Lab Information
Jean-Pierre Routy (MD)
Senior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
HIV • chronic viral infections • CMV • HHV8 • HIV reservoirs • gutResearch Interests
My research focuses on human immunodeficiency virus (HIV) pathogenesis aiming at finding an HIV cure. Improving knowledge in immune tolerance in cancer and immunometabolism will be key to developing strategy to conquer cancers and auto-immune diseases.Team Members
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Latest Publications
- Xiong, Y., Xiang, D., Zhou, X., Huang, Y., Routy, J.-P. & Zhu, B. (2024). Application of metagenomic next-generation sequencing with brain tissue biopsy for diagnosing intracranial lesions in people with HIV. Precision clinical medicine, vol. 7, p. pbae029.
- Magombedze, G., Vendrame, E., SenGupta, D., Geleziunas, R., Little, S., Smith, D., Walker, B., Routy, J.-P., Hecht, F. M., Chun, T.-W., Sneller, M., Li, J. Z., Deeks, S. G. & Peluso, M. J. (2024). Early Viral Dynamics Predict HIV Post-Treatment Control After Analytic Treatment Interruption. The Journal of infectious diseases.
- Yero, A., Shi, T., Clain, J. A., Zghidi-Abouzid, O., Racine, G., Costiniuk, C. T., Routy, J.-P., Estaquier, J. & Jenabian, M.-A. (2024). Double-Negative T-Cells during Acute Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections and Following Early Antiretroviral Therapy Initiation. Viruses, vol. 16.
- Kabakibo, T. S., Arnold, E., Padhan, K., Lemieux, A., Ortega-Delgado, G. G., Routy, J.-P., Shoukry, N., Dubé, M. & Kaufmann, D. E. (2024). Artificial antigen-presenting cell system reveals CD28's role in modulating T cell functions during human immunodeficiency virus infection. iScience, vol. 27, p. 110947.
- Fert, A., Richard, J., Raymond Marchand, L., Planas, D., Routy, J.-P., Chomont, N., Finzi, A. & Ancuta, P. (2024). Metformin facilitates viral reservoir reactivation and their recognition by anti-HIV-1 envelope antibodies. iScience, vol. 27, p. 110670.
- Wu, L., Zheng, Z., Xun, J., Liu, L., Wang, J., Zhang, X., Shao, Y., Shen, Y., Zhang, R., Zhang, M., Sun, M., Qi, T., Wang, Z., Xu, S., Song, W., Tang, Y., Zhao, B., Song, Z., Routy, J.-P., Lu, H. & Chen, J. (2024). Anti-PD-L1 antibody ASC22 in combination with a histone deacetylase inhibitor chidamide as a "shock and kill" strategy for ART-free virological control: a phase II single-arm study. Signal transduction and targeted therapy, vol. 9, p. 231.
- Brenner, B. G., Ibanescu, R.-I., Oliveira, M., Margaillan, G., Lebouché, B., Thomas, R., Baril, J. G., Lorgeoux, R.-P., Roger, M., Routy, J.-P. & (2024). Phylogenetic Network Analyses Reveal the Influence of Transmission Clustering on the Spread of HIV Drug Resistance in Quebec from 2002 to 2022. Viruses, vol. 16.
- Yero, A., Goulet, J.-P., Shi, T., Costiniuk, C. T., Routy, J.-P., Tremblay, C., Mboumba Bouassa, R.-S., Alexandrova, Y., Pagliuzza, A., Chomont, N., Ancuta, P. & Jenabian, M.-A. (2024). Altered memory CCR6+ Th17-polarised T-cell function and biology in people with HIV under successful antiretroviral therapy and HIV elite controllers. EBioMedicine, vol. 107, p. 105274.
- Royston, L., Jary, A., Berini, C. A., Mabanga, T., Lin, J., Pagliuzza, A., Chomont, N., Litvinov, I. V., Calmy, A., Leducq, V., Calvez, V., Marcelin, A.-G., Isnard, S. & Routy, J.-P. (2024). Similar Viral and Immune Characteristics of Kaposi Sarcoma in ART-treated People Living With HIV and Older Patients With Classic Kaposi Sarcoma. Open forum infectious diseases, vol. 11, p. ofae404.
- Mboumba Bouassa, R.-S., Needham, J., Nohynek, D., Samarani, S., Bobeuf, F., Del Balso, L., Paisible, N., Vertzagias, C., Sebastiani, G., Margolese, S., Mandarino, E., Singer, J., Klein, M., Lebouché, B., Cox, J., Vulesevic, B., Müller, A., Lau, E., Routy, J.-P., Jenabian, M.-A. & Costiniuk, C. T. (2024). Feasibility of a Randomized, Interventional Pilot Clinical Study of Oral Cannabinoids in People with HIV on Antiretroviral Therapy: CTNPT 028. Journal of personalized medicine, vol. 14.
See also
