Information sur le laboratoire
Jean-Pierre Routy (M.D.)
Scientifique séniorCentre de biologie translationnelle
Département de médecine (McGill)
Profil de recherche
Mots-clés
VIH • Infections virales chroniques • CMV • HHV8 • Réservoirs du VIH • IntestinIntérêts de recherche
Mes recherches portent sur la pathogenèse du virus de l'immunodéficience humaine (VIH), dans le but de trouver un traitement contre cette maladie. L'amélioration des connaissances sur la tolérance immunitaire dans le cancer et l'immunométabolisme sera essentielle à l'élaboration d'une stratégie visant à vaincre les cancers et les maladies auto-immunes.Membre de l'équipe
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Dernières publications
- Ghahari, N., Shegefti, S., Alaei, M., Amara, A., Telittchenko, R., Isnard, S., Routy, J.-P., Olagnier, D. & van Grevenynghe, J. (2024). HSP60 controls mitochondrial ATP generation for optimal virus-specific IL-21-producing CD4 and cytotoxic CD8 memory T cell responses. Communications biology, vol. 7, p. 1688.
- Bitektine, E., Hagh-Daoust, H., Michel, R. P., Isnard, S. & Routy, J.-P. (2024). The Value of a Pet Scan in Selecting the Best Lymph Node to Biopsy, and Confirming the Diagnosis of Idiopathic Multicentric Castleman Disease with HLH And EBV Viremia in a Previously Healthy Adult. European journal of case reports in internal medicine, vol. 11, p. 004908.
- Xiong, Y., Xiang, D., Zhou, X., Huang, Y., Routy, J.-P. & Zhu, B. (2024). Application of metagenomic next-generation sequencing with brain tissue biopsy for diagnosing intracranial lesions in people with HIV. Precision clinical medicine, vol. 7, p. pbae029.
- Magombedze, G., Vendrame, E., SenGupta, D., Geleziunas, R., Little, S., Smith, D., Walker, B., Routy, J.-P., Hecht, F. M., Chun, T.-W., Sneller, M., Li, J. Z., Deeks, S. G. & Peluso, M. J. (2024). Early Viral Dynamics Predict HIV Post-Treatment Control After Analytic Treatment Interruption. The Journal of infectious diseases.
- Yero, A., Shi, T., Clain, J. A., Zghidi-Abouzid, O., Racine, G., Costiniuk, C. T., Routy, J.-P., Estaquier, J. & Jenabian, M.-A. (2024). Double-Negative T-Cells during Acute Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections and Following Early Antiretroviral Therapy Initiation. Viruses, vol. 16.
- Kabakibo, T. S., Arnold, E., Padhan, K., Lemieux, A., Ortega-Delgado, G. G., Routy, J.-P., Shoukry, N., Dubé, M. & Kaufmann, D. E. (2024). Artificial antigen-presenting cell system reveals CD28's role in modulating T cell functions during human immunodeficiency virus infection. iScience, vol. 27, p. 110947.
- Fert, A., Richard, J., Raymond Marchand, L., Planas, D., Routy, J.-P., Chomont, N., Finzi, A. & Ancuta, P. (2024). Metformin facilitates viral reservoir reactivation and their recognition by anti-HIV-1 envelope antibodies. iScience, vol. 27, p. 110670.
- Wu, L., Zheng, Z., Xun, J., Liu, L., Wang, J., Zhang, X., Shao, Y., Shen, Y., Zhang, R., Zhang, M., Sun, M., Qi, T., Wang, Z., Xu, S., Song, W., Tang, Y., Zhao, B., Song, Z., Routy, J.-P., Lu, H. & Chen, J. (2024). Anti-PD-L1 antibody ASC22 in combination with a histone deacetylase inhibitor chidamide as a "shock and kill" strategy for ART-free virological control: a phase II single-arm study. Signal transduction and targeted therapy, vol. 9, p. 231.
- Brenner, B. G., Ibanescu, R.-I., Oliveira, M., Margaillan, G., Lebouché, B., Thomas, R., Baril, J. G., Lorgeoux, R.-P., Roger, M., Routy, J.-P. & (2024). Phylogenetic Network Analyses Reveal the Influence of Transmission Clustering on the Spread of HIV Drug Resistance in Quebec from 2002 to 2022. Viruses, vol. 16.
- Yero, A., Goulet, J.-P., Shi, T., Costiniuk, C. T., Routy, J.-P., Tremblay, C., Mboumba Bouassa, R.-S., Alexandrova, Y., Pagliuzza, A., Chomont, N., Ancuta, P. & Jenabian, M.-A. (2024). Altered memory CCR6+ Th17-polarised T-cell function and biology in people with HIV under successful antiretroviral therapy and HIV elite controllers. EBioMedicine, vol. 107, p. 105274.
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