Lab Information
Giada Sebastiani (MD)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
Keywords
Fatty liver • serum liver biomarkers • elastography • HIV • hepatitis C • hepatitis BResearch Interests
My research focuses on screening for liver fibrosis and fatty liver of at-risk populations, including HIV+ patients, patients with diabetes and obesity, women with polycystic ovary syndrome, and patients with inflammatory bowel syndrome. To conduct these studies, I employ serum fibrosis biomarkers and a non-invasive machine, which is ultrasound-based, named Fibroscan. I am also site investigator of multiple global clinical trials for antifibrotic compounds in NASH.Team Members
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Latest Publications
- Kosick, H.-M., McIntosh, C., Bera, C., Fakhriyehasl, M., Shengir, M., Adeyi, O., Amiri, L., Sebastiani, G., Jhaveri, K. & Patel, K. (2025). Machine learning models using non-invasive tests & B-mode ultrasound to predict liver-related outcomes in metabolic dysfunction-associated steatotic liver disease. Scientific reports, vol. 15, p. 24579.
- Pennisi, G., Di Maria, G., Wai-Sun Wong, V., de Ledinghen, V., Sebastiani, G., Viganò, M., Fracanzani, A. L., Miele, L., Bugianesi, E., Ekstedt, M., D'Ambrosio, R., Ravaioli, F., Schepis, F., Marra, F., Aghemo, A., Svegliati-Baroni, G., Persico, M., Valenti, L., Berzigotti, A., George, J., Armandi, A., Nasr, P., Kechagias, S., Liguori, A., Saltini, D., Mendoza, Y. P., Calvaruso, V., Enea, M., Lin, H., Infantino, G., Masarone, M., Pugliese, N., Tulone, A., Di Marco, V., Cammà, C. & Petta, S. (2025). Impact of first and further decompensation in patients with compensated ACLD due to MASLD. Journal of hepatology.
- Shengir, M., Elgretli, W., Cinque, F., Ramanakumar, A. V., Lombardi, R., Cespiati, A., Fracanzani, A. L., Ballesteros, L., Deschenes, M., Wong, P., Chen, T. & Sebastiani, G. (2025). Metabolic Factors Drive Early Increase in Hepatic Steatosis Despite Improvement in Non-Invasive Fibrosis Markers after Hepatitis C Eradication with Direct-Acting Antivirals. Clinics and research in hepatology and gastroenterology, p. 102639.
- Kronfli, N., Mambro, A., O'Brien, A., Dussault, C., Chalifoux, S., Balso, L. D., Petropoulos, A., Lim, M., Halavrezos, A., Lebouche, B., Sebastiani, G., Klein, M. B. & Cox, J. (2025). A pre-post study of the impact of a multidisciplinary model of care on linkage to hepatitis C care following release from prison: The Beyond Prison Walls study. The International journal on drug policy, vol. 143, p. 104873.
- Lee, T.-H., Wegermann, K., Sutha, K., Cholankeril, G., Chu, C.-Y., Nguyen Galvan, N. T., Rana, A., Goss, J. A., Lambing, T., Cinque, F., Sebastiani, G., Patel, K., Naggie, S. & Wolfe, C. R. (2025). Beyond the HOPE Act: Roadmap to Expanding Kidney and Liver Transplants for People with Human Immunodeficiency Virus Utilizing Grafts from Donors with Human Immunodeficiency Virus. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
- Cinque, F. & Sebastiani, G. (2025). Lifestyle first: tackling MASLD in people living with HIV. The lancet. HIV, vol. 12, p. e394-e395.
- Burnside, J., Cinque, F., Sebastiani, G., Ramji, A., Patel, K., Swain, M. & Saeed, S. (2025). Sex differences in the prevalence and cardiometabolic risk profiles of steatotic liver disease: A Canadian Longitudinal Study on Aging analysis. Canadian journal of public health = Revue canadienne de sante publique.
