Lab Information

Cecilia Costiniuk (MD/MSc)

Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 40%
 Clinical: 40%
 Epidemiology: 20%
 Evaluation: 0%
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Keywords

HIV • HIV reservoirs • chronic lung disease • pulmonary inflammation • pulmonary immunity

Research Interests

My research focuses on potential factors associated with accelerated chronic lung disease in HIV infection. Despite the success of highly active antiretroviral therapy (HAART), individuals with HIV appear to be at increased risk of chronic lung disease which cannot be accounted for by smoking alone. I am interested in the role of the lungs as reservoirs of HIV infection, in addition to the effect of pulmonary inflammation on the size of the lung HIV reservoir in individuals on effective HAART. I am also interested in pulmonary immune abnormalities in the context of HIV infection.


Team Members

Name Position

Latest Publications

  1. Costiniuk, C. T. & Ahmad, A. (2022). Potential HIV/ART-mediated germline mutations causing congenital inborn errors of immunity in children born to HIV+ couples: an alarming spectre. AIDS (London, England), vol. 36, p. 2215-2216.
  2. Wang, Z., Jenabian, M.-A., Alexandrova, Y., Pagliuzza, A., Olivenstein, R., Samarani, S., Chomont, N., Kembel, S. W. & Costiniuk, C. T. (2022). Interplay between the Lung Microbiome, Pulmonary Immunity and Viral Reservoirs in People Living with HIV under Antiretroviral Therapy. Viruses, vol. 14.
  3. Wardell, J. D., Rueda, S., Fox, N., Costiniuk, C. T., Jenabian, M.-A., Margolese, S., Mandarino, E., Shuper, P., Hendershot, C. S., Cunningham, J. A., Arbess, G. & Singer, J. (2022). Disentangling Medicinal and Recreational cannabis Use Among People Living with HIV: An Ecological Momentary Assessment Study. AIDS and behavior.
  4. Chambers, C., Samji, H., Cooper, C. L., Costiniuk, C. T., Janjua, N. Z., Kroch, A. E., Arbess, G., Benoit, A. C., Buchan, S. A., Chung, H., Kendall, C. E., Kwong, J. C., Langlois, M.-A., Lee, S. M., Mbuagbaw, L., Mccullagh, J., Moineddin, R., Nambiar, D., Walmsley, S., Anis, A., Burchell, A. N. & COVAXHIV Study Team (2022). COVID-19 Vaccine Effectiveness among a Population-based Cohort of People Living with HIV. AIDS (London, England), vol. 36, p. F17-F26.
  5. Lau, V. I., Fowler, R., Pinto, R., Tremblay, A., Borgia, S., Carrier, F. M., Cheng, M. P., Conly, J., Costiniuk, C. T., Daley, P., Duan, E., Durand, M., Fontela, P. S., Farjou, G., Fralick, M., Geagea, A., Grant, J., Keynan, Y., Khwaja, K., Lee, N., Lee, T. C., Lim, R., O'Neil, C. R., Papenburg, J., Semret, M., Silverman, M., Sligl, W., Somayaji, R., Tan, D. H. S., Tsang, J. L. Y., Weatherald, J., Yansouni, C. P., Zarychanski, R., Murthy, S. & E-CATCO authors, AMMI Clinical Research Network and Canadian Critical Care Trials Group (2022). Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial. CMAJ open, vol. 10, p. E807-E817.
  6. Hachem, Y., Abdallah, S. J., Rueda, S., Wiese, J. L., Mehra, K., Rup, J., Cowan, J., Vigano, A. & Costiniuk, C. T. (2022). Healthcare practitioner perceptions on barriers impacting cannabis prescribing practices. BMC complementary medicine and therapies, vol. 22, p. 237.
  7. Mboumba Bouassa, R.-S., Sebastiani, G., Di Marzo, V., Jenabian, M.-A. & Costiniuk, C. T. (2022). Cannabinoids and Chronic Liver Diseases. International journal of molecular sciences, vol. 23.
  8. Yero, A., Shi, T., Routy, J.-P., Tremblay, C., Durand, M., Costiniuk, C. T. & Jenabian, M.-A. (2022). FoxP3+ CD8 T-cells in acute HIV infection and following early antiretroviral therapy initiation. Frontiers in immunology, vol. 13, p. 962912.
  9. Sohani, Z. N., Butler-Laporte, G., Aw, A., Belga, S., Benedetti, A., Carignan, A., Cheng, M. P., Coburn, B., Costiniuk, C. T., Ezer, N., Gregson, D., Johnson, A., Khwaja, K., Lawandi, A., Leung, V., Lother, S., MacFadden, D., McGuinty, M., Parkes, L., Qureshi, S., Roy, V., Rush, B., Schwartz, I., So, M., Somayaji, R., Tan, D., Trinh, E., Lee, T. C. & McDonald, E. G. (2022). Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison trial. BMJ open, vol. 12, p. e053039.
  10. Lessard, D., Dubé, K., Bilodeau, M., Keeler, P., Margolese, S., Rosenes, R., Sinyavskaya, L., Durand, M., Benko, E., Kovacs, C., Guerlotté, C., Tharao, W., Arnold, K., Masching, R., Taylor, D., Sousa, J., Ostrowski, M., Taylor, J., Kaytes, A., Smith, D., Gianella, S., Chomont, N., Angel, J. B., Routy, J.-P., Cohen, É. A., Lebouché, B. & Costiniuk, C. T. (2022). Willingness of Older Canadians with HIV to Participate in HIV Cure Research Near and After the End of Life: A Mixed-Method Study. AIDS research and human retroviruses, vol. 38, p. 670-682.
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