Lab Information
Erwin Schurr (PhD)
Senior ScientistCentre for Translational Biology
Department of Human Genetics (McGill)
Research Profile
Keywords
Tuberculosis • leprosy • complex traits • transcriptomics • systems biologyResearch Interests
My research focuses on the identification and evaluation of host genetic factors in tuberculosis and leprosy. We are working with partner groups in endemic countries for those diseases and are applying modern concepts of genetics, genomics and sytems biology to our analyses.Team Members
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Latest Publications
- Rivière, P., Le Chevillier, A., Rullier, A., Marty, M., Schurr, E., Lapuyade, B., Célerier, B., Fernandez, B., Bessissow, T., Treton, X., Uzzan, M., Poullenot, F., Berger, A., Zerbib, F. & Laharie, D. (2023). Deep ulcers are associated with increased C-reactive protein in active ulcerative colitis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
- Su, C.-Y., Zhou, S., Gonzalez-Kozlova, E., Butler-Laporte, G., Brunet-Ratnasingham, E., Nakanishi, T., Jeon, W., Morrison, D. R., Laurent, L., Afilalo, J., Afilalo, M., Henry, D., Chen, Y., Carrasco-Zanini, J., Farjoun, Y., Pietzner, M., Kimchi, N., Afrasiabi, Z., Rezk, N., Bouab, M., Petitjean, L., Guzman, C., Xue, X., Tselios, C., Vulesevic, B., Adeleye, O., Abdullah, T., Almamlouk, N., Moussa, Y., DeLuca, C., Duggan, N., Schurr, E., Brassard, N., Durand, M., Del Valle, D. M., Thompson, R., Cedillo, M. A., Schadt, E., Nie, K., Simons, N. W., Mouskas, K., Zaki, N., Patel, M., Xie, H., Harris, J., Marvin, R., Cheng, E., Tuballes, K., Argueta, K., Scott, I., Mount Sinai COVID-19 Biobank Team, Greenwood, C. M. T., Paterson, C., Hinterberg, M. A., Langenberg, C., Forgetta, V., Pineau, J., Mooser, V., Marron, T., Beckmann, N. D., Kim-Schulze, S., Charney, A. W., Gnjatic, S., Kaufmann, D. E., Merad, M. & Richards, J. B. (2023). Circulating proteins to predict COVID-19 severity. Scientific reports, vol. 13, p. 6236.
- Dallmann-Sauer, M., Xu, Y. Z., da Costa, A. L. F., Tao, S., Gomes, T. A., Prata, R. B. D. S., Correa-Macedo, W., Manry, J., Alcaïs, A., Abel, L., Cobat, A., Fava, V. M., Pinheiro, R. O., Lara, F. A., Probst, C. M., Mira, M. T. & Schurr, E. (2023). Allele-dependent interaction of LRRK2 and NOD2 in leprosy. PLoS pathogens, vol. 19, p. e1011260.
- Mendonca, L. E., Pernet, E., Khan, N., Sanz, J., Kaufmann, E., Downey, J., Grant, A., Orlova, M., Schurr, E., Krawczyk, C., Jones, R. G., Barreiro, L. B. & Divangahi, M. (2022). Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection. Frontiers in immunology, vol. 13, p. 1044592.
- Butler-Laporte, G., Gonzalez-Kozlova, E., Su, C.-Y., Zhou, S., Nakanishi, T., Brunet-Ratnasingham, E., Morrison, D., Laurent, L., Aflalo, J., Aflalo, M., Henry, D., Chen, Y., Carrasco-Zanini, J., Farjoun, Y., Pietzner, M., Kimchi, N., Afrasiabi, Z., Rezk, N., Bouab, M., Petitjean, L., Guzman, C., Xue, X., Tselios, C., Vulesevic, B., Adeleye, O., Abdullah, T., Almamlouk, N., Moussa, Y., DeLuca, C., Duggan, N., Schurr, E., Brassard, N., Durand, M., Del Valle, D. M., Thompson, R., Cedillo, M. A., Schadt, E., Nie, K., Simons, N. W., Mouskas, K., Zaki, N., Patel, M., Xie, H., Harris, J., Marvin, R., Cheng, E., Tuballes, K., Argueta, K., Scott, I., Mount Sinai COVID-19 Biobank Team, Greenwood, C. M. T., Paterson, C., Hinterberg, M., Langenberg, C., Forgetta, V., Mooser, V., Marron, T., Beckmann, N. D., Kenigsberg, E., Charney, A. W., Kim-Schulze, S., Merad, M., Kaufmann, D. E., Gnjatic, S. & Richards, J. B. (2022). Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals. Clinical proteomics, vol. 19, p. 40.
- Burns, L., Giannakopoulou, N., Zhu, L., Xu, Y. Z., Khan, R. H., Bekal, S., Schurr, E., Schmeing, T. M. & Gruenheid, S. (2023). The bacterial virulence factor NleA undergoes host-mediated O-linked glycosylation. Molecular microbiology, vol. 119, p. 161-173.
- Butler-Laporte, G., Gonzalez-Kozlova, E., Su, C.-Y., Zhou, S., Nakanishi, T., Brunet-Ratnasingham, E., Morrison, D., Laurent, L., Afilalo, J., Afilalo, M., Henry, D., Chen, Y., Carrasco-Zanini, J., Farjoun, Y., Pietzner, M., Kimchi, N., Afrasiabi, Z., Rezk, N., Bouab, M., Petitjean, L., Guzman, C., Xue, X., Tselios, C., Vulesevic, B., Adeleye, O., Abdullah, T., Almamlouk, N., Moussa, Y., DeLuca, C., Duggan, N., Schurr, E., Brassard, N., Durand, M., Del Valle, D. M., Thompson, R., Cedillo, M. A., Schadt, E., Nie, K., Simons, N. W., Mouskas, K., Zaki, N., Patel, M., Xie, H., Harris, J., Marvin, R., Cheng, E., Tuballes, K., Argueta, K., Scott, I., Mount Sinai COVID-19 Biobank Team, Greenwood, C. M. T., Paterson, C., Hinterberg, M., Langenberg, C., Forgetta, V., Mooser, V., Marron, T., Beckmann, N., Kenigsberg, E., Charney, A. W., Kim-Schulze, S., Merad, M., Kaufmann, D. E., Gnjatic, S. & Richards, J. B. (2022). The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals. Clinical proteomics, vol. 19, p. 34.
- Fava, V. M., Bourgey, M., Nawarathna, P. M., Orlova, M., Cassart, P., Vinh, D. C., Cheng, M. P., Bourque, G., Schurr, E. & Langlais, D. (2022). A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19. Science advances, vol. 8, p. eabm2510.
- Fava, V. M., Dallmann-Sauer, M., Orlova, M., Correa-Macedo, W., Van Thuc, N., Thai, V. H., Alcaïs, A., Abel, L., Cobat, A. & Schurr, E. (2021). Deep resequencing identifies candidate functional genes in leprosy GWAS loci. PLoS neglected tropical diseases, vol. 15, p. e0010029.
- Correa-Macedo, W., Fava, V. M., Orlova, M., Cassart, P., Olivenstein, R., Sanz, J., Xu, Y. Z., Dumaine, A., Sindeaux, R. H., Yotova, V., Pacis, A., Girouard, J., Kalsdorf, B., Lange, C., Routy, J.-P., Barreiro, L. B. & Schurr, E. (2021). Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis. The Journal of clinical investigation, vol. 131.
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