Lab Information

Inés Colmegna (MD)

Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Immunology • arthritis • aging • stem cells

Research Interests

My research focuses on understanding the mechanisms underlying the development and perpetuation of the most common form of inflammatory polyarthritis: rheumatoid arthritis. Specifically, we study the impact of aging on human immune and stem cell function and how aging promotes the disruption of immune tolerance increasing the risk of developing autoimmune disorders.

Team Members

Name Position

Latest Publications

  1. Ta, V., Schieir, O., Valois, M.-F., Colmegna, I., Hitchon, C., Bessette, L., Hazlewood, G., Thorne, C., Pope, J., Boire, G., Tin, D., Keystone, E. C., Bykerk, V. P. & Bartlett, S. J. (2022). Predictors of Influenza Vaccination in Early Rheumatoid Arthritis 2017-2021: Results From the Canadian Early Arthritis Cohort. ACR open rheumatology.
  2. Labbé, S., Colmegna, I., Valerio, V., Boucher, V. G., Peláez, S., Dragomir, A. I., Laurin, C., Hazel, E. M., Bacon, S. L. & Lavoie, K. L. (2022). Training Physicians in Motivational Communication to Address Influenza Vaccine Hesitation: A Proof-of-Concept Study. Vaccines, vol. 10.
  3. Valerio, V., Hudson, M., Wang, M., Bernatsky, S., Hazel, E. M., Ward, B. & Colmegna, I. (2022). Influenza Vaccine Hesitancy and Its Determinants Among Rheumatology Patients. ACR open rheumatology, vol. 4, p. 352-362.
  4. de França, N. R., Ménard, H. A., Lora, M., Zhou, Z., Rauch, J., Hitchon, C., Andrade, L. E. C. & Colmegna, I. (2022). Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis. Arthritis research & therapy, vol. 24, p. 23.
  5. Zeng, Y., Zhao, K., Oros Klein, K., Shao, X., Fritzler, M. J., Hudson, M., Colmegna, I., Pastinen, T., Bernatsky, S. & Greenwood, C. M. T. (2021). Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals. Genes, vol. 12.
  6. Hitchon, C. A., Mody, G. M., Feldman, C. H., Lau, Y., Shi, S., Meltzer, M., Scuccimarri, R., Weinblatt, M. E. & Colmegna, I. (2021). Perceptions and Challenges Experienced by African Physicians When Prescribing Methotrexate for Rheumatic Disease: An Exploratory Study. ACR open rheumatology, vol. 3, p. 522-530.
  7. Colmegna, I., Valerio, V., Gosselin-Boucher, V., Lacoste, G., Labbe, S., Lavoie, K. L., Hazel, E., Ward, B., Hudson, M. & Peláez, S. (2021). Barriers and facilitators to influenza and pneumococcal vaccine hesitancy in rheumatoid arthritis: a qualitative study. Rheumatology (Oxford, England), vol. 60, p. 5257-5270.
  8. Hazlewood, G. S., Pardo, J. P., Barnabe, C., Schieir, O., Barber, C. E. H., Bernatsky, S., Colmegna, I., Hitchon, C., Loeb, M., Mertz, D., Proulx, L., Richards, D. P., Scuccimarri, R., Tugwell, P., Schünemann, H. J., Mirza, R. D., Zhou, A. L., Nikolic, R. P. A., Thomas, M., Chase, H., Ejaredar, M. & Nieuwlaat, R. (2021). Canadian Rheumatology Association Recommendation for the Use of COVID-19 Vaccination for Patients With Autoimmune Rheumatic Diseases. The Journal of rheumatology, vol. 48, p. 1330-1339.
  9. Hoa, S., Laaouad, L., Roberts, J., Ennis, D., Ye, C., Al Jumaily, K., Pope, J., Nevskaya, T., Saltman, A., Himmel, M., Rottapel, R., Ly, C., Colmegna, I., Fifi-Mah, A., Maltez, N., Tisseverasinghe, A., Hudson, M. & Jamal, S. (2021). Preexisting autoimmune disease and immune-related adverse events associated with anti-PD-1 cancer immunotherapy: a national case series from the Canadian Research Group of Rheumatology in Immuno-Oncology. Cancer immunology, immunotherapy : CII, vol. 70, p. 2197-2207.
  10. Cheng, A., Choi, D., Lora, M., Shum-Tim, D., Rak, J. & Colmegna, I. (2020). Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo. Stem cell research & therapy, vol. 11, p. 539.
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