Lab Information
Marina Klein (MD/MSc)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
http://www.cocostudy.ca/
Keywords
HIV • Hepatitis C • clinical trials • epidemiology • antiretrovirals • prospective cohortResearch Interests
My research program builds on years of multidisciplinary work leading one of the largest cohorts focused on HIV and hepatitis C virus (HCV) co-infection in the world. As Canada Research Chair in Clinical and Epidemiologic Studies of Chronic Viral Infections in Vulnerable Populations, I am documenting the impact of new HCV therapies on health outcomes, designing and testing tailored approaches to increase access to diagnosis and treatment, building capacity for research with Indigenous communities, and using evidence generated to advocate for policy change. My goal is to pave the way to eliminating HCV and other chronic viral infections in Canada and globally. To this end, I am leading an ambitious project called Montreal Sans Hep C, which aims to make Montreal the first City in North America to eliminate HCV.Team Members
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Latest Publications
- Davy-Mendez, T., Napravnik, S., Hogan, B. C., Eron, J. J., Gebo, K. A., Althoff, K. N., Moore, R. D., Silverberg, M. J., Horberg, M. A., Gill, M. J., Colasanti, J. A., Nijhawan, A., Karris, M. Y., Klein, M. B., Lang, R., Lesko, C. R., Yendewa, G. A., Kirk, G. D., McGinnis, K. A., Berry, S. A. & North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International epidemiology Databases to Evaluate AIDS (IeDEA) (2025). Changes in the prevalence of non-AIDS conditions among hospitalized persons with HIV in the United States and Canada, 2008-2018. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Fontaine, G., Taylor, N., Bruneau, J., Kronfli, N., Greenaway, C., Biondi, M. J., Klein, M. B., Saeed, S., Grebely, J. & Presseau, J. (2025). The urgent need for implementation science to achieve hepatitis C elimination. The lancet. Gastroenterology & hepatology, vol. 10, p. 498-502.
- Young, J., Wang, S., Sacks-Davis, R., Stewart, A., van Santen, D. K., van der Valk, M., Doyle, J. S., Matthews, G., Berenguer, J., Wittkop, L., Lacombe, K., Rauch, A., Stoové, M., Hellard, M., Klein, M. B. & InCHEHC Collaboration (2025). Liver fibrosis regression in people living with HIV after successful treatment for hepatitis C. Journal of acquired immune deficiency syndromes (1999), vol. 99, p. 166-174.
- Chalouni, M., Van Santen, D. K., Berenguer, J., Jarrin, I., Miro, J. M., Klein, M. B., Young, J., Torgersen, J., Rentsch, C. T., Gill, M. J., Epstein, R. L., Linas, B., Zangerle, R., Surial, B., Rauch, A., Touloumi, G., Papadopoulos, A., Wittkop, L., Van Der Valk, M., Boyd, A., Monforte, A. D., Puoti, M., Logan, R. W., Rein, S. M., Hernán, M. A. & Lodi, S. (2025). Time to direct-acting antivirals initiation and liver-related events in people with HIV and Hepatitis C virus. AIDS (London, England).
- Marathe, G., Moodie, E. E., Brouillette, M.-J., Delaunay, C. L., Cox, J., Cooper, C., Martel-Laferrière, V., Hull, M., Wong, A., Walmsley, S., Klein, M. B. & Canadian Co-Infection Cohort (2024). Effect of depressive symptoms on health services utilization in the HIV and hepatitis C co-infected population in Canada. AIDS care, p. 1-7.
- Harney, B. L., Sacks-Davis, R., van Santen, D. K., Stewart, A. C., Matthews, G. V., Carson, J. M., Klein, M. B., Lacombe, K., Wittkop, L., Salmon, D., Leleux, O., Merchadou, L., van der Valk, M., Smit, C., Prins, M., Boyd, A., Berenguer, J., Jarrin, I., Rauch, A., Hellard, M. E. & Doyle, J. S. (2025). Unsuccessful Direct Acting Antiviral Hepatitis C Treatment Among People With HIV: Findings From an International Cohort. Liver international : official journal of the International Association for the Study of the Liver, vol. 45, p. 1-13.
- Ma, Y., Lessard, D., Vicente, S., Engler, K., Rodriguez Cruz, A., Laymouna, M., Opal-COVID Patient Expert Committee, Hijal, T., Del Balso, L., Thériault, G., Paisible, N., Kronfli, N., Pomey, M.-P., Peiris, H., Barkati, S., Brouillette, M.-J., Klein, M., Cox, J., de Pokomandy, A., Asselah, J., Bartlett, S. J. & Lebouché, B. (2024). Implementing a Patient Portal for the Remote Follow-Up of Self-Isolating Patients With COVID-19 Infection Through Patient and Stakeholder Engagement (the Opal-COVID Study): Mixed Methods Pilot Study. Journal of participatory medicine, vol. 16, p. e48194.
- Zhabokritsky, A., Klein, M., Harris, M., Loutfy, M., Guillemi, S., Tan, D. H. S., Falutz, J., Andany, N., Guaraldi, G., Lovblom, L. E. & Walmsley, S. (2024). Prevalence and Correlates of Frailty Among Older Adults Living With HIV in the CHANGE HIV Cohort. Journal of acquired immune deficiency syndromes (1999), vol. 97, p. 226-231.
- Kronfli, N., Mambro, A., Riback, L. R., Ortiz-Paredes, D., Dussault, C., Chalifoux, S., Del Balso, L., Petropoulos, A., Lim, M., Halavrezos, A., Sebastiani, G., Klein, M. B., Lebouche, B., Cox, J. & Akiyama, M. J. (2024). Perceived patient navigator services and characteristics to address barriers to linkage to hepatitis C care among people released from provincial prison in Quebec, Canada. The International journal on drug policy, vol. 133, p. 104624.
- Truscello, E., Wang, S., Young, J., Sebastiani, G., Walmsley, S. L., Hull, M., Cooper, C. & Klein, M. B. (2025). Changes in hepatic steatosis before and after direct acting antiviral treatment in people living with HIV and Hepatitis C coinfection. The Journal of infectious diseases, vol. 231, p. e101-e112.
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