Lab Information

Inés Colmegna (MD)

Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Immunology • arthritis • aging • stem cells

Research Interests

My research focuses on understanding the mechanisms underlying the development and perpetuation of the most common form of inflammatory polyarthritis: rheumatoid arthritis. Specifically, we study the impact of aging on human immune and stem cell function and how aging promotes the disruption of immune tolerance increasing the risk of developing autoimmune disorders.

Team Members

Name Position

Latest Publications

  1. Yu, J. C. Y., Zeng, Y., Zhao, K., Lu, T., Oros Klein, K., Colmegna, I., Lora, M., Bhatnagar, S. R., Leask, A., Greenwood, C. M. T. & Hudson, M. (2023). Novel insights into systemic sclerosis using a sensitive computational method to analyze whole-genome bisulfite sequencing data. Clinical epigenetics, vol. 15, p. 96.
  2. Colmegna, I. & Libman, M. (2023). The 2022 ACR vaccination guideline: a call-to-action. Nature reviews. Rheumatology, vol. 19, p. 263-264.
  3. Costiniuk, C. T., Singer, J., Needham, J., Yang, Y., Qian, H., Chambers, C., Burchell, A. N., Samji, H., Colmegna, I., Del Canto, S., Godin, G.-H., Habanyama, M., Hui, C., Kroch, A., Mandarino, E., Margolese, S., Martin, C., Owino, M., Mohammadi, T., Zhang, W., Pelaez, S., Kovacs, C., Benko, E., Vulesevic, B., Cooper, C. L. & Anis, A. H. (2023). Understanding COVID-19 Vaccine Confidence in People Living with HIV: A pan-Canadian Survey. AIDS and behavior, p. 1-13.
  4. Hazlewood, G. S., Colmegna, I., Hitchon, C., Fortin, P. R., Bernatsky, S., Clarke, A. E., Mosher, D., Wilson, T., Thomas, M., Barber, C. E. H., Harrison, M., Bansback, N., Proulx, L., Richards, D. P. & Kaplan, G. G. (2023). Preferences for COVID-19 Vaccination in People With Chronic Immune-Mediated Inflammatory Diseases. The Journal of rheumatology, vol. 50, p. 949-957.
  5. Mendel, A., Colmegna, I., Bourque, G., Rajda, E., Lee, T. C., Gálvez, J. H., Vinet, É. & Cheng, M. P. (2022). More than a 'Hundred Days War': Persistent SARS-CoV-2 infection in a patient with ANCA-associated vasculitis. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 7, p. 131-134.
  6. Colmegna, I. & Weinblatt, M. E. (2022). From Canadian Living Guidelines to Global Living Guidelines: A Post Pandemic Effort. The Journal of rheumatology, vol. 49, p. 1077-1078.
  7. Valerio, V., Rampakakis, E., Zanos, T. P., Levy, T. J., Shen, H. C., McDonald, E. G., Frenette, C., Bernatsky, S., Hudson, M., Ward, B. J. & Colmegna, I. (2022). High Frequency of COVID-19 Vaccine Hesitancy among Canadians Immunized for Influenza: A Cross-Sectional Survey. Vaccines, vol. 10.
  8. Lopez-Olivo, M. A., Valerio, V., Karpes Matusevich, A. R., Brizio, M., Kwok, M., Geng, Y., Suarez-Almazor, M. E. & Colmegna, I. (2022). Safety and Efficacy of Influenza Vaccination in Patients Receiving Immune Checkpoint Inhibitors. Systematic Review with Meta-Analysis. Vaccines, vol. 10.
  9. Psaroudis, R. T., Singh, U., Lora, M., Jeon, P., Boursiquot, A., Stochaj, U., Langlais, D. & Colmegna, I. (2022). CD26 is a senescence marker associated with reduced immunopotency of human adipose tissue-derived multipotent mesenchymal stromal cells. Stem cell research & therapy, vol. 13, p. 358.
  10. Ta, V., Schieir, O., Valois, M.-F., Colmegna, I., Hitchon, C., Bessette, L., Hazlewood, G., Thorne, C., Pope, J., Boire, G., Tin, D., Keystone, E. C., Bykerk, V. P. & Bartlett, S. J. (2022). Predictors of Influenza Vaccination in Early Rheumatoid Arthritis 2017-2021: Results From the Canadian Early Arthritis Cohort. ACR open rheumatology, vol. 4, p. 566-573.
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