Prof. Lynn is Professor of Systems Immunology at the South Australian Health and Medical Research Institute and Flinders University College of Medicine and Public Health and is also Scientific Director of the SA Genomics Centre (SAGC), an Australian national genomics facility. He leads a research program in systems immunology investigating how microbes (pathogenic and commensal) and vaccines influence our immune system in a range of contexts.

His work in the microbiome field has uncovered key roles for the microbiota in regulating vaccine responses (Cell Host Microbe 2018; Nature Reviews Immunology 2022; Gut 2024; Nature 2025), mammalian longevity (Cell Reports, 2021) and cancer immunotherapies (Cell Reports Medicine 2021, Nature Reviews Immunology 2024). His current clinical studies include the Antibiotics and Vaccine Immune Responses Study (AVIRS; NCT06148025), which is employing highly innovative human experimental challenge models to conclusively demonstrate whether disruption of the gut microbiota, prior to immunisation, leads to impaired pathogen-specific (BCG re-challenge) and/or non-specific immune responses (Yellow Fever vaccine strain challenge).

Building on his team’s recent work (Nature, 2025), Prof. Lynn has also established a randomised controlled trial to assess whether immune responses to vaccination are improved in antibiotic-treated infants randomised to a probiotic intervention (https://clinicaltrials.gov/study/NCT07189390). In 2027, Prof. Lynn will take up a new position at the McGill University Department of Microbiology and Immunology and at RI-MUHC, as Professor of Systems Immunology.