Lab Information
Donald Vinh (MD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Primary (genetic) immunodeficiencies • molecular genetics • translational research • immunity • infectionsResearch Interests
My research focuses on identifying how genetic defects of immunity predispose patients to infectious diseases. A fundamental enigma in the field of infectious diseases is the variability in clinical outcomes between individuals exposed to the same microbial environment. For a given microbe, what distinguishes those who are “well” or “mildly symptomatic” from those who develop “life-threatening disease”? Accumulating evidence demonstrates that mutations in critical genes can cause a variety of immunodeficiencies, resulting in human susceptibility to specific infectious diseases. My research program is distinguished by the unique ability to bring patients (and relevant family members) with unusual, severe or recalcitrant infections into the laboratory and meticulously study them, through state-of-the-art genomic and functional immunologic studies and model systems, to delineate fundamental principles of human immunobiology. In so doing, we aim to translate our findings into innovative therapies directly relevant for patients, and to discover novel diseases of human immunity.Team Members
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Latest Publications
- Bastard, P., Vazquez, S., Liu, J., Laurie, M. T., Wang, C. Y., Gervais, A., Le Voyer, T., Bizien, L., Zamecnik, C., Philippot, Q., Rosain, J., Catherinot, E., Willmore, A., Mitchell, A. M., Bair, R., Garçon, P., Kenney, H., Fekkar, A., Salagianni, M., Poulakou, G., Siouti, E., Sahanic, S., Tancevski, I., Weiss, G., Nagl, L., Manry, J., Duvlis, S., Arroyo-Sánchez, D., Paz Artal, E., Rubio, L., Perani, C., Bezzi, M., Sottini, A., Quaresima, V., Roussel, L., Vinh, D. C., Reyes, L. F., Garzaro, M., Hatipoglu, N., Boutboul, D., Tandjaoui-Lambiotte, Y., Borghesi, A., Aliberti, A., Cassaniti, I., Venet, F., Monneret, G., Halwani, R., Sharif-Askari, N. S., Danielson, J., Burrel, S., Morbieu, C., Stepanovskyy, Y., Bondarenko, A., Volokha, A., Boyarchuk, O., Gagro, A., Neuville, M., Neven, B., Keles, S., Hernu, R., Bal, A., Novelli, A., Novelli, G., Saker, K., Ailioaie, O., Antolí, A., Jeziorski, E., Rocamora-Blanch, G., Teixeira, C., Delaunay, C., Lhuillier, M., Le Turnier, P., Zhang, Y., Mahevas, M., Pan-Hammarström, Q., Abolhassani, H., Bompoil, T., Dorgham, K., COVID HGE consortium † , French COVID study group † , COMET consortium † , Gorochov, G., Laouenan, C., Rodríguez-Gallego, C., Ng, L. F. P., Renia, L., Pujol, A., Belot, A., Raffi, F., Allende, L. M., Martinez-Picado, J., Ozcelik, T., Keles, S., Imberti, L., Notarangelo, L. D., Troya, J., Solanich, X., Zhang, S.-Y., Puel, A., Wilson, M. R., Trouillet-Assant, S., Abel, L., Jouanguy, E., Ye, C. J., Cobat, A., Thompson, L. M., Andreakos, E., Zhang, Q., Anderson, M. S., Casanova, J.-L. & DeRisi, J. L. (2022). Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs. Science immunology, p. eabp8966.
- Fava, V. M., Bourgey, M., Nawarathna, P. M., Orlova, M., Cassart, P., Vinh, D. C., Cheng, M. P., Bourque, G., Schurr, E. & Langlais, D. (2022). A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19. Science advances, vol. 8, p. eabm2510.
- Rocheleau, G. L. Y., Lee, T., Mohammed, Y., Goodlett, D., Burns, K., Cheng, M. P., Tran, K., Sweet, D., Marshall, J., Slutsky, A. S., Murthy, S., Singer, J., Patrick, D. M., Du, B., Peng, Z., Lee, T. C., Boyd, J. H., Walley, K. R., Lamontagne, F., Fowler, R., Winston, B. W., Haljan, G., Vinh, D. C., McGeer, A., Maslove, D., Patrigeon, S. P., Mann, P., Donohoe, K., Hernandez, G., Russell, J. A. & for ARBs CORONA I Investigators (2022). Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19. Critical care medicine.
