Lab Information

Cecilia Costiniuk (MD/MSc)

Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 40%
 Clinical: 40%
 Epidemiology: 20%
 Evaluation: 0%
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Keywords

HIV • HIV reservoirs • chronic lung disease • pulmonary inflammation • pulmonary immunity

Research Interests

My research focuses on potential factors associated with accelerated chronic lung disease in HIV infection. Despite the success of highly active antiretroviral therapy (HAART), individuals with HIV appear to be at increased risk of chronic lung disease which cannot be accounted for by smoking alone. I am interested in the role of the lungs as reservoirs of HIV infection, in addition to the effect of pulmonary inflammation on the size of the lung HIV reservoir in individuals on effective HAART. I am also interested in pulmonary immune abnormalities in the context of HIV infection.


Team Members

Name Position

Latest Publications

  1. Ouyang, J., Yan, J., Zhou, X., Isnard, S., Tang, S., Costiniuk, C. T., Chen, Y., Routy, J.-P. & Chen, Y. (2023). The Influence of Oral Terbinafine on Gut Fungal Microbiome Composition and Microbial Translocation in People Living with HIV Treated for Onychomycosis. Journal of fungi (Basel, Switzerland), vol. 9.
  2. Puyat, J. H., Wilton, J., Fowokan, A., Janjua, N. Z., Wong, J., Grennan, T., Chambers, C., Kroch, A., Costiniuk, C. T., Cooper, C. L., Lauscher, D., Strong, M., Burchell, A. N., Anis, A., Samji, H. & COVAXHIV Study Team (2023). COVID-19 vaccine effectiveness by HIV status and history of injection drug use: a test-negative analysis. Journal of the International AIDS Society, vol. 26, p. e26178.
  3. Ndukwe, S. O., Patel, H., Shelton, B., Concha-Garcia, S., Dullano, C., Solso, S., Hendrickx, S., Riggs, P. K., Villa, T. J., Kaytes, A., Taylor, J., Little, S. J., Lessard, D., Arora, A. K., Costiniuk, C. T., Eskaf, S., Smith, D. M., Gianella, S. & Dubé, K. (2024). People with HIV at the end of life and their next-of-kin/loved ones are willing to participate in interventional HIV cure-related research. AIDS (London, England), vol. 38, p. 235-243.
  4. Hammond, K., Lee, T., Vulesevic, B., Singer, J., Needham, J., Burchell, A. N., Samji, H., Walmsley, S., Hull, M., Jenabian, M.-A., Routy, J.-P., Margolese, S., Mandarino, E., Anis, A. H., Cooper, C. L. & Costiniuk, C. T. (2023). Preventative behaviours and COVID-19 infection in a Canadian cohort of people living with HIV. AIDS research and therapy, vol. 20, p. 73.
  5. Coelho, S. G., Rueda, S., Costiniuk, C. T., Jenabian, M.-A., Margolese, S., Mandarino, E., Shuper, P. A., Hendershot, C. S., Cunningham, J. A., Arbess, G., Singer, J. & Wardell, J. D. (2023). Knowledge of Cannabinoid Content Among People Living with HIV Who Use Cannabis: a Daily Diary Study. International journal of behavioral medicine.
  6. Dufour, C., Ruiz, M. J., Pagliuzza, A., Richard, C., Shahid, A., Fromentin, R., Ponte, R., Cattin, A., Wiche Salinas, T. R., Salahuddin, S., Sandstrom, T., Schinkel, S. B., Costiniuk, C. T., Jenabian, M.-A., Ancuta, P., Routy, J.-P., Cohen, É. A., Brumme, Z. L., Power, C., Angel, J. B. & Chomont, N. (2023). Near full-length HIV sequencing in multiple tissues collected postmortem reveals shared clonal expansions across distinct reservoirs during ART. Cell reports, vol. 42, p. 113053.
  7. Lessard, D., Lebouché, B., Morneau, A., Bilodeau, M., Rosenes, R., Sanders, J., Chomont, N., Keeler, P., Dubé, K., Margolese, S., Jenabian, M.-A., Power, C., Routy, J.-P., B Angel, J., A Cohen, E. & T Costiniuk, C. (2023). Donating One's Body to HIV Cure Research Through Canadian Medical Assistance in Dying: A Case Study. Current HIV research, vol. 21, p. 264-267.
  8. Williams, A., Khatkar, P., Branscome, H., Kim, Y., Erickson, J., Jenabian, M.-A., Costiniuk, C. T. & Kashanchi, F. (2023). The Use of CBD and Its Synthetic Analog HU308 in HIV-1-Infected Myeloid Cells. Pharmaceuticals (Basel, Switzerland), vol. 16.
  9. Cinque, F., Saeed, S., Kablawi, D., Ramos Ballesteros, L., Elgretli, W., Moodie, E. E. M., Price, C., Monteith, K., Cooper, C., Walmsley, S. L., Pick, N., Murray, M. C. M., Cox, J., Kronfli, N., Costiniuk, C. T., de Pokomandy, A., Routy, J.-P., Lebouché, B., Klein, M. B. & Sebastiani, G. (2023). Role of fatty liver in the epidemic of advanced chronic liver disease among people with HIV: protocol for the Canadian LIVEHIV multicentre prospective cohort. BMJ open, vol. 13, p. e076547.
  10. Costiniuk, C. T., Singer, J., Lee, T., Galipeau, Y., McCluskie, P. S., Arnold, C., Langlois, M.-A., Needham, J., Jenabian, M.-A., Burchell, A. N., Samji, H., Chambers, C., Walmsley, S., Ostrowski, M., Kovacs, C., Tan, D. H. S., Harris, M., Hull, M., Brumme, Z. L., Lapointe, H. R., Brockman, M. A., Margolese, S., Mandarino, E., Samarani, S., Vulesevic, B., Lebouche, B., Angel, J. B., Routy, J.-P., Cooper, C. L., Anis, A. H. & COVAXHIV Study Group (2023). Antibody neutralization capacity after COVID-19 vaccination in people with HIV (CIHR Canadian HIV trials network 328). AIDS (London, England), vol. 37, p. F25-F35.
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