Lab Information
Donald Vinh (MD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Primary (genetic) immunodeficiencies • molecular genetics • translational research • immunity • infectionsResearch Interests
My research focuses on identifying how genetic defects of immunity predispose patients to infectious diseases. A fundamental enigma in the field of infectious diseases is the variability in clinical outcomes between individuals exposed to the same microbial environment. For a given microbe, what distinguishes those who are “well” or “mildly symptomatic” from those who develop “life-threatening disease”? Accumulating evidence demonstrates that mutations in critical genes can cause a variety of immunodeficiencies, resulting in human susceptibility to specific infectious diseases. My research program is distinguished by the unique ability to bring patients (and relevant family members) with unusual, severe or recalcitrant infections into the laboratory and meticulously study them, through state-of-the-art genomic and functional immunologic studies and model systems, to delineate fundamental principles of human immunobiology. In so doing, we aim to translate our findings into innovative therapies directly relevant for patients, and to discover novel diseases of human immunity.Team Members
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Latest Publications
- Roussel, L., Bernier, S., Perez, A., Sun, Y., Angers, I., Laneuville, P., Lawandi, A. & Vinh, D. C. (2024). Impaired apoptosis underlying lymphoproliferative disease in a patient with haploinsufficient NFKB1 deficiency. British journal of haematology, vol. 205, p. 2089-2093.
- Schweitzer, L., Barkati, S., Laneuville, P., Fox, S. & Vinh, D. C. (2024). Treatment of Progressive Multifocal Leukoencephalopathy with IL-2 and Mirtazapine. Journal of clinical immunology, vol. 44, p. 97.
- Lee, C. H., Banoei, M. M., Ansari, M., Cheng, M. P., Lamontagne, F., Griesdale, D., Lasry, D. E., Demir, K., Dhingra, V., Tran, K. C., Lee, T., Burns, K., Sweet, D., Marshall, J., Slutsky, A., Murthy, S., Singer, J., Patrick, D. M., Lee, T. C., Boyd, J. H., Walley, K. R., Fowler, R., Haljan, G., Vinh, D. C., Mcgeer, A., Maslove, D., Mann, P., Donohoe, K., Hernandez, G., Rocheleau, G., Trahtemberg, U., Kumar, A., Lou, M., Dos Santos, C., Baker, A., Russell, J. A., Winston, B. W. & *ARBs CORONA I. Investigators (2024). Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia. Critical care (London, England), vol. 28, p. 63.
- Grant, J. M., Lam, J., Goyal, S. V., Lother, S., Kassim, S. S., Lee, S. B., Chan, J., Girouard, G., Barrett, L., Takaya, S., Piszczek, J., Vinh, D. C., Findlater, A. R. & Saxinger, L. (2024). AMMI Canada Practice Point: Updated recommendations for treatment of adults with symptomatic COVID-19 in 2023-2024. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 8, p. 245-252.
- Bastard, P., Gervais, A., Taniguchi, M., Saare, L., Särekannu, K., Le Voyer, T., Philippot, Q., Rosain, J., Bizien, L., Asano, T., Garcia-Prat, M., Parra-Martínez, A., Migaud, M., Tsumura, M., Conti, F., Belot, A., Rivière, J. G., Morio, T., Tanaka, J., Javouhey, E., Haerynck, F., Duvlis, S., Ozcelik, T., Keles, S., Tandjaoui-Lambiotte, Y., Escoda, S., Husain, M., Pan-Hammarström, Q., Hammarström, L., Ahlijah, G., Abi Haidar, A., Soudee, C., Arseguel, V., Abolhassani, H., Sahanic, S., Tancevski, I., Nukui, Y., Hayakawa, S., Chrousos, G. P., Michos, A., Tatsi, E.-B., Filippatos, F., Rodriguez-Palmero, A., Troya, J., Tipu, I., Meyts, I., Roussel, L., Ostrowski, S. R., Schidlowski, L., Prando, C., Condino-Neto, A., Cheikh, N., Bousfiha, A. A., El Bakkouri, J., COVID Clinicians, GEN-COVID Study Group, COVID Human Genetic Effort, Peterson, P., Pujol, A., Lévy, R., Quartier, P., Vinh, D. C., Boisson, B., Béziat, V., Zhang, S.-Y., Borghesi, A., Pession, A., Andreakos, E., Marr, N., Mentis, A.-A., Mogensen, T. H., Rodríguez-Gallego, C., Soler-Palacin, P., Colobran, R., Tillmann, V., Neven, B., Trouillet-Assant, S., Brodin, P., Abel, L., Jouanguy, E., Zhang, Q., Martinón-Torres, F., Salas, A., Gómez-Carballa, A., Gonzalez-Granado, L. I., Kisand, K., Okada, S., Puel, A., Cobat, A. & Casanova, J.-L. (2024). Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children. The Journal of experimental medicine, vol. 221.
- Vinh, D. C. (2024). From Mendel to mycoses: Immuno-genomic warfare at the human-fungus interface. Immunological reviews, vol. 322, p. 28-52.
- Mohammed, Y., Tran, K., Carlsten, C., Ryerson, C., Wong, A., Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D., Singer, J., Patrick, D. M., Marshall, J. C., Murthy, S., Jain, F., Borchers, C. H., Goodlett, D. R., Levin, A., Russell, J. A. & ARBs CORONA I Consortium (2024). Proteomic Evolution from Acute to Post-COVID-19 Conditions. Journal of proteome research, vol. 23, p. 52-70.
- Roussel, L., Pham-Huy, A., Yu, A. C., Venkateswaran, S., Perez, A., Bourdel, G., Sun, Y., Villavicencio, S. T., Bernier, S., Li, Y., Kazimerczak-Brunet, M., Alattar, R., Déry, M.-A., Shapiro, A. J., Penner, J. & Vinh, D. C. (2023). A Novel Homozygous Mutation Causing Complete TYK2 Deficiency, with Severe Respiratory Viral Infections, EBV-Driven Lymphoma, and Jamestown Canyon Viral Encephalitis. Journal of clinical immunology, vol. 43, p. 2011-2021.
- Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Tran, K. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D. M., Singer, J., Patrick, D. M., Marshall, J. C., Burns, K. D., Murthy, S., Mann, P. K., Hernandez, G., Donohoe, K., Russell, J. A. & for ARBs CORONA I (2023). Outcomes and characteristics of patients hospitalized for COVID-19 in British Columbia, Ontario and Quebec during the Omicron wave. CMAJ open, vol. 11, p. E672-E683.
- Giralt, S., Jolles, S., Kerre, T., Lazarus, H. M., Mustafa, S. S., Papanicolaou, G. A., Ria, R., Vinh, D. C. & Wingard, J. R. (2023). Recommendations for Management of Secondary Antibody Deficiency in Multiple Myeloma. Clinical lymphoma, myeloma & leukemia, vol. 23, p. 719-732.
See also
