Lab Information

Giada Sebastiani (MD)

Scientist
Centre for Outcomes Research and Evaluation
Department of Medicine (McGill)

Research Profile

 Fundamental: 20%
 Clinical: 50%
 Epidemiology: 30%
 Evaluation: 0%
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Keywords

Fatty liver • serum fibrosis biomarkers • hepatitis B • hepatitis C • HIV

Research Interests

My research focuses on screening for liver disease and fatty liver of at risk populations, including HIV+ patients, patients with inflammatory bowel disease, liver transplant recipients. To conduct these studies, I employ a non-invasive machine, which is ultrasound based, named Fibroscan. Moreover, I am conducting interventional trials to reduce the fatty liver by vitamin E and switch to less hepatotoxic drugs.


Team Members

Name Position

Latest Publications

  1. Sebastiani, G., Milic, J., Gioe, C., Al Hinai, A. S., Cervo, A., Lebouche, B., Deschenes, M., Cascio, A., Mazzola, G. & Guaraldi, G. (2022). Diagnosis of liver fibrosis in ageing patients with HIV at risk for non-alcoholic fatty liver disease in Italy and Canada: assessment of a two-tier pathway. The lancet. HIV, vol. 9 Suppl 1, p. S4.
  2. Pennisi, G., Pipitone, R. M., Cabibi, D., Enea, M., Romero-Gomez, M., Viganò, M., Bugianesi, E., Wong, V.-W., Fracanzani, A. L., Sebastiani, G., Berzigotti, A., Di Salvo, F., Giannone, A. G., La Mantia, C., Lupo, G., Porcasi, R., Vernuccio, F., Zito, R., Di Marco, V., Cammà, C., Craxì, A., de Ledinghen, V., Grimaudo, S. & Petta, S. (2022). A cholestatic pattern predicts major liver-related outcomes in patients with nonalcoholic fatty liver disease. Liver international : official journal of the International Association for the Study of the Liver, vol. 42, p. 1037-1048.
  3. Sarvestany, S. S., Kwong, J. C., Azhie, A., Dong, V., Cerocchi, O., Ali, A. F., Karnam, R. S., Kuriry, H., Shengir, M., Candido, E., Duchen, R., Sebastiani, G., Patel, K., Goldenberg, A. & Bhat, M. (2022). Development and validation of an ensemble machine learning framework for detection of all-cause advanced hepatic fibrosis: a retrospective cohort study. The Lancet. Digital health, vol. 4, p. e188-e199.
  4. Sebastiani, G., Milic, J., Cervo, A., Saeed, S., Krahn, T., Kablawi, D., Al Hinai, A. S., Lebouché, B., Wong, P., Deschenes, M., Gioè, C., Cascio, A., Mazzola, G. & Guaraldi, G. (2022). Two-Tier Care Pathways for Liver Fibrosis Associated to Non-Alcoholic Fatty Liver Disease in HIV Mono-Infected Patients. Journal of personalized medicine, vol. 12.
  5. Cervo, A., Sebastiani, G., Milic, J., Krahn, T., Mazzola, S., Petta, S., Cascio, A., Guaraldi, G. & Mazzola, G. (2022). "Dangerous liaisons: NAFLD and liver fibrosis increase cardiovascular risk in HIV". HIV medicine.
  6. Milic, J., Barbieri, S., Gozzi, L., Brigo, A., Beghé, B., Verduri, A., Bacca, E., Iadisernia, V., Cuomo, G., Dolci, G., Yaacoub, D., Aprile, E., Belli, M., Venuta, M., Meschiari, M., Sebastiani, G., Clini, E., Mussini, C., Lonardo, A., Guaraldi, G. & Raggi, P. (2022). Metabolic-Associated Fatty Liver Disease Is Highly Prevalent in the Postacute COVID Syndrome. Open forum infectious diseases, vol. 9, p. ofac003.
  7. Destrempes, F., Gesnik, M., Chayer, B., Roy-Cardinal, M.-H., Olivié, D., Giard, J.-M., Sebastiani, G., Nguyen, B. N., Cloutier, G. & Tang, A. (2022). Quantitative ultrasound, elastography, and machine learning for assessment of steatosis, inflammation, and fibrosis in chronic liver disease. PloS one, vol. 17, p. e0262291.
  8. Alhinai, A., Qayyum-Khan, A., Zhang, X., Samaha, P., Metrakos, P., Deschenes, M., Wong, P., Ghali, P., Chen, T.-Y. & Sebastiani, G. (2021). Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography: A prospective study. World journal of hepatology, vol. 13, p. 2179-2191.
  9. Pennisi, G., Enea, M., Romero-Gomez, M., Viganò, M., Bugianesi, E., Wong, V.-W., Fracanzani, A. L., Sebastiani, G., Boursier, J., Berzigotti, A., Eslam, M., Ampuero, J., Benmassaoud, A., La Mantia, C., Mendoza, Y. P., George, J., Craxì, A., Camma', C., de Ledinghen, V. & Petta, S. (2022). Liver-related and extrahepatic events in patients with non-alcoholic fatty liver disease: a retrospective competing risks analysis. Alimentary pharmacology & therapeutics, vol. 55, p. 604-615.
  10. Guaraldi, G., Milic, J., Sebastiani, G. & Raggi, P. (2021). Sarcopenic obesity at the crossroad of pathogenesis of cardiometabolic diseases. Atherosclerosis, vol. 335, p. 84-86.
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