Lab Information
Todd Lee (MD)
ScientistClinical Research Unit
Department of Medicine (McGill)
Research Profile
https://www.drtoddlee.com/
Keywords
Quality improvement • patient safety • high value healthcare • antibiotic stewardship • polypharmacyResearch Interests
My research focuses on conducting randomized clinical trials designed to improve the treatment of infectious diseases (e.g., C. difficile, COVID-19, S. aureus, Gram-Negative infections) and to innovate in the domains of care of complex hospitalized patients, care of older adults with polypharmacy, and stewardship of healthcare resources (e.g., testing, medications).Team Members
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Latest Publications
- Cabanilla, M. G., Ghanem, B., Jegorović, B., Lee, T. C., Chahine, E. B., Anderson, D. T., Salgado, N. K., Eudy, J., Singh, H. K., Muyidi, A. A., Astorri, R., Maraolo, A. E., Antolí Royo, A. C., Mena Lora, A. J., Pimentel, B. V. & Spellberg, B. (2026). Universal high-dose meropenem for antimicrobial-resistant Gram-negative infections: evidence or overreach?. European journal of hospital pharmacy : science and practice.
- Prosty, C., Desormeau, B., Lee, T. C. & McDonald, E. G. (2026). Diagnosis, treatment, and prophylaxis of Clostridioides difficile infections: A cross-sectional survey of Canadian clinicians. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 11, p. 37-50.
- Hamilton, F., Lee, T. C., Davey Smith, G., Hartwig, F. P. & Butler-Laporte, G. (2026). The illusion of causality: Instruments, colliders, and acute kidney injury in sepsis. American journal of respiratory and critical care medicine.
- Ross, S. B., Bortolussi-Courval, É., Juhásová, Z., Weir, D. L., Wilson, A. G., Lee, T. C., McDonald, E. G. & Wilson, M. G. (2026). Measuring Medication Related Harm: Proposed Guidance for Adverse Drug Event Adjudication to Harmonize Outcomes in Deprescribing Research. Journal of the American Geriatrics Society.
- Shechtman, L., Murthy, S., Tremblay, A., Silverman, M., Lee, T. C., Daley, P., Pinto, R., Fowler, R. A. & Canadian Treatments for COVID-19 (CATCO) investigators, the Association of Medical Microbiology and Infectious Disease Canada (AMMI) Clinical Research Network, and the Canadian Critical Care Trials Group (2025). Extended-duration dexamethasone for the treatment of hospitalized COVID-19 patients in Canada: A randomized clinical trial. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 10, p. 299-303.
- Butler, C. C., Pinto, A. D., Harris, V., Holmes, J., Rahman, N. M., Cureton, L., Hayward, G., Richards, D. B., Lowe, D. M., Standing, J. F., Breuer, J., Hood, K., Png, M. E., Petrou, S., Dorward, J., Patel, M. G., Thomas, N. P. B., Evans, P., Hart, N. D., Jani, B. D., Hosseini, B., Murthy, S., McBrien, K., Condon, A., McDonald, E. G., Daley, P., Greiver, M., da Costa, B. R., Selby, P., Jüni, P., Lee, T. C., Shi, H., Detry, M. A., Saunders, C. T., Fitzgerald, M., Berry, N. S., Saville, B. R., Khoo, S. H., Nguyen-Van-Tam, J. S., Hobbs, F. D. R., Yu, L.-M., Little, P. & PANORAMIC Trial and CanTreatCOVID Trial Collaborative Groups (2026). Oral Nirmatrelvir-Ritonavir for Covid-19 in Higher-Risk Outpatients. The New England journal of medicine, vol. 394, p. 1583-1594.
- Spellberg, B., Ghanem, B., Morante-Ruiz, M., Bortolussi-Courval, É., Makam, A. N., Ergenc, Z., Riccardi, N., Meyer-Sautter, P., Alharbi, S., Rocha-Pereira, N., Centor, R. M., Ryder, J., Bhoojhawon, G., Ahmed, I., Cabanilla, M. G., Almeida, F., Pimentel, B. V., Starkey, J., Costa, R. P. L., Maraolo, A. E., Tong, S. Y. C., Anderson, D. T., Murri, R., McDonald, E. G. & Lee, T. C. (2026). Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS-IDSA Debate. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Hosseini, B., Condon, A., da Costa, B. R., Daley, P., Greiver, M., Jüni, P., Lee, T. C., McBrien, K., McDonald, E. G., Murthy, S., Selby, P. & Pinto, A. D. (2026). Lessons learned and recommendations from the Canadian adaptive platform trial of treatments for COVID in community settings (CanTreatCOVID). Contemporary clinical trials, vol. 165, p. 108303.
- Yahav, D., Pinto, R., Cook, D., Davis, J., Duan, E., Hoffman, T., Lee, T. C., McDonald, E. G., Morpeth, S., Muscedere, J., Sligl, W., Wuerz, T., Fowler, R. A., Daneman, N. & BALANCE consortium (2026). Duration of therapy for Pseudomonas aeruginosa bacteremia - a post hoc subgroup analysis from the BALANCE randomized controlled trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- McDonald, E. G., Butler-Laporte, G., Brophy, J. M., Elsayed, S., Frenette, C., Huseen, I., Loo, V. G., Moran, K., Coburn, B., Hota, S. S., Longtin, Y., Kong, L. Y., Muller, M. P., Steiner, T. S., Valiquette, L., Daneman, N., Daley, P., Nott, C., MacFadden, D. R., Kandel, C. E., Chen, Y., Perez-Patrigeon, S., Lee, T. C. & TAPER-V Team (2026). Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial. JAMA network open, vol. 9, p. e2560495.
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