Lab Information

Matthew Cheng (MD)

Junior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 40%
 Clinical: 60%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Lethal infectious diseases • opportunistic infections • sepsis • bacteremia

Research Interests

My research focuses on patients with potentially lethal infections, including those with severe manifestations of sepsis, bloodstream infections, and opportunistic infections in immunocompromised hosts. My research program aims to improve morbidity and mortality in these conditions by discovering original treatment strategies through avant-garde clinical trials. I also develop novel diagnostic assays to improve outcomes in these patients, such as using plasma cell-free DNA to monitor the host response to infection and optimize treatment decisions.


Team Members

Name Position

Latest Publications

  1. Sohani, Z. N., Butler-Laporte, G., Aw, A., Belga, S., Benedetti, A., Carignan, A., Cheng, M. P., Coburn, B., Costiniuk, C. T., Ezer, N., Gregson, D., Johnson, A., Khwaja, K., Lawandi, A., Leung, V., Lother, S., MacFadden, D., McGuinty, M., Parkes, L., Qureshi, S., Roy, V., Rush, B., Schwartz, I., So, M., Somayaji, R., Tan, D., Trinh, E., Lee, T. C. & McDonald, E. G. (2022). Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison trial. BMJ open, vol. 12, p. e053039.
  2. Bai, A. D., Lo, C. K., Komorowski, A. S., Suresh, M., Guo, K., Garg, A., Tandon, P., Senecal, J., Corpo, O. D., Stefanova, I., Fogarty, C., Butler-Laporte, G., McDonald, E. G., Cheng, M. P., Morris, A. M., Loeb, M. & Lee, T. C. (2022). Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, vol. 122, p. 405-411.
  3. Tong, S. Y. C., Mora, J., Bowen, A. C., Cheng, M. P., Daneman, N., Goodman, A. L., Heriot, G. S., Lee, T. C., Lewis, R. J., Lye, D. C., Mahar, R. K., Marsh, J., McGlothlin, A., McQuilten, Z., Morpeth, S. C., Paterson, D. L., Price, D. J., Roberts, J. A., Robinson, J. O., van Hal, S. J., Walls, G., Webb, S. A., Whiteway, L., Yahav, D., Davis, J. S. & SNAP study group (2022). The Staphylococcus aureus Network Adaptive Platform Trial protocol: New tools for an old foe. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
  4. Fava, V. M., Bourgey, M., Nawarathna, P. M., Orlova, M., Cassart, P., Vinh, D. C., Cheng, M. P., Bourque, G., Schurr, E. & Langlais, D. (2022). A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19. Science advances, vol. 8, p. eabm2510.
  5. Rocheleau, G. L. Y., Lee, T., Mohammed, Y., Goodlett, D., Burns, K., Cheng, M. P., Tran, K., Sweet, D., Marshall, J., Slutsky, A. S., Murthy, S., Singer, J., Patrick, D. M., Du, B., Peng, Z., Lee, T. C., Boyd, J. H., Walley, K. R., Lamontagne, F., Fowler, R., Winston, B. W., Haljan, G., Vinh, D. C., McGeer, A., Maslove, D., Patrigeon, S. P., Mann, P., Donohoe, K., Hernandez, G., Russell, J. A. & for ARBs CORONA I Investigators (2022). Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19. Critical care medicine.
  6. Papenburg, J., Campbell, J. R., Caya, C., Dion, C., Corsini, R., Cheng, M. P., Menzies, D. & Yansouni, C. P. (2022). Adequacy of Serial Self-performed SARS-CoV-2 Rapid Antigen Detection Testing for Longitudinal Mass Screening in the Workplace. JAMA network open, vol. 5, p. e2210559.
  7. Racine, É., Boivin, G., Longtin, Y., McCormack, D., Decaluwe, H., Savard, P., Cheng, M. P., Hamelin, M.-È., Carbonneau, J., Tadount, F., Adams, K., Bourdin, B., Nantel, S., Gilca, V., Corbeil, J., De Serres, G. & Quach-Thanh, C. (2022). The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers. Influenza and other respiratory viruses, vol. 16, p. 916-925.
  8. Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Tran, K. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D., Singer, J., Patrick, D. M., Marshall, J. C., Burns, K. D., Murthy, S., Mann, P. K., Hernandez, G., Donohoe, K., Rocheleau, G., Russell, J. A. & ARBs CORONA I study investigators (2022). Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort study. CMAJ open, vol. 10, p. E379-E389.
  9. Bai, A. D., Lo, C. K. L., Komorowski, A. S., Suresh, M., Guo, K., Garg, A., Tandon, P., Senecal, J., Del Corpo, O., Stefanova, I., Fogarty, C., Butler-Laporte, G., McDonald, E. G., Cheng, M. P., Morris, A. M., Loeb, M. & Lee, T. C. (2022). What Is the Optimal Follow-up Length for Mortality in Staphylococcus aureus Bacteremia? Observations From a Systematic Review of Attributable Mortality. Open forum infectious diseases, vol. 9, p. ofac096.
  10. Bai, A. D., Lo, C. K. L., Komorowski, A. S., Suresh, M., Guo, K., Garg, A., Tandon, P., Senecal, J., Del Corpo, O., Stefanova, I., Fogarty, C., Butler-Laporte, G., McDonald, E. G., Cheng, M. P., Morris, A. M., Loeb, M. & Lee, T. C. (2022). Staphylococcus aureus bacteraemia mortality: a systematic review and meta-analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 28, p. 1076-1084.
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