Lab Information
Matthew Cheng (MD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Lethal infectious diseases • opportunistic infections • sepsis • bacteremiaResearch Interests
My research focuses on patients with potentially lethal infections, including those with severe manifestations of sepsis, bloodstream infections, and opportunistic infections in immunocompromised hosts. My research program aims to improve morbidity and mortality in these conditions by discovering original treatment strategies through avant-garde clinical trials. I also develop novel diagnostic assays to improve outcomes in these patients, such as using plasma cell-free DNA to monitor the host response to infection and optimize treatment decisions.Team Members
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Latest Publications
- Goodman, A. L., Easom, N., Bielopolski, D., Sutherland, R. K., Marks, M., Hensgens, M. P. M., Bonten, M., Bostock, J., Walls, G., Lye, D., Boyles, T., Yahav, D., Cheng, M. P., Legg, A., Paul, M., Lescure, F.-X., Lee, T. C., Tong, S. Y. C. & Davis, J. S. (2026). A review of the randomized clinical trial results from the Staphylococcus aureus network adaptive platform (SNAP) meticillin-susceptible (MSSA) and penicillin-susceptible (PSSA) domains and CloCeBa. The Journal of antimicrobial chemotherapy, vol. 81.
- Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group, Lee, T. C., Barina, L. A., Walls, G., Goodman, A. L., Yahav, D., Cheng, M. P., Bonten, M., Bowen, A. C., Boyles, T., Daneman, N., Ekkelenkamp, M. B., Ghanem-Zoubi, N., Hensgens, M. P. M., Jager, N. G. L., Kaasch, A. J., Kouijzer, I. J. E., Lewis, R. J., Lumley, T., Lye, D. C., McDonald, E. G., McKew, G., McLean, A. R. D., McMullan, B. J., McQuilten, Z. K., Morpeth, S. C., Paterson, D. L., Roberts, J. A., Robinson, J. O., Saito, H., Scarborough, M., Ten Oever, J., Turner, R. M., Tverring, J., van Hal, S. J., Webb, S. A., Whiteway, L. M., Arias, C. A., Henderson, A., Heriot, G. S., Snelling, T. L., Afra, K., Ali, S. S., Amit, S., Anagnostou, N. A., Archuleta, S., Aston, S. J., Athan, E., Baharav, N., Bai, A. D., Barber, B. E., Baskaran, A., Berkeley, M. M. A., Best, E. J., Bhilave, N. R., Bloomfield, M. G., Bond, K. A., Bostock, J., Botheras, C. L., Boyd, M. A., Bradshaw, S. M. E., Briggs, E. J., Britton, P. N., Campbell, A. J., Carr, B. Z., Chancellor, J. A., Chen, K., Cheong, E. Y., Chew, K. L., Chia, P. Y., Chomba, R., Chong, B. S. W., Clews, C. J. N., Cohen, J. M., Commons, R. J., Cutfield, T., Daley, P., Daniel, D. S., Davies, J., De, P., Denholm, J. T., Di Virgilio, M., Dishon-Benattar, Y., Dotel, R., Duan, E. H., Easom, N., Eliakim-Raz, N., England, M. M., Fahmy, M., Findlater, A. R., Flanagan, K. L., Foo, E. Z. J., Foo, H., Forster, D. P., Fralick, M., Frazer, J. L., Gador-Whyte, A. P., Garnham, K., German, G. J., Ghosh, N., Gisolf, E. H., Giulieri, S. G., Goulding, S. R., Grant, J. M., Gregson, D., Grimwade, K. C., Grupper, M., Guy, S. D., Gwee, A., Hall, V. G., Hardy, E. J., Harris, D. J., Hatcher, J., Hobbs, M. R., Holmes, N. E., Howden, B. P., Huggan, P. J., Jennings, Z. A., Johnstone, J., Juniper, T., Kalimuddin, S., Kamfose, M., Kandel, C., Kelly, M. J., Kozak, R. A., Kümin, M., Lamontagne, F., Lau, J. S. Y., Lee, I. R., Lin, R. J., Lindsay, D., Llewelyn, M. J., Longtin, Y., Lother, S. A., Luey, C. E., MacFadden, D. R., Mahony, A. A., Malden, C., Malhamé, I., Manning, L. A., Marks, M., Martin, L. J., Matthews, G. V., McGann, P. H., McMahon, J. H., Melon, A., Menon, V., Mertz, D., Meyer, M. P., Molton, J. S., Mora, J. M., Moran, E., Mortimer, L. M., Motaganahalli, S., Muller, M. P., Munro, A. P. S., Murray, F. A., Murthy, S., Nagendra, V., Nel, H., New, D. W. J., Nguyen, V., Norton, G., Norton, K. M., Nourse, C. B., Nye, C. J. S., O'Callaghan, K., O'Sullivan, M. V. N., Ong, S. W. X., Otu, A. A., Owen, M., Papenburg, J., Parkes, L. O., Paul, M., Perez-Patrigeon, S., Petersiel, N., Petrella, L., Pett, S. L., Pham, D., Piazzese, C. J., Poulin, S., Rehak, R., Rennert-May, E., Richards, A. J., Rogers, B. A., Sahng, E., Salada, B., Scheuerman, O., Schneider, K., Schulz, T. R., Schwartz, K. L., Simos, P. A., Singh, H., Sinkeler, F. S., Smith, S., Smith, B. J., Smith, S. W., Somayaji, R., Sommerville, C., Song, R. X. J., Sowden, D. C., Stark, M. J., Stone, N. R. H., Strunk, T., Sud, A., Swe, K. P., Symons, C. R., Tan, Y. E., Ten