Lab Information
Brian Ward (MD)
Senior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Vaccines • respiratory viruses • international health • parasitology • diagnosticsResearch Interests
My research focuses on: the development and evaluation of novel virus-like particle vaccines (eg: influenza, measles) in both young and elderly subjects, international health issues with a particular focus on factors that influence HIV transmission, virus-nutritional interactions, and the development of new diagnostic tests for parasitic diseases. My laboratory sits at the junction between infectious diseases clinic and the basic science laboratory. Projects can start at either end of this spectrum and move from 'bed to the bench-top' or from 'bench-top to the bed'. Most of the basic work is carried out in Montreal with satellite facilities in Peru and Zimbabwe. Human vaccine studies are conducted at the MUHC Vaccine Study Centre in Pierrefonds, QC.Team Members
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Latest Publications
- Yegorov, S., Brewer, A., Cyr, L., Ward, B. J., Pullenayegum, E., Miller, M. S. & Loeb, M. (2024). Hemagglutination-Inhibition Antibodies and Protection against Influenza Elicited by Inactivated and Live Attenuated Vaccines in Children. The Journal of infectious diseases.
- Wright, J., Crowcroft, N., McLachlan, E., Perez-Iratxeta, C., Joh, E., Osman, S., Hatchette, T., Deeks, S. L., Wilson, S. E., Hughes, S. L., Halperin, S. A., Buchan, S. A., Ward, B. J., Gubbay, J., Brisson, M., Serhir, B., Severini, A. & Bolotin, S. (2024). Population immunity to varicella in Canada: A Canadian Immunization Research Network (CIRN) study. PloS one, vol. 19, p. e0309154.
- Grigoryan, L., Feng, Y., Bellusci, L., Lai, L., Wali, B., Ellis, M., Yuan, M., Arunachalam, P. S., Hu, M., Kowli, S., Gupta, S., Maysel-Auslender, S., Maecker, H. T., Samaha, H., Rouphael, N., Wilson, I. A., Moreno, A. C., Suthar, M. S., Khurana, S., Pillet, S., Charland, N., Ward, B. J. & Pulendran, B. (2024). AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans. Science immunology, vol. 9, p. eadi8039.
- Winter, K., Houle, S., Dozois, C. M. & Ward, B. J. (2024). Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge. Microbiology spectrum, vol. 12, p. e0310922.
- Bolotin, S., Osman, S., Halperin, S., Severini, A., Ward, B. J., Sadarangani, M., Hatchette, T., Pebody, R., Winter, A., De Melker, H., Wheeler, A. R., Brown, D., Tunis, M. & Crowcroft, N. (2023). Immunity of Canadians and risk of epidemics workshop - Conference report. Vaccine, vol. 41, p. 6775-6781.
- Shapiro, J. R., Andreani, G., Dubé, C., Berubé, M., Bussière, D., Couture, M.-M., Dargis, M., Hendin, H. E., Landry, N., Lavoie, P.-O., Pillet, S., Ward, B. J., D'Aoust, M.-A. & Trépanier, S. (2023). Development and characterization of a plant-derived norovirus-like particle vaccine. Vaccine, vol. 41, p. 6008-6016.
- Hanula, R., Bortolussi-Courval, É., Mendel, A., Ward, B. J., Lee, T. C. & McDonald, E. G. (2024). Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza: A Systematic Review and Meta-analysis. JAMA internal medicine, vol. 184, p. 18-27.
- Hassan, A. S., Houle, S., Labrie, L., Perera, D. J., Dozois, C. M., Ward, B. J. & Ndao, M. (2023). Salmonella Typhimurium expressing chromosomally integrated Schistosoma mansoni Cathepsin B protects against schistosomiasis in mice. NPJ vaccines, vol. 8, p. 27.
- Kaplonek, P., Cizmeci, D., Lee, J.-S., Shin, S. A., Fischinger, S., Gobeil, P., Pillet, S., Charland, N., Ward, B. J. & Alter, G. (2023). Robust induction of functional humoral response by a plant-derived Coronavirus-like particle vaccine candidate for COVID-19. NPJ vaccines, vol. 8, p. 13.
- Gobeil, P., Pillet, S., Boulay, I., Charland, N., Lorin, A., Cheng, M. P., Vinh, D. C., Boutet, P., Van Der Most, R., Roman, F., Ceregido, M. A., Landry, N., D'Aoust, M.-A. & Ward, B. J. (2022). Durability and cross-reactivity of immune responses induced by a plant-based virus-like particle vaccine for COVID-19. Nature communications, vol. 13, p. 6905.
See also
