Lab Information

Giada Sebastiani (MD)

Scientist
Centre for Outcomes Research and Evaluation
Department of Medicine (McGill)

Research Profile

 Fundamental: 20%
 Clinical: 50%
 Epidemiology: 30%
 Evaluation: 0%
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Keywords

Fatty liver • serum fibrosis biomarkers • hepatitis B • hepatitis C • HIV

Research Interests

My research focuses on screening for liver disease and fatty liver of at risk populations, including HIV+ patients, patients with inflammatory bowel disease, liver transplant recipients. To conduct these studies, I employ a non-invasive machine, which is ultrasound based, named Fibroscan. Moreover, I am conducting interventional trials to reduce the fatty liver by vitamin E and switch to less hepatotoxic drugs.


Team Members

Name Position

Latest Publications

  1. Burnside, J., Thomas, T., Sebastiani, G. & Saeed, S. (2023). Geographical disparities in gastroenterologists and transient elastography across Canada. Canadian liver journal, vol. 6, p. 417-424.
  2. Zoughlami, A., Serero, J., Congly, S., Zhao, I., Zhu, J., Ramji, A., Cooper, C., Wong, P., Bailey, R., Coffin, C. S., Sebastiani, G. & Canadian HBV Network (2023). Diagnosis of esophageal varices by liver stiffness and serum biomarkers in virus-related compensated advanced chronic liver disease. Canadian liver journal, vol. 6, p. 332-346.
  3. Feng, G., Valenti, L., Wong, V.-W., Fouad, Y. M., Yilmaz, Y., Kim, W., Sebastiani, G., Younossi, Z. M., Hernandez-Gea, V. & Zheng, M.-H. (2024). Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease. Nature reviews. Gastroenterology & hepatology, vol. 21, p. 46-56.
  4. Pennisi, G., Enea, M., Romero-Gomez, M., Bugianesi, E., Wai-Sun Wong, V., Fracanzani, A. L., de Ledinghen, V., George, J., Berzigotti, A., Viganò, M., Sebastiani, G., Cannella, R., Delamarre, A., Di Maria, G., Lange, N. F., Tulone, A., Di Marco, V., Cammà, C. & Petta, S. (2024). Risk of liver-related events in metabolic dysfunction-associated steatohepatitis (MASH) patients with fibrosis: A comparative analysis of various risk stratification criteria. Hepatology (Baltimore, Md.), vol. 79, p. 912-925.
  5. Allameh, A., Niayesh-Mehr, R., Aliarab, A., Sebastiani, G. & Pantopoulos, K. (2023). Oxidative Stress in Liver Pathophysiology and Disease. Antioxidants (Basel, Switzerland), vol. 12.
  6. Pugliese, N., Wong, V.-W., Schattenberg, J. M., Romero-Gomez, M., Sebastiani, G., NAFLD Expert Chatbot Working Group & Aghemo, A. (2024). Accuracy, reliability and comprehensiveness of ChatGPT generated medical responses for patients with NAFLD. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, vol. 22, p. 886-889.e5.
  7. Milic, J., Calza, S., Cantergiani, S., Albertini, M., Gallerani, A., Menozzi, M., Barp, N., Todisco, V., Renzetti, S., Motta, F., Mussini, C., Sebastiani, G., Raggi, P. & Guaraldi, G. (2023). Sarcopenic Obesity Phenotypes in Patients With HIV: Implications for Cardiovascular Prevention and Rehabilitation. The Canadian journal of cardiology, vol. 39, p. S359-S367.
  8. Shengir, M., Lebouche, B., Elgretli, W., Saeed, S., Ramanakumar, A. V., Giannakis, A., De Pokomandy, A., Cox, J., Costiniuk, C., Routy, J.-P., Klein, M. B. & Sebastiani, G. (2024). Switch to a raltegravir-based antiretroviral regimen in people with HIV and non-alcoholic fatty liver disease: A randomized controlled trial. HIV medicine, vol. 25, p. 135-142.
  9. Cinque, F., Saeed, S., Kablawi, D., Ramos Ballesteros, L., Elgretli, W., Moodie, E. E. M., Price, C., Monteith, K., Cooper, C., Walmsley, S. L., Pick, N., Murray, M. C. M., Cox, J., Kronfli, N., Costiniuk, C. T., de Pokomandy, A., Routy, J.-P., Lebouché, B., Klein, M. B. & Sebastiani, G. (2023). Role of fatty liver in the epidemic of advanced chronic liver disease among people with HIV: protocol for the Canadian LIVEHIV multicentre prospective cohort. BMJ open, vol. 13, p. e076547.
  10. Pennisi, G., Enea, M., Viganò, M., Schepis, F., de Ledinghen, V., Berzigotti, A., Wai-Sun Wong, V., Fracanzani, A. L., Sebastiani, G., Lara-Romero, C., Bugianesi, E., Svegliati-Baroni, G., Marra, F., Aghemo, A., Valenti, L., Calvaruso, V., Colecchia, A., Di Maria, G., La Mantia, C., Lin, H., Mendoza, Y. P., Pugliese, N., Ravaioli, F., Romero-Gomez, M., Saltini, D., Craxì, A., Di Marco, V., Cammà, C. & Petta, S. (2023). Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease. JHEP reports : innovation in hepatology, vol. 5, p. 100809.
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Bertrand
Lebouché


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Marina
Klein


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Philip
Wong


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Joseph
Cox


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Nadine
Kronfli


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Jean-Pierre
Routy


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