Lab Information
Jean-Pierre Routy (MD)
Senior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
HIV • chronic viral infections • CMV • HHV8 • HIV reservoirs • gutResearch Interests
My research focuses on human immunodeficiency virus (HIV) pathogenesis aiming at finding an HIV cure. Improving knowledge in immune tolerance in cancer and immunometabolism will be key to developing strategy to conquer cancers and auto-immune diseases.Team Members
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Latest Publications
- Ramani, H., Cleret-Buhot, A., Sylla, M., Bunet, R., Bertrand, F., Peet, M.-M., Chartrand-Lefebvre, C., Trottier, B., Thomas, R., Routy, J.-P., Fortin, C., Martel-Laferrière, V., Sadouni, M., Cloutier, G., Allard, L., Kizer, J. R., Chomont, N., Ancuta, P., Hanna, D. B., Kaplan, R. C., Jenabian, M.-A., Landay, A. L., Durand, M., El-Far, M. & Tremblay, C. L. (2025). Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV. Cells, vol. 14.
- Vulesevic, B., Lu, J., Lauscher, D., Shelton, B., Dubé, K., Routy, J.-P., Berini, C. & Costiniuk, C. T. (2025). Awareness and willingness regarding organ donation among people with HIV in Canada. AIDS care, p. 1-11.
- Nayyerabadi, M., Fourcade, L., Joshi, S. A., Chandrasekaran, P., Chakravarti, A., Massé, C., Paul, M.-L., Houle, J., Boubekeur, A. M., DuSablon, C., Boudreau, V., Bovan, D., Darbinian, E., Coleman, E. A., Vinci, S., Routy, J.-P., Hétu, P.-O., Poudrier, J. & Falcone, E. L. (2025). Corrigendum to "Vaccination after developing long COVID: Impact on clinical presentation, viral persistence and immune responses" [International Journal of Infectious Diseases, volume 136 (2023), 136-145, doi:10.1016/j.ijid.2023.09.006]. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, vol. 153, p. 107842.
- Isnard, S., Mabanga, T., Royston, L., Berini, C. A., Bu, S., Aiyana, O., Feng, H., Lebouché, B., Costiniuk, C. T., Cox, J., Kroemer, G., Durand, M., Routy, J.-P. & Biobanque Québécoise de la COVID-19 (BQC-19) (2024). Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity. Frontiers in immunology, vol. 15, p. 1505752.
- Ghahari, N., Shegefti, S., Alaei, M., Amara, A., Telittchenko, R., Isnard, S., Routy, J.-P., Olagnier, D. & van Grevenynghe, J. (2024). HSP60 controls mitochondrial ATP generation for optimal virus-specific IL-21-producing CD4 and cytotoxic CD8 memory T cell responses. Communications biology, vol. 7, p. 1688.
- Bitektine, E., Hagh-Daoust, H., Michel, R. P., Isnard, S. & Routy, J.-P. (2024). The Value of a Pet Scan in Selecting the Best Lymph Node to Biopsy, and Confirming the Diagnosis of Idiopathic Multicentric Castleman Disease with HLH And EBV Viremia in a Previously Healthy Adult. European journal of case reports in internal medicine, vol. 11, p. 004908.
- Xiong, Y., Xiang, D., Zhou, X., Huang, Y., Routy, J.-P. & Zhu, B. (2024). Application of metagenomic next-generation sequencing with brain tissue biopsy for diagnosing intracranial lesions in people with HIV. Precision clinical medicine, vol. 7, p. pbae029.
- Magombedze, G., Vendrame, E., SenGupta, D., Geleziunas, R., Little, S., Smith, D., Walker, B., Routy, J.-P., Hecht, F. M., Chun, T.-W., Sneller, M., Li, J. Z., Deeks, S. G. & Peluso, M. J. (2025). Early Viral Dynamics Predict HIV Post-Treatment Control After Analytic Treatment Interruption. The Journal of infectious diseases, vol. 231, p. e419-e428.
- Yero, A., Shi, T., Clain, J. A., Zghidi-Abouzid, O., Racine, G., Costiniuk, C. T., Routy, J.-P., Estaquier, J. & Jenabian, M.-A. (2024). Double-Negative T-Cells during Acute Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections and Following Early Antiretroviral Therapy Initiation. Viruses, vol. 16.
- Kabakibo, T. S., Arnold, E., Padhan, K., Lemieux, A., Ortega-Delgado, G. G., Routy, J.-P., Shoukry, N., Dubé, M. & Kaufmann, D. E. (2024). Artificial antigen-presenting cell system reveals CD28's role in modulating T cell functions during human immunodeficiency virus infection. iScience, vol. 27, p. 110947.
See also
