Lab Information
Marina Klein (MD/MSc)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
http://www.cocostudy.ca/
Keywords
HIV • Hepatitis C • clinical trials • epidemiology • antiretrovirals • prospective cohortResearch Interests
My research program builds on years of multidisciplinary work leading one of the largest cohorts focused on HIV and hepatitis C virus (HCV) co-infection in the world. As Canada Research Chair in Clinical and Epidemiologic Studies of Chronic Viral Infections in Vulnerable Populations, I am documenting the impact of new HCV therapies on health outcomes, designing and testing tailored approaches to increase access to diagnosis and treatment, building capacity for research with Indigenous communities, and using evidence generated to advocate for policy change. My goal is to pave the way to eliminating HCV and other chronic viral infections in Canada and globally. To this end, I am leading an ambitious project called Montreal Sans Hep C, which aims to make Montreal the first City in North America to eliminate HCV.Team Members
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Latest Publications
- Long, C., Cinque, F., Kablawi, D., Kim, D. H. D., Tadjo, T. F., Elgretli, W., Ballesteros, L. R., Lupu, A., Nudo, M., Lebouché, B., Kronfli, N., Cox, J., Costiniuk, C. T., De Pokomandy, A., Routy, J.-P., Klein, M. B., Lamonde, F., Agnihotram, R. V., Saeed, S. & Sebastiani, G. (2024). Material deprivation is associated with liver stiffness and liver-related outcomes in people with HIV. Liver international : official journal of the International Association for the Study of the Liver.
- Bianco, O. E., Abdi, A., Klein, M. S., Wei, X., Sim, C. & Meuti, M. E. (2024). Consuming royal jelly alters several phenotypes associated with overwintering dormancy in mosquitoes. Frontiers in insect science, vol. 4, p. 1358619.
- Arora, A. K., Vicente, S., Engler, K., Lessard, D., Huerta, E., Ishak, J., Kronfli, N., Routy, J.-P., Cox, J., Lemire, B., Klein, M., de Pokomandy, A., Del Balso, L., Sebastiani, G., Vedel, I., Quesnel-Vallée, A., Lebouché, B. & ASAP Migrant Advisory Committee (2024). Patient-reported outcomes and experiences of migrants enrolled in a multidisciplinary HIV clinic with rapid, free, and onsite treatment dispensation: the 'ASAP' study. AIDS research and therapy, vol. 21, p. 40.
- Saeed, S., Thomas, T., Dinh, D. A., Moodie, E., Cox, J., Cooper, C., Gill, J., Martel-Laferriere, V., Panagiotoglou, D., Walmsley, S., Wong, A. & Klein, M. B. (2024). Frequent Disengagement and Subsequent Mortality Among People With HIV and Hepatitis C in Canada: A Prospective Cohort Study. Open forum infectious diseases, vol. 11, p. ofae239.
- Zhabokritsky, A., Klein, M., Loutfy, M., Guaraldi, G., Andany, N., Guillemi, S., Falutz, J., Arbess, G., Tan, D. H. S. & Walmsley, S. (2024). Non-AIDS-defining comorbidities impact health related quality of life among older adults living with HIV. Frontiers in medicine, vol. 11, p. 1380731.
- Passos-Castilho, A. M., Murphy, D. G., Blouin, K., Benedetti, A., Panagiotoglou, D., Bruneau, J., Klein, M. B., Kwong, J. C., Sander, B., Janjua, N. Z. & Greenaway, C. (2024). Ongoing Gaps in the Hepatitis C Care Cascade during the Direct-Acting Antiviral Era in a Large Retrospective Cohort in Canada: A Population-Based Study. Viruses, vol. 16.
- Sacks-Davis, R., van Santen, D. K., Boyd, A., Young, J., Stewart, A., Doyle, J. S., Rauch, A., Mugglin, C., Klein, M., van der Valk, M., Smit, C., Jarrin, I., Berenguer, J., Lacombe, K., Requena, M.-B., Wittkop, L., Leleux, O., Bonnet, F., Salmon, D., Matthews, G. V., Guy, R., Martin, N. K., Spelman, T., Prins, M., Stoove, M., Hellard, M. & InCHEHC Collaboration (2024). Changes in incidence of hepatitis C virus reinfection and access to direct-acting antiviral therapies in people with HIV from six countries, 2010-19: an analysis of data from a consortium of prospective cohort studies. The lancet. HIV, vol. 11, p. e106-e116.
- Arora, A. K., Vicente, S., Engler, K., Lessard, D., Huerta, E., Ishak, J., Routy, J.-P., Klein, M., Kronfli, N., Cox, J., Lemire, B., de Pokomandy, A., Del Balso, L., Sebastiani, G., Vedel, I., Quesnel-Vallée, A., ASAP Migrant Advisory Committee & Lebouché, B. (2024). Impact of social determinants of health on time to antiretroviral therapy initiation and HIV viral undetectability for migrants enrolled in a multidisciplinary HIV clinic with rapid, free, and onsite B/F/TAF: 'The ASAP study'. HIV medicine, vol. 25, p. 600-607.
- Requena, M.-B., Protopopescu, C., Stewart, A. C., van Santen, D. K., Klein, M. B., Jarrin, I., Berenguer, J., Wittkop, L., Salmon, D., Rauch, A., Prins, M., van der Valk, M., Sacks-Davis, R., Hellard, M. E., Carrieri, P., Lacombe, K. & InCHEHC Collaboration (2024). All-cause mortality before and after DAA availability among people living with HIV and HCV: An international comparison between 2010 and 2019. The International journal on drug policy, vol. 124, p. 104311.
- van Santen, D. K., Stewart, A., Doyle, J. S., Stoové, M. A., Asselin, J., Klein, M. B., Young, J., Berenguer, J., Jarrin, I., Lacombe, K., Wittkop, L., Leleux, O., Salmon, D., Bonnet, F., Rauch, A., Mugglin, C., Matthews, G., Prins, M., Smit, C., Boyd, A., van der Valk, M., Sacks-Davis, R., Hellard, M. E. & InCHEHC Study Group (2024). Cohort Profile: International Collaboration on Hepatitis C Elimination in HIV Cohorts (InCHEHC). International journal of epidemiology, vol. 53.
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