Lab Information
Donald Vinh (MD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Primary (genetic) immunodeficiencies • molecular genetics • translational research • immunity • infectionsResearch Interests
My research focuses on identifying how genetic defects of immunity predispose patients to infectious diseases. A fundamental enigma in the field of infectious diseases is the variability in clinical outcomes between individuals exposed to the same microbial environment. For a given microbe, what distinguishes those who are “well” or “mildly symptomatic” from those who develop “life-threatening disease”? Accumulating evidence demonstrates that mutations in critical genes can cause a variety of immunodeficiencies, resulting in human susceptibility to specific infectious diseases. My research program is distinguished by the unique ability to bring patients (and relevant family members) with unusual, severe or recalcitrant infections into the laboratory and meticulously study them, through state-of-the-art genomic and functional immunologic studies and model systems, to delineate fundamental principles of human immunobiology. In so doing, we aim to translate our findings into innovative therapies directly relevant for patients, and to discover novel diseases of human immunity.Team Members
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Latest Publications
- Chen, G. S., Lee, T., Tsang, J. L. Y., Binnie, A., McCarthy, A., Cowan, J., Archambault, P., Lellouche, F., Turgeon, A. F., Yoon, J., Lamontagne, F., McGeer, A., Douglas, J., Daley, P., Fowler, R., Maslove, D. M., Winston, B. W., Lee, T. C., Tran, K. C., Cheng, M. P., Vinh, D. C., Boyd, J. H., Walley, K. R., Singer, J., Marshall, J. C. & Russell, J. A. (2025). Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia. Critical care explorations, vol. 7, p. e1262.
- Landekic, M., Angers, I., Li, Y., Guiot, M.-C., Déry, M.-A., Beauchamp, A., Roussel, L., Boisvert, A., Zhou, W. B., Gavino, C., Luo, J., Bernier, S., Kazimerczak-Brunet, M., Sun, Y., Snarr, B., Lionakis, M. S., Wheeler, R. T., King, I. L., Qureshi, S., Divangahi, M. & Vinh, D. C. (2025). A CARD9-deficiency mouse model recapitulates human chronic CNS candidiasis, identifying defective monocytic-cell responses in immunopathogenesis. JCI insight.
- Vinh, D. C. (2025). Host-directed immunotherapy for viral infections. Current opinion in infectious diseases.
- Westfall, S., Gentile, M. E., Olsen, T. M., Karo-Atar, D., Bogza, A., Röstel, F., Pardy, R. D., Mandato, G., Fontes, G., Herbert, D., Melichar, H. J., Abadie, V., Richer, M. J., Vinh, D. C., Koenig, J. F. E., Harrison, O. J., Divangahi, M., Weis, S., Gregorieff, A. & King, I. L. (2025). A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection. Cell.
- Vinh, D. C. (2025). Human immunity to fungal infections. The Journal of experimental medicine, vol. 222.
- Roussel, L., Bernier, S., Evaristo, G., Perez, A., Zaabat, S., Pace, R., Sun, Y., Angers, I., Storring, J. & Vinh, D. C. (2025). Leaky Artemis Deficiency and EBV-Related Lymphoproliferative Disease: A Novel Case and Review of the Literature. EJHaem, vol. 6, p. e270026.
- Rubin, T., Bernier, S., Hoon Lim, L. S., Salman, M. S., Leung, E., Mhanni, A., Marles, S., Greenberg, C., Perez, A., Sun, Y., Angers, I., Vinh, D. C. & Roussel, L. (2025). Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome. Frontiers in immunology, vol. 16, p. 1557632.
- Cruz-Santiago, D., Meng, X., Canac-Marquis, M., Sengupta, A., Brassard, J.-P., Pavey, E., Girouard, H., Vinh, D. C. & Gouin, J.-P. (2025). Neuropsychiatric Symptoms and Psychotropic Medication Use Following SARS-Cov-2 Infection Among Elderly Residents in Long-Term Care Facilities. Canadian geriatrics journal : CGJ, vol. 28, p. 67-72.
- Cornely, O. A., Sprute, R., Bassetti, M., Chen, S.-C., Groll, A. H., Kurzai, O., Lass-Flörl, C., Ostrosky-Zeichner, L., Rautemaa-Richardson, R., Revathi, G., Santolaya, M. E., White, P. L., Alastruey-Izquierdo, A., Arendrup, M. C., Baddley, J., Barac, A., Ben-Ami, R., Brink, A. J., Grothe, J. H., Guinea, J., Hagen, F., Hochhegger, B., Hoenigl, M., Husain, S., Jabeen, K., Jensen, H. E., Kanj, S. S., Koehler, P., Lehrnbecher, T., Lewis, R. E., Meis, J. F., Nguyen, M. H., Pana, Z. D., Rath, P.-M., Reinhold, I., Seidel, D., Takazono, T., Vinh, D. C., Zhang, S. X., Afeltra, J., Al-Hatmi, A. M. S., Arastehfar, A., Arikan-Akdagli, S., Bongomin, F., Carlesse, F., Chayakulkeeree, M., Chai, L. Y. A., Chamani-Tabriz, L., Chiller, T., Chowdhary, A., Clancy, C. J., Colombo, A. L., Cortegiani, A., Corzo Leon, D. E., Drgona, L., Dudakova, A., Farooqi, J., Gago, S., Ilkit, M., Jenks, J. D., Klimko, N., Krause, R., Kumar, A., Lagrou, K., Lionakis, M. S., Lmimouni, B. E., Mansour, M. K., Meletiadis, J., Mellinghoff, S. C., Mer, M., Mikulska, M., Montravers, P., Neoh, C. F., Ozenci, V., Pagano, L., Pappas, P., Patterson, T. F., Puerta-Alcalde, P., Rahimli, L., Rahn, S., Roilides, E., Rotstein, C., Ruegamer, T., Sabino, R., Salmanton-García, J., Schwartz, I. S., Segal, E., Sidharthan, N., Singhal, T., Sinko, J., Soman, R., Spec, A., Steinmann, J., Stemler, J., Taj-Aldeen, S. J., Talento, A. F., Thompson, G. R., Toebben, C., Villanueva-Lozano, H., Wahyuningsih, R., Weinbergerová, B., Wiederhold, N., Willinger, B., Woo, P. C. Y. & Zhu, L.-P. (2025). Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM. The Lancet. Infectious diseases, vol. 25, p. e280-e293.
- Unninayar, D., Falcone, E. L., Chapdelaine, H., Vinh, D. C., Top, K. A., Derfalvi, B., Issekutz, T. B., Decaluwe, H., Pham-Huy, A., Upton, J., Betschel, S. D., Rubin, T., Suresh, S., Wright, N. A. M., Murguía-Favela, L., Kalashnikova, T., Barrett, L., Oldford, S., Langlois, M.-A., Arnold, C., Sadarangani, M., Zhang, T., Ramsay, T., Yazji, D. & Cowan, J. (2024). Humoral and cell-mediated immune responses to COVID-19 vaccines up to 6 months post three-dose primary series in adults with inborn errors of immunity and their breakthrough infections. Frontiers in immunology, vol. 15, p. 1501908.
See also
