Lab Information
Erwin Schurr (PhD)
Senior ScientistCentre for Translational Biology
Department of Human Genetics (McGill)
Research Profile
Keywords
Tuberculosis • leprosy • complex traits • transcriptomics • systems biologyResearch Interests
My research focuses on the identification and evaluation of host genetic factors in tuberculosis and leprosy. We are working with partner groups in endemic countries for those diseases and are applying modern concepts of genetics, genomics and sytems biology to our analyses.Team Members
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Latest Publications
- Correa-Macedo, W., Dallmann-Sauer, M., Orlova, M., Manry, J., Fava, V. M., Huong, N. T., Ba, N. N., Van Thuc, N., Thai, V. H. & Schurr, E. (2024). Transcriptome immune-regulatory differences between leprosy patients and type 1 reaction patients, before onset of symptoms. PLoS neglected tropical diseases, vol. 18, p. e0011866.
- Moodley, S., Kroon, E., Naidoo, C. C., Nyawo, G. R., Wu, B. G., Naidoo, S., Chiyaka, T. L., Tshivhula, H., Singh, S., Li, Y., Warren, R. M., Hoal, E. G., Schurr, E., Clemente, J. C., Segal, L. N., Möller, M. & Theron, G. (2024). Latent Tuberculosis Infection Is Associated with an Enrichment of Short-Chain Fatty Acid-Producing Bacteria in the Stool of Women Living with HIV. Microorganisms, vol. 12.
- Alexandrova, Y., Yero, A., Olivenstein, R., Orlova, M., Schurr, E., Estaquier, J., Costiniuk, C. T. & Jenabian, M.-A. (2024). Dynamics of pulmonary mucosal cytotoxic CD8 T-cells in people living with HIV under suppressive antiretroviral therapy. Respiratory research, vol. 25, p. 240.
- Moodley, S., Kroon, E., Naidoo, C. C., Nyawo, G. R., Wu, B. G., Naidoo, S., Chiyaka, T. L., Tshivhula, H., Singh, S., Li, Y., Warren, R. M., Hoal, E. G., Schurr, E., Clemente, J., Segal, L. N., Möller, M. & Theron, G. (2024). Latent tuberculosis infection is associated with an enrichment of short chain fatty acid producing bacteria in the stool of women living with HIV. Research square.
- Kroon, E. E., Correa-Macedo, W., Evans, R., Seeger, A., Engelbrecht, L., Kriel, J. A., Loos, B., Okugbeni, N., Orlova, M., Cassart, P., Kinnear, C. J., Tromp, G. C., Möller, M., Wilkinson, R. J., Coussens, A. K., Schurr, E. & Hoal, E. G. (2023). Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV. PLoS genetics, vol. 19, p. e1010888.
- Rivière, P., Le Chevillier, A., Rullier, A., Marty, M., Schurr, E., Lapuyade, B., Célerier, B., Fernandez, B., Bessissow, T., Treton, X., Uzzan, M., Poullenot, F., Berger, A., Zerbib, F. & Laharie, D. (2023). Deep ulcers are associated with increased C-reactive protein in active ulcerative colitis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 55, p. 1194-1200.
- Su, C.-Y., Zhou, S., Gonzalez-Kozlova, E., Butler-Laporte, G., Brunet-Ratnasingham, E., Nakanishi, T., Jeon, W., Morrison, D. R., Laurent, L., Afilalo, J., Afilalo, M., Henry, D., Chen, Y., Carrasco-Zanini, J., Farjoun, Y., Pietzner, M., Kimchi, N., Afrasiabi, Z., Rezk, N., Bouab, M., Petitjean, L., Guzman, C., Xue, X., Tselios, C., Vulesevic, B., Adeleye, O., Abdullah, T., Almamlouk, N., Moussa, Y., DeLuca, C., Duggan, N., Schurr, E., Brassard, N., Durand, M., Del Valle, D. M., Thompson, R., Cedillo, M. A., Schadt, E., Nie, K., Simons, N. W., Mouskas, K., Zaki, N., Patel, M., Xie, H., Harris, J., Marvin, R., Cheng, E., Tuballes, K., Argueta, K., Scott, I., Mount Sinai COVID-19 Biobank Team, Greenwood, C. M. T., Paterson, C., Hinterberg, M. A., Langenberg, C., Forgetta, V., Pineau, J., Mooser, V., Marron, T., Beckmann, N. D., Kim-Schulze, S., Charney, A. W., Gnjatic, S., Kaufmann, D. E., Merad, M. & Richards, J. B. (2023). Circulating proteins to predict COVID-19 severity. Scientific reports, vol. 13, p. 6236.
- Dallmann-Sauer, M., Xu, Y. Z., da Costa, A. L. F., Tao, S., Gomes, T. A., Prata, R. B. D. S., Correa-Macedo, W., Manry, J., Alcaïs, A., Abel, L., Cobat, A., Fava, V. M., Pinheiro, R. O., Lara, F. A., Probst, C. M., Mira, M. T. & Schurr, E. (2023). Allele-dependent interaction of LRRK2 and NOD2 in leprosy. PLoS pathogens, vol. 19, p. e1011260.
- Mendonca, L. E., Pernet, E., Khan, N., Sanz, J., Kaufmann, E., Downey, J., Grant, A., Orlova, M., Schurr, E., Krawczyk, C., Jones, R. G., Barreiro, L. B. & Divangahi, M. (2022). Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection. Frontiers in immunology, vol. 13, p. 1044592.
- Butler-Laporte, G., Gonzalez-Kozlova, E., Su, C.-Y., Zhou, S., Nakanishi, T., Brunet-Ratnasingham, E., Morrison, D., Laurent, L., Aflalo, J., Aflalo, M., Henry, D., Chen, Y., Carrasco-Zanini, J., Farjoun, Y., Pietzner, M., Kimchi, N., Afrasiabi, Z., Rezk, N., Bouab, M., Petitjean, L., Guzman, C., Xue, X., Tselios, C., Vulesevic, B., Adeleye, O., Abdullah, T., Almamlouk, N., Moussa, Y., DeLuca, C., Duggan, N., Schurr, E., Brassard, N., Durand, M., Del Valle, D. M., Thompson, R., Cedillo, M. A., Schadt, E., Nie, K., Simons, N. W., Mouskas, K., Zaki, N., Patel, M., Xie, H., Harris, J., Marvin, R., Cheng, E., Tuballes, K., Argueta, K., Scott, I., Mount Sinai COVID-19 Biobank Team, Greenwood, C. M. T., Paterson, C., Hinterberg, M., Langenberg, C., Forgetta, V., Mooser, V., Marron, T., Beckmann, N. D., Kenigsberg, E., Charney, A. W., Kim-Schulze, S., Merad, M., Kaufmann, D. E., Gnjatic, S. & Richards, J. B. (2022). Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals. Clinical proteomics, vol. 19, p. 40.
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