Lab Information
Marina Klein (MD/MSc)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
http://www.cocostudy.ca/
Keywords
HIV • Hepatitis C • clinical trials • epidemiology • antiretrovirals • prospective cohortResearch Interests
My research focuses on the treatment of patients with HIV and chronic hepatitis. As a prominent researcher in clinical and epidemiologic aspects of HIV and Hepatitis C co-infection, I lead one the largest multicenter cohorts focused on HIV/HCV co-infection in the world, recruiting more than one thousand HIV/HCV co-infected patients across Canada. The primary objectives of the CIHR funded cohort are to study the interactions between these two chronic viruses and their natural history in the era of combination antiretroviral therapy (cART) and to evaluate therapeutic strategies aimed at improving health outcomes in co-infected persons. We are also focused on understanding the roles of co-morbidities in the natural history of HIV/HCV co-infection. In addition, I am involved in a number of observational epidemiologic research collaborations (NA-ACCORD and CANOC) that focus on understanding long term clinical and treatment outcomes in HIV infection. My other research interests include antiretroviral pharmacoepidemiology and HIV infection in women.Team Members
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Latest Publications
- Gobran, S. T., Pagliuzza, A., Khedr, O., Fert, A., Chomont, N., Bruneau, J., Klein, M. B., Ancuta, P. & Shoukry, N. H. (2023). DAA-mediated HCV cure reduces HIV DNA levels in HCV/HIV coinfected people. Journal of virology, p. e0110523.
- Rein, S. M., Lodi, S., Logan, R. W., Touloumi, G., Antoniadou, A., Wittkop, L., Bonnet, F., van Sighem, A., van der Valk, M., Reiss, P., Klein, M. B., Young, J., Jarrin, I., d'Arminio Monforte, A., Tavelli, A., Meyer, L., Tran, L., Gill, M. J., Lang, R., Surial, B., Haas, A. D., Justice, A. C., Rentsch, C. T., Phillips, A., Sabin, C. A., Miro, J. M., Trickey, A., Ingle, S. M., Sterne, J. A. C., Hernán, M. A. & Antiretroviral Therapy Cohort Collaboration and the HIV-CAUSAL Collaboration (2023). Integrase strand-transfer inhibitor use and cardiovascular events in adults with HIV: an emulation of target trials in the HIV-CAUSAL Collaboration and the Antiretroviral Therapy Cohort Collaboration. The lancet. HIV, vol. 10, p. e723-e732.
- Munari, S. C., Traeger, M. W., Menon, V., Latham, N. H., Manoharan, L., Luhmann, N., Baggaley, R., MacDonald, V., Verster, A., Siegfried, N., Conway, B., Klein, M., Bruneau, J., Stoové, M. A., Hellard, M. E. & Doyle, J. S. (2023). Determining reinfection rates by hepatitis C testing interval among key populations: A systematic review and meta-analysis. Liver international : official journal of the International Association for the Study of the Liver, vol. 43, p. 2625-2644.
- Leclair, V., Galindo-Feria, A. S., Rothwell, S., Kryštůfková, O., Zargar, S. S., Mann, H., Diederichsen, L. P., Andersson, H., Klein, M., Tansley, S., Rönnblom, L., Lindblad-Toh, K., Syvänen, A.-C., Wahren-Herlenius, M., Sandling, J. K., Dissect Consortium and The Immunoarray Development Consortium, McHugh, N., Lamb, J. A., Vencovský, J., Chinoy, H., Holmqvist, M., Bianchi, M., Padyukov, L., Lundberg, I. E. & Diaz-Gallo, L.-M. (2023). Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies. EBioMedicine, vol. 96, p. 104804.
- Davy-Mendez, T., Napravnik, S., Hogan, B. C., Eron, J. J., Gebo, K. A., Althoff, K. N., Moore, R. D., Silverberg, M. J., Horberg, M. A., Gill, M. J., Rebeiro, P. F., Karris, M. Y., Klein, M. B., Kitahata, M. M., Crane, H. M., Nijhawan, A., McGinnis, K. A., Thorne, J. E., Lima, V. D., Bosch, R. J., Colasanti, J. A., Rabkin, C. S., Lang, R. & Berry, S. A. (2023). Hospital Readmissions among Persons with HIV in the United States and Canada, 2005-2018: A Collaboration of Cohort Studies. The Journal of infectious diseases.
- Kim, J., Newcomb, C. W., Carbonari, D. M., Torgersen, J., Althoff, K. N., Kitahata, M. M., Klein, M. B., Moore, R. D., Reddy, K. R., Silverberg, M. J., Mayor, A. M., Horberg, M. A., Cachay, E. R., Lim, J. K., Gill, M. J., Chew, K., Sterling, T. R., Hull, M., Seaberg, E. C., Kirk, G. D., Coburn, S. B., Lang, R., McGinnis, K. A., Gebo, K. A., Napravnik, S., Kim, H. N., Lo Re, V. & North American AIDS Cohort Collaboration on Research and Design of IeDEA (2023). Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. PloS one, vol. 18, p. e0290889.
- Shengir, M., Lebouche, B., Elgretli, W., Saeed, S., Ramanakumar, A. V., Giannakis, A., De Pokomandy, A., Cox, J., Costiniuk, C., Routy, J.-P., Klein, M. B. & Sebastiani, G. (2023). Switch to a raltegravir-based antiretroviral regimen in people with HIV and non-alcoholic fatty liver disease: A randomized controlled trial. HIV medicine.
- Cinque, F., Saeed, S., Kablawi, D., Ramos Ballesteros, L., Elgretli, W., Moodie, E. E. M., Price, C., Monteith, K., Cooper, C., Walmsley, S. L., Pick, N., Murray, M. C. M., Cox, J., Kronfli, N., Costiniuk, C. T., de Pokomandy, A., Routy, J.-P., Lebouché, B., Klein, M. B. & Sebastiani, G. (2023). Role of fatty liver in the epidemic of advanced chronic liver disease among people with HIV: protocol for the Canadian LIVEHIV multicentre prospective cohort. BMJ open, vol. 13, p. e076547.
- Mboumba Bouassa, R.-S., Comeau, E., Alexandrova, Y., Pagliuzza, A., Yero, A., Samarani, S., Needham, J., Singer, J., Lee, T., Bobeuf, F., Vertzagias, C., Sebastiani, G., Margolese, S., Mandarino, E., Klein, M. B., Lebouché, B., Routy, J.-P., Chomont, N., Costiniuk, C. T. & Jenabian, M.-A. (2023). Effects of Oral Cannabinoids on Systemic Inflammation and Viral Reservoir Markers in People with HIV on Antiretroviral Therapy: Results of the CTN PT028 Pilot Clinical Trial. Cells, vol. 12.
- Snell, G., Marshall, A. D., van Gennip, J., Bonn, M., Butler-McPhee, J., Cooper, C. L., Kronfli, N., Williams, S., Bruneau, J., Feld, J. J., Janjua, N. Z., Klein, M., Cunningham, N., Grebely, J. & Bartlett, S. R. (2023). Public reimbursement policies in Canada for direct-acting antiviral treatment of hepatitis C virus infection: A descriptive study. Canadian liver journal, vol. 6, p. 190-200.
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