Lab Information

Marina Klein (MD/MSc)

Senior Scientist
Centre for Outcomes Research and Evaluation
Department of Medicine (McGill)

Research Profile

 Fundamental: 0%
 Clinical: 20%
 Epidemiology: 80%
 Evaluation: 0%
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HIV • Hepatitis C • clinical trials • epidemiology • antiretrovirals • prospective cohort

Research Interests

My research focuses on the treatment of patients with HIV and chronic hepatitis. As a prominent researcher in clinical and epidemiologic aspects of HIV and Hepatitis C co-infection, I lead one the largest multicenter cohorts focused on HIV/HCV co-infection in the world, recruiting more than one thousand HIV/HCV co-infected patients across Canada. The primary objectives of the CIHR funded cohort are to study the interactions between these two chronic viruses and their natural history in the era of combination antiretroviral therapy (cART) and to evaluate therapeutic strategies aimed at improving health outcomes in co-infected persons. We are also focused on understanding the roles of co-morbidities in the natural history of HIV/HCV co-infection. In addition, I am involved in a number of observational epidemiologic research collaborations (NA-ACCORD and CANOC) that focus on understanding long term clinical and treatment outcomes in HIV infection. My other research interests include antiretroviral pharmacoepidemiology and HIV infection in women.

Team Members

Name Position

Latest Publications

  1. Zhabokritsky, A., Klein, M., Loutfy, M., Guaraldi, G., Andany, N., Guillemi, S., Falutz, J., Arbess, G., Tan, D. H. S. & Walmsley, S. (2024). Non-AIDS-defining comorbidities impact health related quality of life among older adults living with HIV. Frontiers in medicine, vol. 11, p. 1380731.
  2. Passos-Castilho, A. M., Murphy, D. G., Blouin, K., Benedetti, A., Panagiotoglou, D., Bruneau, J., Klein, M. B., Kwong, J. C., Sander, B., Janjua, N. Z. & Greenaway, C. (2024). Ongoing Gaps in the Hepatitis C Care Cascade during the Direct-Acting Antiviral Era in a Large Retrospective Cohort in Canada: A Population-Based Study. Viruses, vol. 16.
  3. Sacks-Davis, R., van Santen, D. K., Boyd, A., Young, J., Stewart, A., Doyle, J. S., Rauch, A., Mugglin, C., Klein, M., van der Valk, M., Smit, C., Jarrin, I., Berenguer, J., Lacombe, K., Requena, M.-B., Wittkop, L., Leleux, O., Bonnet, F., Salmon, D., Matthews, G. V., Guy, R., Martin, N. K., Spelman, T., Prins, M., Stoove, M., Hellard, M. & InCHEHC Collaboration (2024). Changes in incidence of hepatitis C virus reinfection and access to direct-acting antiviral therapies in people with HIV from six countries, 2010-19: an analysis of data from a consortium of prospective cohort studies. The lancet. HIV, vol. 11, p. e106-e116.
  4. Arora, A. K., Vicente, S., Engler, K., Lessard, D., Huerta, E., Ishak, J., Routy, J.-P., Klein, M., Kronfli, N., Cox, J., Lemire, B., de Pokomandy, A., Del Balso, L., Sebastiani, G., Vedel, I., Quesnel-Vallée, A., ASAP Migrant Advisory Committee & Lebouché, B. (2024). Impact of social determinants of health on time to antiretroviral therapy initiation and HIV viral undetectability for migrants enrolled in a multidisciplinary HIV clinic with rapid, free, and onsite B/F/TAF: 'The ASAP study'. HIV medicine, vol. 25, p. 600-607.
  5. Requena, M.-B., Protopopescu, C., Stewart, A. C., van Santen, D. K., Klein, M. B., Jarrin, I., Berenguer, J., Wittkop, L., Salmon, D., Rauch, A., Prins, M., van der Valk, M., Sacks-Davis, R., Hellard, M. E., Carrieri, P., Lacombe, K. & InCHEHC Collaboration (2024). All-cause mortality before and after DAA availability among people living with HIV and HCV: An international comparison between 2010 and 2019. The International journal on drug policy, vol. 124, p. 104311.
  6. van Santen, D. K., Stewart, A., Doyle, J. S., Stoové, M. A., Asselin, J., Klein, M. B., Young, J., Berenguer, J., Jarrin, I., Lacombe, K., Wittkop, L., Leleux, O., Salmon, D., Bonnet, F., Rauch, A., Mugglin, C., Matthews, G., Prins, M., Smit, C., Boyd, A., van der Valk, M., Sacks-Davis, R., Hellard, M. E. & InCHEHC Study Group (2024). Cohort Profile: International Collaboration on Hepatitis C Elimination in HIV Cohorts (InCHEHC). International journal of epidemiology, vol. 53.
  7. Gobran, S. T., Pagliuzza, A., Khedr, O., Fert, A., Chomont, N., Bruneau, J., Klein, M. B., Ancuta, P. & Shoukry, N. H. (2023). DAA-mediated HCV cure reduces HIV DNA levels in HCV/HIV coinfected people. Journal of virology, p. e0110523.
  8. Rein, S. M., Lodi, S., Logan, R. W., Touloumi, G., Antoniadou, A., Wittkop, L., Bonnet, F., van Sighem, A., van der Valk, M., Reiss, P., Klein, M. B., Young, J., Jarrin, I., d'Arminio Monforte, A., Tavelli, A., Meyer, L., Tran, L., Gill, M. J., Lang, R., Surial, B., Haas, A. D., Justice, A. C., Rentsch, C. T., Phillips, A., Sabin, C. A., Miro, J. M., Trickey, A., Ingle, S. M., Sterne, J. A. C., Hernán, M. A. & Antiretroviral Therapy Cohort Collaboration and the HIV-CAUSAL Collaboration (2023). Integrase strand-transfer inhibitor use and cardiovascular events in adults with HIV: an emulation of target trials in the HIV-CAUSAL Collaboration and the Antiretroviral Therapy Cohort Collaboration. The lancet. HIV, vol. 10, p. e723-e732.
  9. Munari, S. C., Traeger, M. W., Menon, V., Latham, N. H., Manoharan, L., Luhmann, N., Baggaley, R., MacDonald, V., Verster, A., Siegfried, N., Conway, B., Klein, M., Bruneau, J., Stoové, M. A., Hellard, M. E. & Doyle, J. S. (2023). Determining reinfection rates by hepatitis C testing interval among key populations: A systematic review and meta-analysis. Liver international : official journal of the International Association for the Study of the Liver, vol. 43, p. 2625-2644.
  10. Leclair, V., Galindo-Feria, A. S., Rothwell, S., Kryštůfková, O., Zargar, S. S., Mann, H., Diederichsen, L. P., Andersson, H., Klein, M., Tansley, S., Rönnblom, L., Lindblad-Toh, K., Syvänen, A.-C., Wahren-Herlenius, M., Sandling, J. K., Dissect Consortium and The Immunoarray Development Consortium, McHugh, N., Lamb, J. A., Vencovský, J., Chinoy, H., Holmqvist, M., Bianchi, M., Padyukov, L., Lundberg, I. E. & Diaz-Gallo, L.-M. (2023). Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies. EBioMedicine, vol. 96, p. 104804.
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