Lab Information
Giada Sebastiani (MD)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
Keywords
Fatty liver • serum liver biomarkers • elastography • HIV • hepatitis C • hepatitis BResearch Interests
My research focuses on screening for liver fibrosis and fatty liver of at-risk populations, including HIV+ patients, patients with diabetes and obesity, women with polycystic ovary syndrome, and patients with inflammatory bowel syndrome. To conduct these studies, I employ serum fibrosis biomarkers and a non-invasive machine, which is ultrasound-based, named Fibroscan. I am also site investigator of multiple global clinical trials for antifibrotic compounds in NASH.Team Members
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Latest Publications
- Feng, G., Targher, G., Byrne, C. D., Yilmaz, Y., Wai-Sun Wong, V., Adithya Lesmana, C. R., Adams, L. A., Boursier, J., Papatheodoridis, G., El-Kassas, M., Méndez-Sánchez, N., Sookoian, S., Castera, L., Chan, W.-K., Ye, F., Treeprasertsuk, S., Cortez-Pinto, H., Yu, H. H., Kim, W., Romero-Gómez, M., Nakajima, A., Win, K. M., Kim, S. U., Holleboom, A. G., Sebastiani, G., Ocama, P., Ryan, J. D., Lupșor-Platon, M., Ghazinyan, H., Al-Mahtab, M., Hamid, S., Perera, N., Alswat, K. A., Pan, Q., Long, M. T., Isakov, V., Mi, M., Arrese, M., Sanyal, A. J., Sarin, S. K., Leite, N. C., Valenti, L., Newsome, P. N., Hagström, H., Petta, S., Yki-Järvinen, H., Schattenberg, J. M., Castellanos Fernández, M. I., Leclercq, I. A., Aghayeva, G., Elzouki, A.-N., Tumi, A., Sharara, A. I., Labidi, A., Sanai, F. M., Matar, K., Al-Mattooq, M., Akroush, M. W., Benazzouz, M., Debzi, N., Alkhatry, M., Barakat, S., Al-Busafi, S. A., Rwegasha, J., Yang, W., Adwoa, A., Opio, C. K., Sotoudeheian, M., Wong, Y. J., George, J. & Zheng, M.-H. (2025). Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021. JHEP reports : innovation in hepatology, vol. 7, p. 101271.
- Elgretli, W., Shengir, M., Sasson, S., Ramanakumar, A. V., Cinque, F., Ballestreros, L. E. R., Deschenes, M., Wong, P., Chen, T., Kronfli, N., Saeed, S., Keeshan, A., Tandon, S., Cooper, C. & Sebastiani, G. (2025). Association of MASLD Phenotypes With Liver Fibrosis in Hepatitis C: The Role of Cardiometabolic Risk Factors. Journal of viral hepatitis, vol. 32, p. e70004.
- Righetti, R., Cinque, F., Patel, K. & Sebastiani, G. (2025). The role of noninvasive biomarkers for monitoring cell injury in advanced liver fibrosis. Expert review of gastroenterology & hepatology, p. 1-16.
- Pradhan, R., Yin, H., Lu, S., Sebastiani, G., Yu, O., Suissa, S. & Azoulay, L. (2025). Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors and the Prevention of Cirrhosis Among Patients With Type 2 Diabetes. Diabetes care, vol. 48, p. 444-454.
- Wu, C., Targher, G., Byrne, C. D., Mao, Y., Cheung, T. T., Yilmaz, Y., Valenti, L., Méndez-Sánchez, N., Sookoian, S., Chan, W.-K., Treeprasertsuk, S., Yu, H. H., Kim, S. U., George, J., Hu, D., Sebastiani, G., Ryan, J. D., Oviedo, R. J., Zhong, J.-H., Schattenberg, J. M., Lonardo, A., Ruiz-Úcar, E., Seto, W.-K., Sotoudeheian, M., Ocama, P., Lupșor-Platon, M., Yang, T., Ghazinyan, H., Pan, Q., Hamid, S., Adams, L., Chai, J., Prasad, A., Perera, N., Alswat, K., Isakov, V., Sarin, S. K., Sharara, A. I., Sanai, F. M., Al-Busafi, S. A., Opio, C. K., Toro-Huamanchumo, C. J., Yang, W., Wong, Y. J., Torzilli, G., Fouad, Y. & Zheng, M.-H. (2025). Global, regional, and national burden of primary liver cancer attributable to metabolic risks: an analysis of the Global Burden of Disease Study 1990-2021. The American journal of gastroenterology.
- Romano, J., Burnside, J., Sebastiani, G., Ramji, A., Patel, K., Swain, M. & Saeed, S. (2024). Examining the prevalence of hepatic steatosis and advanced fibrosis using non-invasive measures across Canada: A national estimate using the Canadian Health Measures Survey (CHMS) from 2009-2019. Annals of hepatology, p. 101757.
- Kronfli, N., Mambro, A., Riback, L. R., Ortiz-Paredes, D., Dussault, C., Chalifoux, S., Del Balso, L., Petropoulos, A., Lim, M., Halavrezos, A., Sebastiani, G., Klein, M. B., Lebouche, B., Cox, J. & Akiyama, M. J. (2024). Perceived patient navigator services and characteristics to address barriers to linkage to hepatitis C care among people released from provincial prison in Quebec, Canada. The International journal on drug policy, vol. 133, p. 104624.
- Truscello, E., Wang, S., Young, J., Sebastiani, G., Walmsley, S. L., Hull, M., Cooper, C. & Klein, M. B. (2025). Changes in hepatic steatosis before and after direct acting antiviral treatment in people living with HIV and Hepatitis C coinfection. The Journal of infectious diseases, vol. 231, p. e101-e112.
- Zeng, X.-F., Varady, K. A., Wang, X.-D., Targher, G., Byrne, C. D., Tayyem, R., Latella, G., Bergheim, I., Valenzuela, R., George, J., Newberry, C., Zheng, J.-S., George, E. S., Spearman, C. W., Kontogianni, M. D., Ristic-Medic, D., Peres, W. A. F., Depboylu, G. Y., Yang, W., Chen, X., Rosqvist, F., Mantzoros, C. S., Valenti, L., Yki-Järvinen, H., Mosca, A., Sookoian, S., Misra, A., Yilmaz, Y., Kim, W., Fouad, Y., Sebastiani, G., Wong, V.-W., Åberg, F., Wong, Y. J., Zhang, P., Bermúdez-Silva, F.-J., Ni, Y., Lupsor-Platon, M., Chan, W. K., Méndez-Sánchez, N., de Knegt, R. J., Alam, S., Treeprasertsuk, S., Wang, L., Du, M., Zhang, T., Yu, M.-L., Zhang, H., Qi, X., Liu, X., Pinyopornpanish, K., Fan, Y.-C., Kaijun, N., Jimenez-Chillaron, J. C. & Zheng, M.-H. (2024). The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: an international multidisciplinary expert consensus. Metabolism: clinical and experimental, p. 156028.
- Volniansky, A., Lefebvre, T. L., Kulbay, M., Fan, B., Aslan, E., Vu, K.-N., Montagnon, E., Nguyen, B. N., Sebastiani, G., Giard, J.-M., Sylvestre, M.-P., Gilbert, G., Cloutier, G. & Tang, A. (2024). Inter-visit and inter-reader reproducibility of multi-parametric diffusion-weighted MR imaging in longitudinally imaged patients with metabolic dysfunction-associated fatty liver disease and healthy volunteers. Magnetic resonance imaging, vol. 113, p. 110223.
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