Lab Information

Todd Lee (MD)

Clinical Research Unit
Department of Medicine (McGill)

Research Profile

 Fundamental: 30%
 Clinical: 40%
 Epidemiology: 0%
 Evaluation: 30%
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Quality improvement • patient safety • high value healthcare • antibiotic stewardship • polypharmacy

Research Interests

My research focuses on conducting randomized clinical trials designed to improve the treatment of infectious diseases (e.g., C. difficile, COVID-19, S. aureus, Gram-Negative infections) and to innovate in the domains of care of complex hospitalized patients, care of older adults with polypharmacy, and stewardship of healthcare resources (e.g., testing, medications).

Team Members

Name Position

Latest Publications

  1. Prosty, C., Hanula, R., Levin, Y., Bogoch, I. I., McDonald, E. G. & Lee, T. C. (2022). Revisiting the Evidence Base for Modern Day Practice of the Treatment of Toxoplasmic Encephalitis: A Systematic Review and Meta-Analysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
  2. Sohani, Z. N., Butler-Laporte, G., Aw, A., Belga, S., Benedetti, A., Carignan, A., Cheng, M. P., Coburn, B., Costiniuk, C. T., Ezer, N., Gregson, D., Johnson, A., Khwaja, K., Lawandi, A., Leung, V., Lother, S., MacFadden, D., McGuinty, M., Parkes, L., Qureshi, S., Roy, V., Rush, B., Schwartz, I., So, M., Somayaji, R., Tan, D., Trinh, E., Lee, T. C. & McDonald, E. G. (2022). Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison trial. BMJ open, vol. 12, p. e053039.
  3. Albuquerque, A. M., Eckert, I., Tramujas, L., Butler-Laporte, G., McDonald, E. G., Brophy, J. M. & Lee, T. C. (2022). Effect of Tocilizumab, Sarilumab, and Baricitinib on Mortality Among Patients Hospitalized for COVID-19 Treated with Corticosteroids: A Systematic Review and Meta-Analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
  4. Morris, A. M. & Lee, T. C. (2022). Nirmatrelvir for Nonhospitalized Adults with Covid-19. The New England journal of medicine, vol. 387, p. 474-475.
  5. Williams, J., Gingras, M.-A., Dubé, R., Lee, T. C. & McDonald, E. G. (2022). Patient empowerment brochures to increase gabapentinoid deprescribing: protocol for the prospective, controlled before-and-after GABA-WHY trial. CMAJ open, vol. 10, p. E652-E656.
  6. Ross, S. B., Bortolussi-Courval, É., Hanula, R., Lee, T. C., Goodwin Wilson, M. & McDonald, E. G. (2022). Drug Interactions With Nirmatrelvir-Ritonavir in Older Adults Using Multiple Medications. JAMA network open, vol. 5, p. e2220184.
  7. Perri, G.-A., Bortolussi-Courval, É., Brinton, C. D., Berall, A., Santiago, A. T., Morcos, M., Lee, T. C. & McDonald, E. G. (2022). MedSafer to Support Deprescribing for Residents of Long-Term Care: a Mixed-Methods Study. Canadian geriatrics journal : CGJ, vol. 25, p. 175-182.
  8. Bai, A. D., Lo, C. K., Komorowski, A. S., Suresh, M., Guo, K., Garg, A., Tandon, P., Senecal, J., Corpo, O. D., Stefanova, I., Fogarty, C., Butler-Laporte, G., McDonald, E. G., Cheng, M. P., Morris, A. M., Loeb, M. & Lee, T. C. (2022). Staphylococcus aureus bacteremia mortality across country income groups: A secondary analysis of a systematic review. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, vol. 122, p. 405-411.
  9. Tong, S. Y. C., Mora, J., Bowen, A. C., Cheng, M. P., Daneman, N., Goodman, A. L., Heriot, G. S., Lee, T. C., Lewis, R. J., Lye, D. C., Mahar, R. K., Marsh, J., McGlothlin, A., McQuilten, Z., Morpeth, S. C., Paterson, D. L., Price, D. J., Roberts, J. A., Robinson, J. O., van Hal, S. J., Walls, G., Webb, S. A., Whiteway, L., Yahav, D., Davis, J. S. & SNAP study group (2022). The Staphylococcus aureus Network Adaptive Platform Trial protocol: New tools for an old foe. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
  10. Rocheleau, G. L. Y., Lee, T., Mohammed, Y., Goodlett, D., Burns, K., Cheng, M. P., Tran, K., Sweet, D., Marshall, J., Slutsky, A. S., Murthy, S., Singer, J., Patrick, D. M., Du, B., Peng, Z., Lee, T. C., Boyd, J. H., Walley, K. R., Lamontagne, F., Fowler, R., Winston, B. W., Haljan, G., Vinh, D. C., McGeer, A., Maslove, D., Patrigeon, S. P., Mann, P., Donohoe, K., Hernandez, G., Russell, J. A. & for ARBs CORONA I Investigators (2022). Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19. Critical care medicine.
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