., DiNardo, A. R., Dheda, K., Eggeling, J., Enbiale, W., Gröschel, M. I., Hao, J., Kumar, V., van Laarhoven, A., Londt, R., Prosser, G., Randall, P., Reiling, N., Rybniker, J., Schaible, U. E., Schurr, E., Suarez, I., Theobald, S. J., Wilkinson, R. J. & Lange, C. (2026). Host- and pathogen-related determinants of pulmonary versus extrapulmonary tuberculosis. European respiratory review : an official journal of the European Respiratory Society, vol. 35.
- Fava, V. M., Perico, J., Orlova, M., Dallmann-Sauer, M., Xu, Y. Z., Thuc, N. V., Thai, V. H., Belone, A. F., Latini, A. C. P. & Schurr, E. (2025). Bridging pleiotropic mechanisms in leprosy type-1 reactions and neurodegenerative diseases. Scientific reports, vol. 15, p. 45036.
- Conil, C., Bohlen, J., Kroon, E. E., Jean-Juste, M. A., Manry, J., Chaldebas, M., Bean, J. M., Walsh, K. F., Dallmann-Sauer, M., Rotival, M., Seeleuthner, Y., Marchal, A., Mourelatos, H., Fava, V. M., Zhang, P., Kerner, G., Skhoun, H., Abid, A., El Ouazzani, H., Rafik, A., Bousfiha, A. A., El Baghdadi, J., Wilkinson, R. J., Boisson-Dupuis, S., Fitzgerald, D. W., Pape, J. W., Möller, M., Hoal, E. G., Casanova, J.-L., Abel, L., Schurr, E. & Cobat, A. (2025). A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure. Genome medicine, vol. 17, p. 121.
- de Oliveira Mackert, C. C., Lázaro, F. P., Olandowski, M., D'Espindula, H. R. S., Dos Santos, A. M., Sartori, P. V. U., de Andrade Rodrigues, R. S., Cambri, G., Xavier, M. B., Schurr, E., Alcaïs, A. & Mira, M. T. (2025). Insights into leprosy epidemiology from an isolated population located in the Brazilian Amazon. Scientific reports, vol. 15, p. 6103.
- Dallmann-Sauer, M., Fava, V. M., Malherbe, S. T., MacDonald, C. E., Orlova, M., Kroon, E. E., Cobat, A., Boisson-Dupuis, S., Hoal, E. G., Abel, L., Möller, M., Casanova, J.-L., Walzl, G., Du Plessis, N. & Schurr, E. (2025). Mycobacterium tuberculosis resisters despite HIV exhibit activated T cells and macrophages in their pulmonary alveoli. The Journal of clinical investigation, vol. 135.
- Brehm, T. T., Köhler, N., Grobbel, H.-P., Welling, J., Mandalakas, A. M., Fava, V., Schurr, E. & Lange, C. (2025). High risk of drug-resistant tuberculosis in IGRA-negative contacts: should preventive treatment be considered?. Infection, vol. 53, p. 1501-1506.
See also