Doesschate, T., Thien, S. Y., Thomas, A., Trad, M.-A., Tramontana, A. R., Tsang, J. L. Y., Ulett, K., Underwood, J., van Welzen, B. J., Vazquez-Grande, G., Velasquez Reyes, D. C., Verberk, J. D. M., Voss, L. M., Ward, D., Webb, R. H., Whitmore, T. J., Wieder-Finesod, A., Wilson, H. L., Wilson, E. W., Wong, H. M., Wong She, K., Wuerz, T., Yamamura, D. L., Yeoh, A., Yow, B. L. H., Dymock, M., Mahar, R. K., McGlothlin, A., Marsh, J. A., Davis, J. S. & Tong, S. Y. C. (2026). Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia. The New England journal of medicine, vol. 394, p. 2329-2339.
- Lasry, D., Harrison, L. B., Bamba, R., Corsini, R., Yansouni, C. P., Cheng, M. P., Lee, T. C. & Lawandi, A. (2026). In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces Pseudomonas aeruginosa resistance to antipseudomonal antibiotics (APA). The Journal of antimicrobial chemotherapy, vol. 81.
- Harrison, L. B., Sohani, Z. N., Lasry, D., Cheng, M. P., Lee, T. C., Babiker, A., Kadri, S. S. & Lawandi, A. (2026). Rapid Microbiological Diagnostics for Sepsis: Narrative Review of Current and Prospective Approaches. Critical care explorations, vol. 8, p. e1415.
- Boodman, C., Gupta, N., Cimen, C., van Griensven, J., Cheng, M. P., Yansouni, C. P. & Bottieau, E. (2026). Etiologies of community-acquired febrile illness identified by TaqMan Array Card qPCR on blood samples: a systematic review and meta-analysis. Journal of clinical microbiology, vol. 64, p. e0010126.
- Demir, K. K., Cheng, M. P. & Nelson, J. (2026). Changing Course. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- McDonald, E. G., Cheng, M. P., Davis, J. S., Goodman, A. L., Lawler, P. R., Marsh, J., Mertz, D., Paul, M., Rodriguez-Baño, J., Siegal, D. M., Tong, S. Y., Walls, G., Lee, T. C. & SNAP Global Trial Steering Committee (2025). Is there a role for anticoagulation with dabigatran in S. aureus bacteremia? Protocol for the adjunctive treatment domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) randomised controlled trial. BMJ open, vol. 15, p. e107493.
- Alzahrani, R. S., Vinh, D. C., Rajda, E., Popradi, G., Dufresne, P. J. & Cheng, M. P. (2025). Disseminated Magnusiomyces clavatus (Geotrichum clavatum) infection following allogenic stem cell transplantation: a case report. ASM case reports, vol. 1.
- Mellett, M., Van Riel, J., Corsini, R., Satola, S., Lawandi, A., Caya, C., van Hal, S., Lee, T. C., Papenburg, J., Yansouni, C. P., Babiker, A. & Cheng, M. P. (2025). The combinations of cefazolin with linezolid and cefazolin with clindamycin are indifferent against methicillin-susceptible Staphylococcus aureus. Microbiology spectrum, p. e0176325.
- Walls, G., McGrath, L., Herdman, M. T., Campbell, A. J., Cheng, M. P., Marks, M., Oever, J. T., Sahng, E., Yahav, D., Tong, S. Y. C., Goodman, A. L., Lim, A. G., Bloomfield, M. & Staphylococcus aureus Network Adaptive Platform Trial Early Oral Switch Domain Specific Working Group (2026). Patient-reported perceptions, experiences and preferences around intravenous and oral antibiotics for the treatment of Staphylococcus aureus bacteremia: a descriptive qualitative study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 82, p. e635-e642.
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