Lab Information
Marina Klein (MD/MSc)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
http://www.cocostudy.ca/
Keywords
HIV • Hepatitis C • clinical trials • epidemiology • antiretrovirals • prospective cohortResearch Interests
My research program builds on years of multidisciplinary work leading one of the largest cohorts focused on HIV and hepatitis C virus (HCV) co-infection in the world. As Canada Research Chair in Clinical and Epidemiologic Studies of Chronic Viral Infections in Vulnerable Populations, I am documenting the impact of new HCV therapies on health outcomes, designing and testing tailored approaches to increase access to diagnosis and treatment, building capacity for research with Indigenous communities, and using evidence generated to advocate for policy change. My goal is to pave the way to eliminating HCV and other chronic viral infections in Canada and globally. To this end, I am leading an ambitious project called Montreal Sans Hep C, which aims to make Montreal the first City in North America to eliminate HCV.Team Members
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Latest Publications
- Gobran, S. T., Ortiz, A. E., Khedr, O., Dion, J., Raymond Marchand, L., Dias, J., Cattin, A., Bruneau, J., Chomont, N., Klein, M. B., Ancuta, P. & Shoukry, N. H. (2026). HCV-specific CD4+ T-cells are susceptible to HIV-1 and contribute to viral persistence during antiretroviral therapy. EBioMedicine, vol. 130, p. 106365.
- Li, J., Haj-Husein, I., Ghafari, N., Khorraminezhad, L., Iskandar, M., Zaouter, C., Klein, M., Sleno, L., Patten, S. A. & Kubow, S. (2026). Untargeted metabolomics and proteomics reveals cocoa-mediated mitigation of valproic acid-induced dysregulation in a zebrafish model of autism: pilot study. Metabolomics : Official journal of the Metabolomic Society, vol. 22.
- Nicolls, S., McClymont, E., Lee, M., Coutlée, F., Trottier, S., Smaill, F., Loutfy, M., Yudin, M. H., Klein, M. B., Harris, M., Stone, S., Martinez-Cajas, J., Walmsley, S., Money, D. & HPV in HIV Study Team (2026). Incidence and Prevalence of Human Papillomavirus Infection to Predict Outcomes from HPV-Based Cervical Cancer Screening in Women and People with a Cervix Living with HIV. Journal of acquired immune deficiency syndromes (1999).
- Cinque, F., Nudo, M., Saeed, S., Lim, J., Kablawi, D., Mariano, G., Lupu, A., Elgretli, W., Moodie, E. E. M., Price, C., Monteith, K., Cooper, C., Walmsley, S., Kronfli, N., Cox, J., Costiniuk, C., De Pokomandy, A., Routy, J.-P., Klein, M. B., Lebouche, B. & Sebastiani, G. (2026). Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Impaired Health-Related Quality of Life in People With HIV. Gastro hep advances, vol. 5, p. 100966.
- El Sheikh, M. Z., Panagiotoglou, D., Greenaway, C. & Klein, M. B. (2026). Effect of hepatitis C virus treatment engagement on the skin and soft tissue infections healthcare burden among people who inject drugs in Quebec, Canada: a population-based interrupted time series study. The International journal on drug policy, vol. 154, p. 105335.
- Boateng, N. A., Balasubramaniam, V. M., Pascall, M. A. & Klein, M. S. (2026). Nutrient-induced germination of Bacillus subtilis spores exhibiting shared metabolic profiles in both TSB and AGFK media. Metabolomics : Official journal of the Metabolomic Society, vol. 22.
- Walmsley, S. L., Lovblom, L. E., Boyachuk, B., Cooper, C., Martel-Laferrière, V., Loutfy, M., Vachon, M.-L., Haider, S., Aldebes, P., Colwill, K., Gingras, A. C., Qi, F. & Klein, M. B. (2026). SARS-CoV-2 Infection and COVID-19 Vaccine Antibody Responses in Two Canadian Cohorts of Persons Living with HIV. Antibodies (Basel, Switzerland), vol. 15.
- Young, J., Lawler, P. R., Moodie, E. E. M., Bucher, H. C. & Klein, M. B. (2026). It's about time: The association between abacavir and cardiovascular disease. Antiviral therapy, vol. 31, p. 13596535261438178.
- Young, J., Wang, S., Knight, M., Cardinal, C. L., Cooper, C. L., Cox, J., Hull, M., Martel-Laferriere, V., Sutherland, D. J., Walmsley, S., Wong, A., Klein, M. B. & Canadian Coinfection Cohort (2026). The risk of HIV and HCV transmission in Canadians living with coinfection before, during, and after the COVID pandemic: A prospective cohort study. Canadian journal of public health = Revue canadienne de sante publique.
- Chalouni, M., Torgersen, J., Rentsch, C. T., Van Santen, D. K., Jarrin, I., Klein, M. B., Young, J., Gill, M. J., Epstein, R. L., Linas, B., Zangerle, R., Surial, B., Nemeth, J., Touloumi, G., Papadopoulos, A., Wittkop, L., Van Der Valk, M., Boyd, A., Monforte, A. D., Puoti, M., Logan, R. W., Rein, S. M., Miro, J. M., Berenguer, J., Hernán, M. A. & Lodi, S. (2026). Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for Hepatitis C virus in people with HIV. AIDS (London, England), vol. 40, p. 1073-1081.
See also
