Information sur le laboratoire
Erwin Schurr (Ph.D.)
Scientifique séniorCentre de biologie translationnelle
Département de génétique humaine (McGill)
Profil de recherche
Mots-clés
Tuberculose • lèpre • traits complexes • transcriptomique • biologie des systèmesIntérêts de recherche
Ma recherche porte sur l'identification et l'évaluation de facteurs génétiques hôtes chez les cas de tuberculose et de lèpre. Nous travaillons sur ces maladies avec des groupes partenaires dans des pays endémiques et nous appliquons des concepts modernes de génétique, de génomique et de biologie des systèmes à nos analyse.Membre de l'équipe
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Dernières publications
- Fava, V. M., Dallmann-Sauer, M., Orlova, M., Correa-Macedo, W., Olivenstein, R., Costiniuk, C. T., Routy, J.-P., Barreiro, L. B. & Schurr, E. (2026). Continuous antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages. Frontiers in immunology, vol. 17, p. 1805936.
- Dallmann-Sauer, M., Xu, Y. Z., Correa-Macedo, W., Orlova, M. & Schurr, E. (2026). Tissue-specific transcriptional epistasis between Prkn and Lrrk2 during mycobacterial infection. Mammalian genome : official journal of the International Mammalian Genome Society, vol. 37.
- Tulu, B., Brehm, T. T., van Crevel, R., Dallenga, T., DiNardo, A. R., Dheda, K., Eggeling, J., Enbiale, W., Gröschel, M. I., Hao, J., Kumar, V., van Laarhoven, A., Londt, R., Prosser, G., Randall, P., Reiling, N., Rybniker, J., Schaible, U. E., Schurr, E., Suarez, I., Theobald, S. J., Wilkinson, R. J. & Lange, C. (2026). Host- and pathogen-related determinants of pulmonary versus extrapulmonary tuberculosis. European respiratory review : an official journal of the European Respiratory Society, vol. 35.
- Fava, V. M., Perico, J., Orlova, M., Dallmann-Sauer, M., Xu, Y. Z., Thuc, N. V., Thai, V. H., Belone, A. F., Latini, A. C. P. & Schurr, E. (2025). Bridging pleiotropic mechanisms in leprosy type-1 reactions and neurodegenerative diseases. Scientific reports, vol. 15, p. 45036.
- Conil, C., Bohlen, J., Kroon, E. E., Jean-Juste, M. A., Manry, J., Chaldebas, M., Bean, J. M., Walsh, K. F., Dallmann-Sauer, M., Rotival, M., Seeleuthner, Y., Marchal, A., Mourelatos, H., Fava, V. M., Zhang, P., Kerner, G., Skhoun, H., Abid, A., El Ouazzani, H., Rafik, A., Bousfiha, A. A., El Baghdadi, J., Wilkinson, R. J., Boisson-Dupuis, S., Fitzgerald, D. W., Pape, J. W., Möller, M., Hoal, E. G., Casanova, J.-L., Abel, L., Schurr, E. & Cobat, A. (2025). A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure. Genome medicine, vol. 17, p. 121.
- de Oliveira Mackert, C. C., Lázaro, F. P., Olandowski, M., D'Espindula, H. R. S., Dos Santos, A. M., Sartori, P. V. U., de Andrade Rodrigues, R. S., Cambri, G., Xavier, M. B., Schurr, E., Alcaïs, A. & Mira, M. T. (2025). Insights into leprosy epidemiology from an isolated population located in the Brazilian Amazon. Scientific reports, vol. 15, p. 6103.
- Dallmann-Sauer, M., Fava, V. M., Malherbe, S. T., MacDonald, C. E., Orlova, M., Kroon, E. E., Cobat, A., Boisson-Dupuis, S., Hoal, E. G., Abel, L., Möller, M., Casanova, J.-L., Walzl, G., Du Plessis, N. & Schurr, E. (2025). Mycobacterium tuberculosis resisters despite HIV exhibit activated T cells and macrophages in their pulmonary alveoli. The Journal of clinical investigation, vol. 135.
- Brehm, T. T., Köhler, N., Grobbel, H.-P., Welling, J., Mandalakas, A. M., Fava, V., Schurr, E. & Lange, C. (2025). High risk of drug-resistant tuberculosis in IGRA-negative contacts: should preventive treatment be considered?. Infection, vol. 53, p. 1501-1506.
- Correa-Macedo, W., Dallmann-Sauer, M., Orlova, M., Manry, J., Fava, V. M., Huong, N. T., Ba, N. N., Van Thuc, N., Thai, V. H. & Schurr, E. (2024). Transcriptome immune-regulatory differences between leprosy patients and type 1 reaction patients, before onset of symptoms. PLoS neglected tropical diseases, vol. 18, p. e0011866.
- Moodley, S., Kroon, E., Naidoo, C. C., Nyawo, G. R., Wu, B. G., Naidoo, S., Chiyaka, T. L., Tshivhula, H., Singh, S., Li, Y., Warren, R. M., Hoal, E. G., Schurr, E., Clemente, J. C., Segal, L. N., Möller, M. & Theron, G. (2024). Latent Tuberculosis Infection Is Associated with an Enrichment of Short-Chain Fatty Acid-Producing Bacteria in the Stool of Women Living with HIV. Microorganisms, vol. 12.
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