Lab Information
Giada Sebastiani (MD)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
Keywords
Fatty liver • serum liver biomarkers • elastography • HIV • hepatitis C • hepatitis BResearch Interests
My research focuses on screening for liver fibrosis and fatty liver of at-risk populations, including HIV+ patients, patients with diabetes and obesity, women with polycystic ovary syndrome, and patients with inflammatory bowel syndrome. To conduct these studies, I employ serum fibrosis biomarkers and a non-invasive machine, which is ultrasound-based, named Fibroscan. I am also site investigator of multiple global clinical trials for antifibrotic compounds in NASH.Team Members
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Latest Publications
- Farhat, R., Zamora-Medina, M. D. C., Bae, S.-C., Barber, M. R. W., Clarke, A. E., Fortin, P. R., Touma, Z., Laskin, C. A., Malhamé, I., Sebastiani, G., Peschken, C., Ugarte-Gil, M. F., Legge, A., Bernatsky, S. & Vinet, É. (2026). Increased Risk of Intrahepatic Cholestasis of Pregnancy in Women With Systemic Lupus Erythematosus Exposed to Azathioprine. Arthritis & rheumatology (Hoboken, N.J.).
- Cinque, F., Saeed, S., Farina, F., Kablawi, D., Lim, J., Cascio, A., Gioè, C., Tsochatzis, E., Lombardi, R., Cordie, A., Mohamed, R., Kamel, A. M., Esmat, G., Bandera, A., Milic, J., Benke, D., Elamouri, F., Rockstroh, J. K., Guaraldi, G. & Sebastiani, G. (2026). FIB-4 fails to identify significant liver fibrosis in people with HIV: A large multinational screening study. Hepatology (Baltimore, Md.).
- Burnside, J., Djerboua, M., Flemming, J. A., Sebastiani, G., Wong, W. W. L., Lu, Z., Bajaj, H. S., Patel, K., Biondi, M., Betel, M., Nahwegahbow, A., Greenwald, Z. R., Moodie, E. E. M. & Saeed, S. (2026). Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis. Scientific reports.
- Yoon, S. Y., El Bouzaidi Tiali, S., Wing, S., Davalan, W., Jatana, S., Slapcoff, L., Nitulescu, R., Rahme, E., Nakhla, M., Morin, S. N., Sebastiani, G. & Sapir-Pichhadze, R. (2026). Metabolic Dysfunction-Associated Steatotic Liver Disease and Kidney Transplant Outcomes. Kidney international reports, vol. 11, p. 106477.
- Zhou, X.-D., Sebastiani, G. & Zheng, M.-H. (2026). Reply to: "Hypertension and long-term adverse clinical outcomes in MASLD: Sensitivity analyses for unmeasured or uncontrolled confounding". Journal of hepatology.
- Hagström, H., Hellmund, C., Lazarus, J. V., Ota, R., Rinella, M. E., Sebastiani, G., Tefos, F., Younossi, Z. M. & Noureddin, M. (2026). Clinical Outcomes and Non-Invasive Testing in Metabolic Dysfunction-Associated Steatohepatitis With Cirrhosis: A Systematic Review. Liver international : official journal of the International Association for the Study of the Liver, vol. 46, p. e70608.
- Marquardt, J., Ota, R., Sebastiani, G., Baca, D. M., Smith, E., Wallinger, H., Tebbs, K., Quinones, E., Amari, L. & Bugianesi, E. (2026). Real-world quality of life and healthcare resource utilization in patients with metabolic dysfunction-associated steatohepatitis. JHEP reports : innovation in hepatology, vol. 8, p. 101766.
- Shaheen, A.-A., Baguley, E., Swain, M. G., Tam, M., Ma, M. M., Sebastiani, G., Jiang, J., Lee, F., Medellin, A. & Abraldes, J. G. (2026). Diabetes and obesity reduce FIB-4 accuracy in MASLD referral pathways. JHEP reports : innovation in hepatology, vol. 8, p. 101735.
- Wu, C.-T., Targher, G., Byrne, C. D., Younossi, Z. M., Armstrong, M. J., Luu, H. N., Lesmana, C. R. A., Rustgi, V. K., Thomas, J. A., Okabayashi, K., Lee, J. W. J., El-Serag, H. B., Kim, W., Zhang, H.-J., Lonardo, A., Souza, M., George, E. S., Yang, W., Yilmaz, Y., Papatheodoridis, G., Sookoian, S., Romero-Gómez, M., Sebastiani, G., Schattenberg, J. M., El-Kassas, M., Chan, W.-K., Ocama, P., Lupșor-Platon, M., Perera, N., Alswat, K., Méndez-Sánchez, N., Wong, V.-W., Chai, J., Tilg, H., Sung, J.-J. & Zheng, M.-H. (2026). Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement. Gut.
- Dinh, D. A., Betel, M., Swain, M., Lazarus, J. V., Joshi, S., Cusi, K., Kim, J. W., Jung, H.-M., Dale, C., Burnside, J., Sebastiani, G. & Saeed, S. (2025). Barriers and facilitators to liver fibrosis screening: Perspectives and practices of Canadian primary care physicians. Canadian liver journal, vol. 8, p. 554-566.
See also