- Manry, J., Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Michailidis, E., Hoffmann, H.-H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., de Prost, N., Tandjaoui-Lambiotte, Y., Luyt, C.-E., Amador-Borrero, B., Gaudet, A., Poissy, J., Morel, P., Richard, P., Cognasse, F., Troya, J., Trouillet-Assant, S., Belot, A., Saker, K., Garçon, P., Rivière, J. G., Lagier, J.-C., Gentile, S., Rosen, L. B., Shaw, E., Morio, T., Tanaka, J., Dalmau, D., Tharaux, P.-L., Sene, D., Stepanian, A., Mégarbane, B., Triantafyllia, V., Fekkar, A., Heath, J. R., Franco, J. L., Anaya, J.-M., Solé-Violán, J., Imberti, L., Biondi, A., Bonfanti, P., Castagnoli, R., Delmonte, O. M., Zhang, Y., Snow, A. L., Holland, S. M., Biggs, C. M., Moncada-Vélez, M., Arias, A. A., Lorenzo, L., Boucherit, S., Anglicheau, D., Planas, A. M., Haerynck, F., Duvlis, S., Ozcelik, T., Keles, S., Bousfiha, A. A., El Bakkouri, J., Ramirez-Santana, C., Paul, S., Pan-Hammarström, Q., Hammarström, L., Dupont, A., Kurolap, A., Metz, C. N., Aiuti, A., Casari, G., Lampasona, V., Ciceri, F., Barreiros, L. A., Dominguez-Garrido, E., Vidigal, M., Zatz, M., van de Beek, D., Sahanic, S., Tancevski, I., Stepanovskyy, Y., Boyarchuk, O., Nukui, Y., Tsumura, M., Vidaur, L., Tangye, S. G., Burrel, S., Duffy, D., Quintana-Murci, L., Klocperk, A., Kann, N. Y., Shcherbina, A., Lau, Y.-L., Leung, D., Coulongeat, M., Marlet, J., Koning, R., Reyes, L. F., Chauvineau-Grenier, A., Venet, F., Monneret, G., Nussenzweig, M. C., Arrestier, R., Boudhabhay, I., Baris-Feldman, H., Hagin, D., Wauters, J., Meyts, I., Dyer, A. H., Kennelly, S. P., Bourke, N. M., Halwani, R., Sharif-Askari, F. S., Dorgham, K., Sallette, J., Sedkaoui, S. M., AlKhater, S., Rigo-Bonnin, R., Morandeira, F., Roussel, L., Vinh, D. C., Erikstrup, C., Condino-Neto, A., Prando, C., Bondarenko, A., Spaan, A. N., Gilardin, L., Fellay, J., Lyonnet, S., Bilguvar, K., Lifton, R. P., Mane, S., HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest Group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CP-COVID-19 Group, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement Français du Sang Study group, Anderson, M. S., Boisson, B., Béziat, V., Zhang, S.-Y., Andreakos, E., Hermine, O., Pujol, A., Peterson, P., Mogensen, T. H., Rowen, L., Mond, J., Debette, S., de Lamballerie, X., Burdet, C., Bouadma, L., Zins, M., Soler-Palacin, P., Colobran, R., Gorochov, G., Solanich, X., Susen, S., Martinez-Picado, J., Raoult, D., Vasse, M., Gregersen, P. K., Piemonti, L., Rodríguez-Gallego, C., Notarangelo, L. D., Su, H. C., Kisand, K., Okada, S., Puel, A., Jouanguy, E., Rice, C. M., Tiberghien, P., Zhang, Q., Casanova, J.-L., Abel, L. & Cobat, A. (2022). The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies. Proceedings of the National Academy of Sciences of the United States of America, vol. 119, p. e2200413119.
- Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Tran, K. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D., Singer, J., Patrick, D. M., Marshall, J. C., Burns, K. D., Murthy, S., Mann, P. K., Hernandez, G., Donohoe, K., Rocheleau, G., Russell, J. A. & ARBs CORONA I study investigators (2022). Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort study. CMAJ open, vol. 10, p. E379-E389.
- Merati, N., Sivachandran, S., Jfri, A., Ben-Shoshan, M., Vinh, D. C., Popradi, G. & Litvinov, I. V. (2022). Plerixafor on a WHIM - Promise or Fantasy of a New CXCR4 Inhibitor for This Rare, but Important Syndrome?. Skin therapy letter, vol. 27, p. 1-5.
- Kaufmann, E., Khan, N., Tran, K. A., Ulndreaj, A., Pernet, E., Fontes, G., Lupien, A., Desmeules, P., McIntosh, F., Abow, A., Moorlag, S. J. C. F. M., Debisarun, P., Mossman, K., Banerjee, A., Karo-Atar, D., Sadeghi, M., Mubareka, S., Vinh, D. C., King, I. L., Robbins, C. S., Behr, M. A., Netea, M. G., Joubert, P. & Divangahi, M. (2022). BCG vaccination provides protection against IAV but not SARS-CoV-2. Cell reports, vol. 38, p. 110502.
- Vinh, D. C., Gouin, J.-P., Cruz-Santiago, D., Canac-Marquis, M., Bernier, S., Bobeuf, F., Sengupta, A., Brassard, J.-P., Guerra, A., Dziarmaga, R., Perez, A., Sun, Y., Li, Y., Roussel, L., Langelier, M. J., Ke, D., Arnold, C., Whelan, M., Pelchat, M., Langlois, M.-A., Zhang, X., Mazer, B. D. & COVID-19 Immunity Task Force and UNCoVER Investigators (2022). Real-world serological responses to extended-interval and heterologous COVID-19 mRNA vaccination in frail, older people (UNCoVER): an interim report from a prospective observational cohort study. The Lancet. Healthy longevity, vol. 3, p. e166-e175.
- Mohammed, Y., Goodlett, D. R., Cheng, M. P., Vinh, D. C., Lee, T. C., Mcgeer, A., Sweet, D., Tran, K., Lee, T., Murthy, S., Boyd, J. H., Singer, J., Walley, K. R., Patrick, D. M., Quan, C., Ismail, S., Amar, L., Pal, A., Bassawon, R., Fesdekjian, L., Gou, K., Lamontagne, F., Marshall, J., Haljan, G., Fowler, R., Winston, B. W., Russell, J. A. & ARBs CORONA I (2022). Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19. Journal of proteome research, vol. 21, p. 975-992.
- Kaufmann, E., Landekic, M., Downey, J., Chronopoulos, J., Teimouri Nezhad, S., Tran, K., Vinh, D. C., Barreiro, L. B. & Divangahi, M. (2022). Lack of evidence for intergenerational inheritance of immune resistance to infections. Nature immunology, vol. 23, p. 203-207.
See also
