Lab Information

Marie-Josée Brouillette (MD)

Centre for Outcomes Research and Evaluation
Department of Psychiatry (McGill)

Research Profile

 Fundamental: 0%
 Clinical: 50%
 Epidemiology: 50%
 Evaluation: 0%
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Cognition in HIV • depression • rasch analysis

Research Interests

My research focuses on the psychiatric care of patients infected with HIV and those undergoing treatment for hepatitis C. These studies are concerned with regulation of cognition and mood. My main study in the area of HIV involves characterizing 900 HIV+ individuals across Canada who will be followed for 2.5 years to elucidate factors that contribute to the development of cognitive decline, with interventional trials being conducted in selected subgroups of individuals. Other projects include (1) documenting changes in cognition in HIV+ individuals at risk of cognitive decline over 1 year; (2) improving cognition in HIV+ individuals through a personalized change in antiretroviral medication informed by analysis of cerebrospinal fluid; and (3) developing a computerized tool that can measure cognitive ability in a clinical setting. All these studies involve interdisciplinary collaborations (neurology, neuropsychology, epidemiology, HIV clinicians and community groups) and aim to develop innovative solutions that can be applied in the clinic.

Team Members

Name Position

Latest Publications

  1. Castaneda, G., Fernandez Cruz, A. L., Sefranek, M., Yau, Y. H. C., Brouillette, M.-J., Mayo, N. E. & Fellows, L. K. (2022). Does effort-cost decision-making relate to real-world motivation in people living with HIV?. Journal of clinical and experimental neuropsychology, p. 1-12.
  2. Ramirez Garcia, M. P., Leclerc-Loiselle, J., Côté, J., Brouillette, M.-J. & Thomas, R. (2022). The process of learning the autogenic training relaxation technique and its benefits on the wellness of people living with HIV. BMC complementary medicine and therapies, vol. 22, p. 86.
  3. Milan, R., LeLorier, J., Brouillette, M.-J., Holbrook, A., Litvinov, I. V. & Rahme, E. (2022). Sex Differences in the Patterns of Systemic Agent use Among Patients With Psoriasis: A Retrospective Cohort Study in Quebec, Canada. Frontiers in pharmacology, vol. 13, p. 810309.
  4. Inceer, M., Brouillette, M.-J., Fellows, L. K., Morais, J. A., Harris, M., Smaill, F., Smith, G., Thomas, R. & Mayo, N. E. (2022). Factors partitioning physical frailty in people aging with HIV: A classification and regression tree approach. HIV medicine.
  5. Koski, L., Brouillette, M.-J., Mayo, N. E., Scott, S. C., Fellows, L. K. & Sookman, D. (2021). A Short-term Psychological Intervention for People Living with HIV During the First Wave of COVID-19. International journal of cognitive therapy, p. 1-21.
  6. Brouillette, M.-J., Koski, L., Scott, S., Austin-Keiller, A., Fellows, L. K. & Mayo, N. E. (2022). Factors influencing psychological distress during the COVID-19 pandemic in people aging with HIV. AIDS research and human retroviruses, vol. 38, p. 421-430.
  7. Mayo, N. E., Brouillette, M.-J., Nadeau, L., Dendukuri, N., Harris, M., Smaill, F., Smith, G., Thomas, R., Fellows, L. K. & Investigators from the Positive Brain Health Now Study (2022). A longitudinal view of successful aging with HIV: role of resilience and environmental factors. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, vol. 31, p. 1135-1145.
  8. Quigley, A., Brouillette, M.-J., Fellows, L. K. & Mayo, N. (2021). Action for better brain health among people living with HIV: protocol for a randomized controlled trial. BMC infectious diseases, vol. 21, p. 843.
  9. Milan, R., LeLorier, J., Brouillette, M.-J., Holbrook, A., Litvinov, I. V. & Rahme, E. (2021). Sex differences in factors associated with switch between systemic agents among individuals with psoriasis: A retrospective cohort study in Quebec, Canada. JAAD international, vol. 4, p. 79-83.
  10. Fernandez Cruz, A. L., Chen, C.-M., Sanford, R., Collins, D. L., Brouillette, M.-J., Mayo, N. E. & Fellows, L. K. (2021). Multimodal neuroimaging markers of variation in cognitive ability in older HIV+ men. PloS one, vol. 16, p. e0243670.
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