Lab Information

Jean-Pierre Routy (MD)

Senior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 50%
 Clinical: 50%
 Epidemiology: 0%
 Evaluation: 0%
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HIV • vaccine • lymphoma • T cells • cytokines

Research Interests

My research focuses on HIV pathogenesis aiming at finding an HIV cure. Improving knowledge in immune tolerance in cancer and in immune privileged sites (central nervous system, testis) will be key to develop strategy to conquer cancers and auto-immune diseases.

Team Members

Name Position

Latest Publications

  1. Long, C., Al-Abdulmalek, A., Lai, J., Haegert, D. G., Isnard, S., Cournoyer, D. & Routy, J.-P. (2024). Haemophagocytic Lymphohistiocytosis Following the anti-PD-1 Nivolumab in a Patient with Gastric Cancer and Ankylosing Spondylitis. European journal of case reports in internal medicine, vol. 11, p. 004370.
  2. Bu, S., Royston, L., Mabanga, T., Berini, C. A., Tremblay, C., Lebouché, B., Cox, J., Costiniuk, C. T., Durand, M., Isnard, S. & Routy, J.-P. (2024). Proteomics validate circulating GDF-15 as an independent biomarker for COVID-19 severity. Frontiers in immunology, vol. 15, p. 1377126.
  3. Mehraj, V., Chen, J. & Routy, J.-P. (2024). Effects of statins beyond lipid-lowering agents in ART-treated HIV infection. Frontiers in immunology, vol. 15, p. 1339338.
  4. Fert, A., Richard, J., Marchand, L. R., Planas, D., Routy, J.-P., Chomont, N., Finzi, A. & Ancuta, P. (2024). Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4+ T-Cells by Decreasing Viral Release. bioRxiv : the preprint server for biology.
  5. De Wit, S., Bonnet, F., Osiyemi, O., Bisshop, F., Olalla, J., Routy, J.-P., Wyen, C., Moodley, R., Pappa, K., Wang, R., Oyee, J., Saggu, P., Letang, E., Wynne, B., Jones, B., Smith, K. Y. & Ait-Khaled, M. (2024). Durable Efficacy of Switching From a 3- or 4-Drug Tenofovir Alafenamide-Based Regimen to the 2-Drug Regimen Dolutegravir/Lamivudine in the TANGO Study Through Week 196. Journal of acquired immune deficiency syndromes (1999).
  6. Anand, A., Vialard, F., Esmail, A., Ahmad Khan, F., O'Byrne, P., Routy, J.-P., Dheda, K. & Pant Pai, N. (2024). Self-tests for COVID-19: What is the evidence? A living systematic review and meta-analysis (2020-2023). PLOS global public health, vol. 4, p. e0002336.
  7. Doyon-Laliberté, K., Aranguren, M., Chagnon-Choquet, J., Batraville, L.-A., Dagher, O., Richard, J., Paniconi, M., Routy, J.-P., Tremblay, C., Quintal, M.-C., Brassard, N., Kaufmann, D. E., Finzi, A., Poudrier, J. & Roger, M. (2023). Excess BAFF May Impact HIV-1-Specific Antibodies and May Promote Polyclonal Responses Including Those from First-Line Marginal Zone B-Cell Populations. Current issues in molecular biology, vol. 46, p. 25-43.
  8. Wiche Salinas, T. R., Zhang, Y., Gosselin, A., Rosario, N. F., El-Far, M., Filali-Mouhim, A., Routy, J.-P., Chartrand-Lefebvre, C., Landay, A. L., Durand, M., Tremblay, C. L., Ancuta, P. & Canadian HIV and Aging Cohort Study (CHACS) (2024). Alterations in Th17 Cells and Non-Classical Monocytes as a Signature of Subclinical Coronary Artery Atherosclerosis during ART-Treated HIV-1 Infection. Cells, vol. 13.
  9. Arora, A. K., Vicente, S., Engler, K., Lessard, D., Huerta, E., Ishak, J., Routy, J.-P., Klein, M., Kronfli, N., Cox, J., Lemire, B., de Pokomandy, A., Del Balso, L., Sebastiani, G., Vedel, I., Quesnel-Vallée, A., ASAP Migrant Advisory Committee & Lebouché, B. (2024). Impact of social determinants of health on time to antiretroviral therapy initiation and HIV viral undetectability for migrants enrolled in a multidisciplinary HIV clinic with rapid, free, and onsite B/F/TAF: 'The ASAP study'. HIV medicine, vol. 25, p. 600-607.
  10. Ramani, H., Gosselin, A., Bunet, R., Jenabian, M. A., Sylla, M., Pagliuzza, A., Chartrand-Lefebvre, C., Routy, J. P., Goulet, J. P., Thomas, R., Trottier, B., Martel-Laferrière, V., Fortin, C., Chomont, N., Fromentin, R., Landay, A., Durand, M., Ancuta, P., El-Far, M. & Tremblay, C. (2024). IL-32 Drives the Differentiation of Cardiotropic CD4+ T-Cells Carrying HIV DNA in People Living with HIV. The Journal of infectious diseases, vol. 229, p. 1277-1289.
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De Pokomandy

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