Lab Information
Giada Sebastiani (MD)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
Keywords
Fatty liver • serum liver biomarkers • elastography • HIV • hepatitis C • hepatitis BResearch Interests
My research focuses on screening for liver fibrosis and fatty liver of at-risk populations, including HIV+ patients, patients with diabetes and obesity, women with polycystic ovary syndrome, and patients with inflammatory bowel syndrome. To conduct these studies, I employ serum fibrosis biomarkers and a non-invasive machine, which is ultrasound-based, named Fibroscan. I am also site investigator of multiple global clinical trials for antifibrotic compounds in NASH.Team Members
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Latest Publications
- Yoshida, E. M., Bain, V. G., Coffin, C. S., Congly, S. E., Lee, S. S., Montano-Loza, A. J., Sebastiani, G. & Chandok, N. (2026). Canadian hepatology needs a strong, united Canada. Canadian liver journal, vol. 9, p. 343-344.
- Kehar, M., Ramji, A., Swain, M., Singer, A., Ivers, N., Schaufert, W., Betel, M., Dasgupta, K., Sebastiani, G. & Patel, K. (2026). Metabolic dysfunction-associated steatotic liver disease assessment and management: Clinical practice guidance from the Canadian Association for the Study of the Liver. Canadian liver journal, vol. 9, p. 345-388.
- de Avila, L., AlNaamani, K. M., Papatheodoridi, M., Petta, S., Hagström, H., Kim, S. U., Nakajima, A., Crespo, J., Castera, L., Alkhouri, N., Zheng, M.-H., Treeprasertsuk, S., , Tsochatzis, E., Trivikrama, S. K., Fan, J.-G., Roberts, S. K., Alswat, K., Wong, V.-W., Yilmaz, Y., Dunn, W., Francque, S., Cordie, A., Yu, M.-L., Ekstedt, M., Goh, G.-B., Oliveira, C. P., Pessoa, M. G., Chan, W. K., Castellanos Fernandez, M. I., Duseja, A., Arab, J. P., Papatheodoridis, G., Sebastiani, G., Villela-Nogueira, C., D'Ambrosio, R., Lampertico, P., Holleboom, A. G., Valsan, A., El-Kassas, M., Kobayashi, T., Kakizaki, S., Caussy, C., Pearlman, B., Pugliese, N., Vessby, J., Choudhary, N. S., Kawaguchi, T., Russo, F. P., Gadano, A., Diaz, L. A., Singal, A. K., Gunn, N., Mauricio, D., Arrese, M., Fracanzani, A., Lombardi, R., Aghemo, A., Alqahtani, S. A., Stepanova, M., Younossi, Z. M., Global MASLD Study Investigators on behalf of the Global NASH/MASH Council , Ananchuensook, P., Balakumaran, L. K., Lam, B., Venu, A., Pennisi, G., Shang, Y., Liu, W.-Y., Lee, H. W., Iruzubieta, P., Nadeem, R., Cinque, F., Zoncapé, M., Yang, R.-X., Song, S. J., Dunn, N., Gadi, Z., Yeh, M.-L., Teh, K.-K., Mahadeva, S., Fabian, L. G., Almohsen, A., Leite, N., Xie, C., Friend, E., Poca, M., Segrestin, B. & Racila, A. (2026). Histologic Features and Clinical Outcomes of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease. JAMA.
- Cordie, A., Mohamed, R., Sebastiani, G., El Garhy, N., Al Sehemy, L., Saweres, A., Nagy, M. S., Awad, R. A., Atef, R., Al-Sharif, A. M., Awadh, M. Y., Ramadan, D., Al-Shayeb, A., El Khateeb, E., Tamim, H. H., Hamza, R. S., El Saadany, Z., Esmat, G. & Omar, H. (2026). Prevalence of steatotic liver disease phenotypes and liver fibrosis in people with HIV in Egypt. Transactions of the Royal Society of Tropical Medicine and Hygiene.
- Milic, J., Carobbio, A., Menozzi, M., Mancini, G., Cuomo, G., Manicardi, M., Mussi, C., Mussini, C., Raggi, P., Sebastiani, G. & Guaraldi, G. (2026). Statin use is associated with improved frailty trajectories in people with HIV. The journals of gerontology. Series A, Biological sciences and medical sciences.
- Sebastiani, G., Lee, T.-H., Cordie, A., Cinque, F., Lake, J. E., Lazarus, J. V., Rockstroh, J. K. & Guaraldi, G. (2026). Metabolic dysfunction-associated steatotic liver disease in people living with HIV: a framework for integrated screening and care. The lancet. HIV, vol. 13, p. e745-e756.
- Ko, H. H., Vienneau, J., Cooper, C. L., Crotty, P., Congly, S. E., Brahmania, M., Ramji, A., Kelly, E., Crawley, A. M., Doucette, K., Meier-Stephenson, V., Ma, M., Fung, S. K., Wong, D. K., Feld, J., Faisal, N., Kaita, K., Osiowy, C., Elkhashab, M., Tam, E., Wong, A., Bailey, R., Wong, P., Sebastiani, G., Chen, T., Conway, B., Truong, D., Tsoi, K., Nudo, C., Zhu, J., Poulin, S., Shaheen, A.-A. & Coffin, C. S. (2026). Barriers to Hepatitis B Treatment: A Multicentre Cross-Sectional Registry and Survey Study by the Canadian Hepatitis B Network. Liver international : official journal of the International Association for the Study of the Liver, vol. 46, p. e70835.
- Rapino, C., Sebastiani, G., Burnside, J., Wen, C., Ramji, A., Swain, M., Patel, K. & Saeed, S. (2026). Time-Varying Impact of Steatosis and Alcohol on Mortality: A Marginal Structural Model of the Canadian Longitudinal Study on Aging. Liver international : official journal of the International Association for the Study of the Liver, vol. 46, p. e70833.
- Burnside, J., Djerboua, M., Flemming, J. A., Sebastiani, G., Wong, W. W. L., Lu, Z., Bajaj, H. S., Patel, K., Biondi, M., Betel, M., Nahwegahbow, A., Greenwald, Z. R., Moodie, E. E. M. & Saeed, S. (2026). Correction: Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis. Scientific reports, vol. 16.
- Marquardt, J., Ota, R., Sebastiani, G., Baca, D. M., Wallinger, H., Quinones, E., Amari, L. & Bugianesi, E. (2026). Reply to "Real-world quality of life and healthcare resource utilization in patients with metabolic dysfunction-associated steatohepatitis - Circular definition of CVRM comorbidities undermines the validity of core subgroup comparisons". JHEP reports : innovation in hepatology, p. 101972.
See also
