Lab Information

Cecilia Costiniuk (MD/MSc)

Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 40%
 Clinical: 40%
 Epidemiology: 20%
 Evaluation: 0%
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Keywords

HIV • HIV reservoirs • chronic lung disease • pulmonary inflammation • pulmonary immunity • vaccine immunogenicity • endocannabinoids

Research Interests

My research focuses on factors associated with accelerated chronic lung disease in HIV infection. Despite the success of antiretroviral therapy (ART), individuals with HIV are at increased risk of chronic lung disease which cannot be accounted for by smoking alone. My lab examines the lungs as HIV reservoirs and factors within the pulmonary milieu which facilitate HIV persistence and increased chronic lung disease, despite effective ART. Similarly, I examine factors associated with vaccine immunogenicity in people with HIV in order to inform vaccination strategies. These studies are complemented by my work on the expanded endocannabinoid system as a potential target to reduce HIV reservoir sizes, inflammation and ultimately comorbidities.


Team Members

Name Position

Latest Publications

  1. Lu, J., Vulesevic, B., Burchell, A. N., Singer, J., Needham, J., Yang, Y., Qian, H., Chambers, C., Samji, H., Colmegna, I., Del Canto, S., Godin, G.-H., Habanyama, M., Hui, S. S. C., Kroch, A., Mandarino, E., Margolese, S., Martin, C., Owino, M., Lau, E., Mohammadi, T., Zhang, W., Pelaez, S., Kovacs, C., Benko, E., Cooper, C. L., Anis, A. H., Costiniuk, C. T. & COVAXHIV Study Group (2024). Sex differences in COVID-19 vaccine confidence in people living with HIV in Canada. Vaccine: X, vol. 21, p. 100566.
  2. Yero, A., Shi, T., Clain, J. A., Zghidi-Abouzid, O., Racine, G., Costiniuk, C. T., Routy, J.-P., Estaquier, J. & Jenabian, M.-A. (2024). Double-Negative T-Cells during Acute Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections and Following Early Antiretroviral Therapy Initiation. Viruses, vol. 16.
  3. Chambers, C., Cooper, C. L., Kroch, A. E., Buchan, S. A., Kendall, C. E., Kwong, J. C., Moideddin, R., Nguyen, L., Arbess, G., Benoit, A. C., Costiniuk, C. T., Habanyama, M., Janjua, N. Z., Langlois, M.-A., McCullagh, J., Mbuagbaw, L., Moqueet, N., Nambiar, D., Rueda, S., Samji, H., Tran, V., Walmsley, S., Anis, A., Burchell, A. N. & COVAXHIV Study Team (2024). Coronavirus disease 2019 outcomes in a population-based cohort of people with HIV and a matched cohort of people without HIV during Omicron variant waves. AIDS (London, England), vol. 38, p. 1597-1600.
  4. Mappin-Kasirer, B., Del Corpo, O., Gingras, M.-A., Hass, A., Hsu, J. M., Costiniuk, C. T., Ezer, N., Fraser, R. S., Lee, T. C. & McDonald, E. G. (2024). Development of a clinical risk score for the prediction of Pneumocystis jirovecii pneumonia in hospitalised patients. BMC infectious diseases, vol. 24, p. 1032.
  5. Costiniuk, C. T., Samarani, S., Wang, L., Vigano, M. & Ahmad, A. (2024). [Potential role of alveolar macrophages in HIV persistence and lung disease]. Virologie (Montrouge, France), vol. 28, p. 255-276.
  6. Costiniuk, C. T., Samarani, S., Wang, L., Vigano, M. & Ahmad, A. (2024). Potential role of alveolar macrophages in HIV persistence and lung disease. Virologie (Montrouge, France), vol. 28, p. 1-20.
  7. Yero, A., Goulet, J.-P., Shi, T., Costiniuk, C. T., Routy, J.-P., Tremblay, C., Mboumba Bouassa, R.-S., Alexandrova, Y., Pagliuzza, A., Chomont, N., Ancuta, P. & Jenabian, M.-A. (2024). Altered memory CCR6+ Th17-polarised T-cell function and biology in people with HIV under successful antiretroviral therapy and HIV elite controllers. EBioMedicine, vol. 107, p. 105274.
  8. Mboumba Bouassa, R.-S., Giorgini, G., Silvestri, C., Muller, C., Nallabelli, N., Alexandrova, Y., Durand, M., Tremblay, C., El-Far, M., Chartrand-Lefebvre, C., Messier-Peet, M., Margolese, S., Flamand, N., Costiniuk, C. T., Di Marzo, V. & Jenabian, M.-A. (2024). Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study. iScience, vol. 27, p. 110456.
  9. Mboumba Bouassa, R.-S., Needham, J., Nohynek, D., Samarani, S., Bobeuf, F., Del Balso, L., Paisible, N., Vertzagias, C., Sebastiani, G., Margolese, S., Mandarino, E., Singer, J., Klein, M., Lebouché, B., Cox, J., Vulesevic, B., Müller, A., Lau, E., Routy, J.-P., Jenabian, M.-A. & Costiniuk, C. T. (2024). Feasibility of a Randomized, Interventional Pilot Clinical Study of Oral Cannabinoids in People with HIV on Antiretroviral Therapy: CTNPT 028. Journal of personalized medicine, vol. 14.
  10. Vigano, M., Kubal, S., Lu, Y., Habib, S., Samarani, S., Cama, G., Viau, C., Farzin, H., Koudieh, N., Xia, J., Ahmad, A., Vigano, A., Costiniuk, C. T., Vigano, M., Kubal, S., Lu, Y., Habib, S., Samarani, S., Cama, G., Viau, C., Farzin, H., Koudieh, N., Xia, J., Ahmad, A., Vigano, A. & Costiniuk, C. T. (2024). Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report. Pharmaceuticals (Basel, Switzerland), vol. 17.
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