Lab Information

Matthew Cheng (MD)

Junior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 40%
 Clinical: 60%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Lethal infectious diseases • opportunistic infections • sepsis • bacteremia

Research Interests

My research focuses on patients with potentially lethal infections, including those with severe manifestations of sepsis, bloodstream infections, and opportunistic infections in immunocompromised hosts. My research program aims to improve morbidity and mortality in these conditions by discovering original treatment strategies through avant-garde clinical trials. I also develop novel diagnostic assays to improve outcomes in these patients, such as using plasma cell-free DNA to monitor the host response to infection and optimize treatment decisions.


Team Members

Name Position

Latest Publications

  1. Rocheleau, G. L. Y., Lee, T., Mohammed, Y., Goodlett, D., Burns, K., Cheng, M. P., Tran, K., Sweet, D., Marshall, J., Slutsky, A. S., Murthy, S., Singer, J., Patrick, D. M., Du, B., Peng, Z., Lee, T. C., Boyd, J. H., Walley, K. R., Lamontagne, F., Fowler, R., Winston, B. W., Haljan, G., Vinh, D. C., McGeer, A., Maslove, D., Patrigeon, S. P., Mann, P., Donohoe, K., Hernandez, G., Russell, J. A. & for ARBs CORONA I Investigators (2022). Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19. Critical care medicine.
  2. Papenburg, J., Campbell, J. R., Caya, C., Dion, C., Corsini, R., Cheng, M. P., Menzies, D. & Yansouni, C. P. (2022). Adequacy of Serial Self-performed SARS-CoV-2 Rapid Antigen Detection Testing for Longitudinal Mass Screening in the Workplace. JAMA network open, vol. 5, p. e2210559.
  3. Racine, É., Boivin, G., Longtin, Y., McCormack, D., Decaluwe, H., Savard, P., Cheng, M. P., Hamelin, M.-È., Carbonneau, J., Tadount, F., Adams, K., Bourdin, B., Nantel, S., Gilca, V., Corbeil, J., De Serres, G. & Quach-Thanh, C. (2022). The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers. Influenza and other respiratory viruses.
  4. Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Tran, K. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D., Singer, J., Patrick, D. M., Marshall, J. C., Burns, K. D., Murthy, S., Mann, P. K., Hernandez, G., Donohoe, K., Rocheleau, G., Russell, J. A. & ARBs CORONA I study investigators (2022). Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort study. CMAJ open, vol. 10, p. E379-E389.
  5. Bai, A. D., Lo, C. K. L., Komorowski, A. S., Suresh, M., Guo, K., Garg, A., Tandon, P., Senecal, J., Del Corpo, O., Stefanova, I., Fogarty, C., Butler-Laporte, G., McDonald, E. G., Cheng, M. P., Morris, A. M., Loeb, M. & Lee, T. C. (2022). What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality. Open forum infectious diseases, vol. 9, p. ofac096.
  6. Bai, A. D., Lo, C. K., Komorowski, A. S., Suresh, M., Guo, K., Garg, A., Tandon, P., Senecal, J., Del Corpo, O., Stefanova, I., Fogarty, C., Butler-Laporte, G., McDonald, E. G., Cheng, M. P., Morris, A. M., Loeb, M. & Lee, T. C. (2022). Staphylococcus aureus bacteremia mortality: A systematic review and meta-analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
  7. Bai, A. D., Lo, C. K. L., Komorowski, A. S., Suresh, M., Guo, K., Garg, A., Tandon, P., Senecal, J., Del Corpo, O., Stefanova, I., Fogarty, C., Butler-Laporte, G., McDonald, E. G., Cheng, M. P., Morris, A. M., Loeb, M. & Lee, T. C. (2022). How generalizable are randomized controlled trials (RCTs) in Staphylococcus aureus bacteremia? A description of the mortality gap between RCTs and observational studies. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
  8. Almomen, A., Cox, J., Lebouche, B., Cheng, M., Frenette, C., Routy, J.-P. & Costiniuk, C. T. (2022). Ongoing impact of the social determinants of health during the second and third waves of the COVID-19 pandemic in People Living with HIV receiving care in a Montreal-based Tertiary Care Centre. AIDS research and human retroviruses, vol. 38, p. 359-362.
  9. Reyes, L. F., Murthy, S., Garcia-Gallo, E., Irvine, M., Merson, L., Martin-Loeches, I., Rello, J., Taccone, F. S., Fowler, R. A., Docherty, A. B., Kartsonaki, C., Aragao, I., Barrett, P. W., Beane, A., Burrell, A., Cheng, M. P., Christian, M. D., Cidade, J. P., Citarella, B. W., Donnelly, C. A., Fernandes, S. M., French, C., Haniffa, R., Harrison, E. M., Ho, A. Y. W., Joseph, M., Khan, I., Kho, M. E., Kildal, A. B., Kutsogiannis, D., Lamontagne, F., Lee, T. C., Bassi, G. L., Lopez Revilla, J. W., Marquis, C., Millar, J., Neto, R., Nichol, A., Parke, R., Pereira, R., Poli, S., Povoa, P., Ramanathan, K., Rewa, O., Riera, J., Shrapnel, S., Silva, M. J., Udy, A., Uyeki, T., Webb, S. A., Wils, E.-J., Rojek, A. & Olliaro, P. L. (2022). Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study. ERJ open research, vol. 8.
  10. Sharma, A., Elharram, M., Afilalo, J., Flannery, A., Afilalo, M., Tselios, C., Ni, J., Ezekowitz, J. A., Cheng, M. P., Ambrosy, A. P., Zannad, F., Brophy, J., Giannetti, N., Bessissow, A., Kronfli, N., Marelli, A., Aziz, H., Alqahtani, M., Aflaki, M., Craig, M., Lopes, R. D. & Ferreira, J. P. (2022). A Randomized Controlled Trial of Renin-Angiotensin-Aldosterone System Inhibitor Management in Patients Admitted in Hospital with COVID-19. American heart journal, vol. 247, p. 76-89.
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