Lab Information

Cecilia Costiniuk (MD/MSc)

Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 40%
 Clinical: 40%
 Epidemiology: 20%
 Evaluation: 0%
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Keywords

HIV • HIV reservoirs • chronic lung disease • pulmonary inflammation • pulmonary immunity

Research Interests

My research focuses on potential factors associated with accelerated chronic lung disease in HIV infection. Despite the success of highly active antiretroviral therapy (HAART), individuals with HIV appear to be at increased risk of chronic lung disease which cannot be accounted for by smoking alone. I am interested in the role of the lungs as reservoirs of HIV infection, in addition to the effect of pulmonary inflammation on the size of the lung HIV reservoir in individuals on effective HAART. I am also interested in pulmonary immune abnormalities in the context of HIV infection.


Team Members

Name Position

Latest Publications

  1. Brumme, Z. L., Mwimanzi, F., Lapointe, H. R., Cheung, P. K., Sang, Y., Duncan, M. C., Yaseen, F., Agafitei, O., Ennis, S., Ng, K., Basra, S., Lim, L. Y., Kalikawe, R., Speckmaier, S., Moran-Garcia, N., Young, L., Ali, H., Ganase, B., Umviligihozo, G., Harrison Omondi, F., Atkinson, K., Sudderuddin, H., Toy, J., Sereda, P., Burns, L., Costiniuk, C. T., Cooper, C., Anis, A. H., Leung, V., Holmes, D., DeMarco, M. L., Simons, J., Hedgcock, M., Romney, M. G., Barrios, R., Guillemi, S., Brumme, C. J., Pantophlet, R., Montaner, J. S. G., Niikura, M., Harris, M., Hull, M. & Brockman, M. A. (2022). Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy. NPJ vaccines, vol. 7, p. 28.
  2. DeMarino, C., Cowen, M., Khatkar, P., Cotto, B., Branscome, H., Kim, Y., Sharif, S. A., Agbottah, E. T., Zhou, W., Costiniuk, C. T., Jenabian, M.-A., Gelber, C., Liotta, L. A., Langford, D. & Kashanchi, F. (2022). Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription. Cells, vol. 11.
  3. Almomen, A., Cox, J., Lebouche, B., Cheng, M., Frenette, C., Routy, J.-P. & Costiniuk, C. T. (2022). Ongoing impact of the social determinants of health during the second and third waves of the COVID-19 pandemic in People Living with HIV receiving care in a Montreal-based Tertiary Care Centre. AIDS research and human retroviruses, vol. 38, p. 359-362.
  4. Alexandrova, Y., Costiniuk, C. T. & Jenabian, M.-A. (2021). Pulmonary Immune Dysregulation and Viral Persistence During HIV Infection. Frontiers in immunology, vol. 12, p. 808722.
  5. Isnard, S., Fombuena, B., Ouyang, J., Royston, L., Lin, J., Bu, S., Sheehan, N., Lakatos, P. L., Bessissow, T., Chomont, N., Klein, M., Lebouché, B., Costiniuk, C. T., Routy, B., Marette, A., Routy, J.-P. & Camu Camu Study Group (2022). Camu Camu effects on microbial translocation and systemic immune activation in ART-treated people living with HIV: protocol of the single-arm non-randomised Camu Camu prebiotic pilot study (CIHR/CTN PT032). BMJ open, vol. 12, p. e053081.
  6. Costiniuk, C. T., Singer, J., Langlois, M.-A., Kulic, I., Needham, J., Burchell, A., Jenabian, M.-A., Walmsley, S., Ostrowski, M., Kovacs, C., Tan, D., Harris, M., Hull, M., Brumme, Z., Brockman, M., Margolese, S., Mandarino, E., Angel, J. B., Routy, J.-P., Anis, A. H. & Cooper, C. (2021). CTN 328: immunogenicity outcomes in people living with HIV in Canada following vaccination for COVID-19 (HIV-COV): protocol for an observational cohort study. BMJ open, vol. 11, p. e054208.
  7. Brumme, Z. L., Mwimanzi, F., Lapointe, H. R., Cheung, P., Sang, Y., Duncan, M. C., Yaseen, F., Agafitei, O., Ennis, S., Ng, K., Basra, S., Lim, L. Y., Kalikawe, R., Speckmaier, S., Moran-Garcia, N., Young, L., Ali, H., Ganase, B., Umviligihozo, G., Omondi, F. H., Atkinson, K., Sudderuddin, H., Toy, J., Sereda, P., Burns, L., Costiniuk, C. T., Cooper, C., Anis, A. H., Leung, V., Holmes, D., DeMarco, M. L., Simons, J., Hedgcock, M., Romney, M. G., Barrios, R., Guillemi, S., Brumme, C. J., Pantophlet, R., Montaner, J. S. G., Niikura, M., Harris, M., Hull, M. & Brockman, M. A. (2021). Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy. medRxiv : the preprint server for health sciences.
  8. Yero, A., Shi, T., Farnos, O., Routy, J.-P., Tremblay, C., Durand, M., Tsoukas, C., Costiniuk, C. T. & Jenabian, M.-A. (2021). Dynamics and epigenetic signature of regulatory T-cells following antiretroviral therapy initiation in acute HIV infection. EBioMedicine, vol. 71, p. 103570.
  9. Fehr, D., Lebouché, B., Ruppenthal, L., Brownc, M., Obasc, N., Bourbonnière, E., Girouard, J., Massicotte, A., Jenabian, M.-A., Almomen, A.-A., Frenette, C., de Pokomandy, A., Cox, J., Giannakis, A., Cheng, M., Kronfli, N., Tsoukas, C., Zahedi, N., Szabo, J., Dehghani, K., Brouillette, M.-J., Falutz, J., Turner, H., Hamel, A., Duchesneau, C., Lanthier-Brun, J., Klein, M., Routy, J.-P. & Costiniuk, C. T. (2021). Characterization of people living with HIV in a Montreal-based tertiary care center with COVID-19 during the first wave of the pandemic. AIDS care, p. 1-7.
  10. Rothan, C., Yero, A., Shi, T., Farnos, O., Chartrand-Lefebvre, C., El-Far, M., Costiniuk, C. T., Tsoukas, C., Tremblay, C., Durand, M., Jenabian, M.-A. & Canadian HIV and Aging Cohort Study (2021). Antiretroviral therapy-treated HIV-infected adults with coronary artery disease are characterized by a distinctive regulatory T-cell signature. AIDS (London, England), vol. 35, p. 1003-1014.
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Jean-Pierre
Routy


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Bertrand
Lebouché


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Marina
Klein


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Joseph
Cox


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Christos
Tsoukas


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Marie-Josée
Brouillette


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