Lab Information

Bertrand Lebouché (MD/PhD)

Centre for Outcomes Research and Evaluation
Department of Family Medicine (McGill)

Research Profile

 Fundamental: 0%
 Clinical: 60%
 Epidemiology: 0%
 Evaluation: 40%
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HIV • adherence • antiretroviral therapy • patient engagement • patient-reported outcome measures • mHealth • HCV • men who have sex with men • HIV prevention

Research Interests

My research focuses on three main axes, drawing on a multidisciplinary model of care and a patient-oriented perspective. First of all, I study HIV/STI testing. Fifteen percent of PLHIV in Canada are undiagnosed. I examined the impact of a community-based rapid HIV-testing site with nurse and community agent teams on attracting vulnerable groups, linking them to care and service appreciation. Secondly, I study sexual health and antiretroviral therapy (ART) as prevention. Sexual health issues in HIV-positive MSM regularly go unaddressed. With parallel studies, I will examine the effect of a sex therapist-led intervention on their adherence, transmission risk, and broader sexual health. Thirdly, I study Optimizing ART. Innovative clinical monitoring tools are needed to detect factors that could interfere with ART adherence early. My I-Score Study will generate an electronic patient-reported outcome measure for use in routine HIV care towards more patient-centered care.

Team Members

Name Position

Latest Publications

  1. Benmassaoud, A., Macias, J., Delamarre, A., Corma-Gomez, A., Guaraldi, G., Milic, J., Rockstroh, J. K., Van Bremen, K., Tsochatzis, E., Mulay, A., Price, J., Garvey, L. J., Lemoine, M., Kablawi, D., Lebouche, B., Klein, M. B., Ballesteros, L. R., Boesecke, C., Schepis, F., Bhagani, S., Cooke, G., Berzigotti, A., Hirose, K., Pineda, J. A., Ramanakumar, A. V., De-Ledinghen, V., Saeed, S. & Sebastiani, G. (2023). Prognostic value of non-invasive scores based on liver stiffness measurement, spleen diameter and platelets in HIV-infected patients. Liver international : official journal of the International Association for the Study of the Liver.
  2. Mate, K. K. V., Engler, K., Lessard, D. & Lebouché, B. (2023). Barriers to adherence to antiretroviral therapy: identifying priority areas for people with HIV and healthcare professionals. International journal of STD & AIDS, p. 9564624231169329.
  3. Lanièce Delaunay, C., Klein, M. B., Godin, A., Cox, J., Kronfli, N., Lebouché, B., Doyle, C. & Maheu-Giroux, M. (2023). Public health interventions, priority populations, and the impact of COVID-19 disruptions on hepatitis C elimination among people who have injected drugs in Montreal (Canada): A modeling study. The International journal on drug policy, vol. 116, p. 104026.
  4. Sebastiani, G., Milic, J., Kablawi, D., Gioe', C., Al Hinai, A. S., Lebouché, B., Tsochatzis, E., Finkel, J., Ballesteros, L. R., Ramanakumar, A. V., Bhagani, S., Benmassaoud, A., Mazzola, G., Cascio, A. & Guaraldi, G. (2023). Fibroscan-aspartate aminotransferase (FAST) score predicts liver-related outcomes, but not extra-hepatic events, in a multicenter cohort of people with HIV. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
  5. Yang, M., Daftary, A., Mendelsohn, J. B., Ryan, M., Bullock, S., Bisaillon, L., Bourne, A., Lebouché, B., Thompson, T. & Calzavara, L. (2023). "Live a normal life": Constructions of resilience among people in mixed HIV status relationships in Canada. PloS one, vol. 18, p. e0281301.
  6. Royston, L., Isnard, S., Berini, C. A., Bu, S., Lakatos, P. L., Bessissow, T., Chomont, N., Klein, M., Lebouché, B., de Pokomandy, A., Kronfli, N., Costiniuk, C. T., Thomas, R., Tremblay, C., Boivin, G. & Routy, J.-P. (2023). Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral therapy: protocol of the open-label controlled randomised CIAO study. BMJ open, vol. 13, p. e067640.
  7. Mate, K. K. V., Lebouché, B., Brouillette, M.-J., Fellows, L. K. & Mayo, N. E. (2022). Development of a Prototype for a Bilingual Patient-Reported Outcome Measure of the Important Health Aspects of Quality of Life in People Living with HIV: The Preference Based HIV Index (PB-HIV). Journal of personalized medicine, vol. 12.
  8. Mboumba Bouassa, R.-S., Needham, J., Nohynek, D., Singer, J., Lee, T., Bobeuf, F., Samarani, S., Del Balso, L., Paisible, N., Vertzagias, C., Sebastiani, G., Margolese, S., Mandarino, E., Klein, M., Lebouché, B., Cox, J., Brouillette, M.-J., Routy, J.-P., Szabo, J., Thomas, R., Huchet, E., Vigano, A., Jenabian, M.-A. & Costiniuk, C. T. (2022). Safety and Tolerability of Oral Cannabinoids in People Living with HIV on Long-Term ART: A Randomized, Open-Label, Interventional Pilot Clinical Trial (CTNPT 028). Biomedicines, vol. 10.
  9. Klein, M. B., Young, J., Ortiz-Paredes, D., Wang, S., Walmsley, S., Wong, A., Martel-Laferrière, V., Pick, N., Conway, B., Angel, J., Baril, J.-G., Fraser, C., Lebouché, B., Tan, D. H. S., Sandre, R., Trottier, S., Peiris, H., Jayaraman, J., Singer, J. & CTN 286 Study Investigators (2022). Virological Outcomes After Switching to Abacavir/Lamivudine/Dolutegravir Combined with Adherence Support in People Living with HIV with Poor Adherence: A Phase IV, Multicentre Randomized Prospective Open Label Study (TriiADD-CTN 286). Patient preference and adherence, vol. 16, p. 3267-3281.
  10. Costiniuk, C. T., Singer, J., Lee, T., Langlois, M.-A., Arnold, C., Galipeau, Y., Needham, J., Kulic, I., Jenabian, M.-A., Burchell, A. N., Shamji, H., Chambers, C., Walmsley, S., Ostrowski, M., Kovacs, C., Tan, D. H. S., Harris, M., Hull, M., Brumme, Z. L., Lapointe, H. R., Brockman, M. A., Margolese, S., Mandarino, E., Samarani, S., Vulesevic, B., Lebouché, B., Angel, J. B., Routy, J.-P., Cooper, C. L., Anis, A. H. & COVAXHIV Study Group (2023). COVID-19 vaccine immunogenicity in people with HIV. AIDS (London, England), vol. 37, p. F1-F10.
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