Lab Information
Giada Sebastiani (MD)
ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
Keywords
Fatty liver • serum fibrosis biomarkers • hepatitis B • hepatitis C • HIVResearch Interests
My research focuses on screening for liver disease and fatty liver of at risk populations, including HIV+ patients, patients with inflammatory bowel disease, liver transplant recipients. To conduct these studies, I employ a non-invasive machine, which is ultrasound based, named Fibroscan. Moreover, I am conducting interventional trials to reduce the fatty liver by vitamin E and switch to less hepatotoxic drugs.Team Members
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Latest Publications
- Sebastiani, G., Milic, J., Gioe, C., Al Hinai, A. S., Cervo, A., Lebouche, B., Deschenes, M., Cascio, A., Mazzola, G. & Guaraldi, G. (2022). Diagnosis of liver fibrosis in ageing patients with HIV at risk for non-alcoholic fatty liver disease in Italy and Canada: assessment of a two-tier pathway. The lancet. HIV, vol. 9 Suppl 1, p. S4.
- Pennisi, G., Pipitone, R. M., Cabibi, D., Enea, M., Romero-Gomez, M., Viganò, M., Bugianesi, E., Wong, V.-W., Fracanzani, A. L., Sebastiani, G., Berzigotti, A., Di Salvo, F., Giannone, A. G., La Mantia, C., Lupo, G., Porcasi, R., Vernuccio, F., Zito, R., Di Marco, V., Cammà, C., Craxì, A., de Ledinghen, V., Grimaudo, S. & Petta, S. (2022). A cholestatic pattern predicts major liver-related outcomes in patients with nonalcoholic fatty liver disease. Liver international : official journal of the International Association for the Study of the Liver, vol. 42, p. 1037-1048.
- Sarvestany, S. S., Kwong, J. C., Azhie, A., Dong, V., Cerocchi, O., Ali, A. F., Karnam, R. S., Kuriry, H., Shengir, M., Candido, E., Duchen, R., Sebastiani, G., Patel, K., Goldenberg, A. & Bhat, M. (2022). Development and validation of an ensemble machine learning framework for detection of all-cause advanced hepatic fibrosis: a retrospective cohort study. The Lancet. Digital health, vol. 4, p. e188-e199.
- Sebastiani, G., Milic, J., Cervo, A., Saeed, S., Krahn, T., Kablawi, D., Al Hinai, A. S., Lebouché, B., Wong, P., Deschenes, M., Gioè, C., Cascio, A., Mazzola, G. & Guaraldi, G. (2022). Two-Tier Care Pathways for Liver Fibrosis Associated to Non-Alcoholic Fatty Liver Disease in HIV Mono-Infected Patients. Journal of personalized medicine, vol. 12.
- Cervo, A., Sebastiani, G., Milic, J., Krahn, T., Mazzola, S., Petta, S., Cascio, A., Guaraldi, G. & Mazzola, G. (2022). "Dangerous liaisons: NAFLD and liver fibrosis increase cardiovascular risk in HIV". HIV medicine.
- Milic, J., Barbieri, S., Gozzi, L., Brigo, A., Beghé, B., Verduri, A., Bacca, E., Iadisernia, V., Cuomo, G., Dolci, G., Yaacoub, D., Aprile, E., Belli, M., Venuta, M., Meschiari, M., Sebastiani, G., Clini, E., Mussini, C., Lonardo, A., Guaraldi, G. & Raggi, P. (2022). Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome. Open forum infectious diseases, vol. 9, p. ofac003.
- Destrempes, F., Gesnik, M., Chayer, B., Roy-Cardinal, M.-H., Olivié, D., Giard, J.-M., Sebastiani, G., Nguyen, B. N., Cloutier, G. & Tang, A. (2022). Quantitative ultrasound, elastography, and machine learning for assessment of steatosis, inflammation, and fibrosis in chronic liver disease. PloS one, vol. 17, p. e0262291.
- Alhinai, A., Qayyum-Khan, A., Zhang, X., Samaha, P., Metrakos, P., Deschenes, M., Wong, P., Ghali, P., Chen, T.-Y. & Sebastiani, G. (2021). Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography: A prospective study. World journal of hepatology, vol. 13, p. 2179-2191.
- Pennisi, G., Enea, M., Romero-Gomez, M., Viganò, M., Bugianesi, E., Wong, V.-W., Fracanzani, A. L., Sebastiani, G., Boursier, J., Berzigotti, A., Eslam, M., Ampuero, J., Benmassaoud, A., La Mantia, C., Mendoza, Y. P., George, J., Craxì, A., Camma', C., de Ledinghen, V. & Petta, S. (2022). Liver-related and extrahepatic events in patients with non-alcoholic fatty liver disease: a retrospective competing risks analysis. Alimentary pharmacology & therapeutics, vol. 55, p. 604-615.
- Guaraldi, G., Milic, J., Sebastiani, G. & Raggi, P. (2021). Sarcopenic obesity at the crossroad of pathogenesis of cardiometabolic diseases. Atherosclerosis, vol. 335, p. 84-86.
See also
