Lab Information

Marie-Josée Brouillette (MD)

Centre for Outcomes Research and Evaluation
Department of Psychiatry (McGill)

Research Profile

 Fundamental: 0%
 Clinical: 50%
 Epidemiology: 50%
 Evaluation: 0%
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Cognition in HIV • depression • rasch analysis

Research Interests

My research focuses on the psychiatric care of patients infected with HIV and those undergoing treatment for hepatitis C. These studies are concerned with regulation of cognition and mood. My main study in the area of HIV involves characterizing 900 HIV+ individuals across Canada who will be followed for 2.5 years to elucidate factors that contribute to the development of cognitive decline, with interventional trials being conducted in selected subgroups of individuals. Other projects include (1) documenting changes in cognition in HIV+ individuals at risk of cognitive decline over 1 year; (2) improving cognition in HIV+ individuals through a personalized change in antiretroviral medication informed by analysis of cerebrospinal fluid; and (3) developing a computerized tool that can measure cognitive ability in a clinical setting. All these studies involve interdisciplinary collaborations (neurology, neuropsychology, epidemiology, HIV clinicians and community groups) and aim to develop innovative solutions that can be applied in the clinic.

Team Members

Name Position

Latest Publications

  1. Michael, H. U., Enechukwu, O., Brouillette, M.-J., Tamblyn, R., Fellows, L. K. & Mayo, N. E. (2023). The Prognostic Utility of Anticholinergic Burden Scales: An Integrative Review and Gap Analysis. Drugs & aging, vol. 40, p. 763-783.
  2. Humayun, M. M., Brouillette, M.-J., Fellows, L. K. & Mayo, N. E. (2023). The Patient Generated Index (PGI) as an early-warning system for predicting brain health challenges: a prospective cohort study for people living with Human Immunodeficiency Virus (HIV). Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation.
  3. Isnard, S., Royston, L., Scott, S. C., Mabanga, T., Lin, J., Fombuena, B., Bu, S., Berini, C. A., Goldberg, M. S., Finkelman, M., Brouillette, M.-J., Fellows, L. K., Mayo, N. E. & Routy, J.-P. (2023). Translocation of bacterial LPS is associated with self-reported cognitive abilities in men living with HIV receiving antiretroviral therapy. AIDS research and therapy, vol. 20, p. 30.
  4. Rivest, J., Rouly, G., Brouillette, M.-J., Nguyen, O. & Desbeaumes Jodoin, V. (2023). Improving Palliative Care and Medical Assistance in Dying Practice in Canada: How Patients-Partners Could Contribute to Continuing Medical Education. Palliative medicine reports, vol. 4, p. 116-119.
  5. Austin-Keiller, A., Park, M., Yang, S., Mayo, N. E., Fellows, L. K. & Brouillette, M.-J. (2023). "Alone, there is nobody": A qualitative study of the lived experience of loneliness in older men living with HIV. PloS one, vol. 18, p. e0277399.
  6. Mukerji, S. S., Petersen, K. J., Pohl, K. M., Dastgheyb, R. M., Fox, H. S., Bilder, R. M., Brouillette, M.-J., Gross, A. L., Scott-Sheldon, L. A. J., Paul, R. H. & Gabuzda, D. (2023). Machine Learning Approaches to Understand Cognitive Phenotypes in People With HIV. The Journal of infectious diseases, vol. 227, p. S48-S57.
  7. Mozafarinia, M., Mate, K. K. V., Brouillette, M.-J., Fellows, L. K., Knäuper, B. & Mayo, N. E. (2023). An umbrella review of the literature on the effectiveness of goal setting interventions in improving health outcomes in chronic conditions. Disability and rehabilitation, p. 1-11.
  8. Mate, K. K. V., Lebouché, B., Brouillette, M.-J., Fellows, L. K. & Mayo, N. E. (2022). Development of a Prototype for a Bilingual Patient-Reported Outcome Measure of the Important Health Aspects of Quality of Life in People Living with HIV: The Preference Based HIV Index (PB-HIV). Journal of personalized medicine, vol. 12.
  9. Mboumba Bouassa, R.-S., Needham, J., Nohynek, D., Singer, J., Lee, T., Bobeuf, F., Samarani, S., Del Balso, L., Paisible, N., Vertzagias, C., Sebastiani, G., Margolese, S., Mandarino, E., Klein, M., Lebouché, B., Cox, J., Brouillette, M.-J., Routy, J.-P., Szabo, J., Thomas, R., Huchet, E., Vigano, A., Jenabian, M.-A. & Costiniuk, C. T. (2022). Safety and Tolerability of Oral Cannabinoids in People Living with HIV on Long-Term ART: A Randomized, Open-Label, Interventional Pilot Clinical Trial (CTNPT 028). Biomedicines, vol. 10.
  10. Ramirez Garcia, M. P., Leclerc-Loiselle, J., Côté, J., Brouillette, M.-J. & Thomas, R. (2023). Effect of autogenic training on quality of life and symptoms in people living with HIV: A mixed method randomized controlled trial. Complementary therapies in clinical practice, vol. 50, p. 101716.
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