- Zanframundo, G., Dourado, E., Bauer-Ventura, I., Faghihi-Kashani, S., Yoshida, A., Loganathan, A., Rivero-Gallegos, D., Lim, D., Bozán, F., Sambataro, G., Bae, S. S., Yamano, Y., Bonella, F., Corte, T. J., Doyle, T. J., Fiorentino, D., Gonzalez-Gay, M. A., Hudson, M., Kuwana, M., Lundberg, I. E., Mammen, A., McHugh, N., Miller, F. W., Montecucco, C., Oddis, C. V., Rojas-Serrano, J., Schmidt, J., Selva-O'Callaghan, A., Werth, V. P., Hansen, P., Rozza, D., Scirè, C. A., Sakellariou, G., Kaneko, Y., Triantafyllias, K., Castañeda, S., Alberti, M. L., Merino, M. G. G., Fiehn, C., Molad, Y., Govoni, M., Nakashima, R., Alpsoy, E., Giannini, M., Chinoy, H., Gallay, L., Ebstein, E., Campagne, J., Saraiva, A. P., Conticini, E., Sebastiani, G. D., Nuño-Nuño, L., Scarpato, S., Schiopu, E., Parker, M., Limonta, M., CLASS project participating investigators, Cavagna, L. & Aggarwal, R. (2025). The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project. Annals of the rheumatic diseases, vol. 84, p. 1207-1220.
- Feng, G., Yilmaz, Y., Valenti, L., Seto, W.-K., Pan, C. Q., Méndez-Sánchez, N., Ye, F., Sookoian, S., Targher, G., Byrne, C. D., Chan, W.-K., Treeprasertsuk, S., Yu, H. H., Kim, S. U., George, J., Xu, W.-J., Sebastiani, G., Ocama, P., Ryan, J. D., Lupșor-Platon, M., Ghazinyan, H., Hamid, S., Perera, N., Alswat, K., Isakov, V., Pan, Q., Sarin, S. K., Schattenberg, J. M., Sotoudeheian, M., Wong, Y. J., Sharara, A. I., Al-Busafi, S. A., Opio, C. K., Chai, J., Fouad, Y., Shi, Y., Al-Mahtab, M., Zhang, S., Pirola, C. J., Wong, V.-W. & Zheng, M.-H. (2025). Global Burden of Major Chronic Liver Diseases in 2021. Liver international : official journal of the International Association for the Study of the Liver, vol. 45, p. e70058.
- Feng, G., Targher, G., Byrne, C. D., Yilmaz, Y., Wai-Sun Wong, V., Adithya Lesmana, C. R., Adams, L. A., Boursier, J., Papatheodoridis, G., El-Kassas, M., Méndez-Sánchez, N., Sookoian, S., Castera, L., Chan, W.-K., Ye, F., Treeprasertsuk, S., Cortez-Pinto, H., Yu, H. H., Kim, W., Romero-Gómez, M., Nakajima, A., Win, K. M., Kim, S. U., Holleboom, A. G., Sebastiani, G., Ocama, P., Ryan, J. D., Lupșor-Platon, M., Ghazinyan, H., Al-Mahtab, M., Hamid, S., Perera, N., Alswat, K. A., Pan, Q., Long, M. T., Isakov, V., Mi, M., Arrese, M., Sanyal, A. J., Sarin, S. K., Leite, N. C., Valenti, L., Newsome, P. N., Hagström, H., Petta, S., Yki-Järvinen, H., Schattenberg, J. M., Castellanos Fernández, M. I., Leclercq, I. A., Aghayeva, G., Elzouki, A.-N., Tumi, A., Sharara, A. I., Labidi, A., Sanai, F. M., Matar, K., Al-Mattooq, M., Akroush, M. W., Benazzouz, M., Debzi, N., Alkhatry, M., Barakat, S., Al-Busafi, S. A., Rwegasha, J., Yang, W., Adwoa, A., Opio, C. K., Sotoudeheian, M., Wong, Y. J., George, J. & Zheng, M.-H. (2025). Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021. JHEP reports : innovation in hepatology, vol. 7, p. 101271.
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