Information sur le laboratoire
Giada Sebastiani (M.D.)
Scientifique séniorCentre de recherche évaluative en santé
Département de médecine (McGill)
Profil de recherche
Mots-clés
Stéatose hépatique • Biomarqueurs sériques hépatiques • Élastographie • VIH • Hépatite C • Hépatite BIntérêts de recherche
Mes recherches portent sur le dépistage de la fibrose hépatique et de la stéatose hépatique chez les populations à risque, notamment les patients séropositifs, les patients diabétiques et obèses, les femmes atteintes du syndrome des ovaires polykystiques et les patients atteints de maladies inflammatoires intestinales. Pour mener ces études, j'utilise des biomarqueurs sériques de la fibrose et un appareil non invasif, basé sur les ultrasons, appelé Fibroscan. Je suis également l'investigateur principal de plusieurs essais cliniques mondiaux portant sur des composés antifibrotiques dans la SHNA.Membre de l'équipe
| Nom | Poste |
|---|
Dernières publications
- Xu, X., Shi, Y., Tacke, F., Wai-Sun Wong, V., Li, W., Sebastiani, G., Newsome, P. N., Romero-Gomez, M., Pan, C., Castera, L., Chai, J., Kim, W., Valenti, L., Yilmaz, Y., Win, K. M., Xu, X., Ocama, P., Ghazinyan, H., Al Mahtab, M., Hamid, S., Lesmana, C. R. A., Romeo, S., Castellanos Fernandez, M. I., Yu, X., Luukkonen, P. K., Takahashi, H., Charatcharoenwitthaya, P., Boursier, J., Cua, I. H., Dao, H. V., Spearman, C. W., Bandara Dassanayake, S. U., Ayurzana, M., Aghayeva, G., Muthiah, M. D., Mendez-Sanchez, N., Stedman, C. A., Alswat, K., Sharara, A. I., Debzi, N., Leite, N. C., Alkhatry, M. S., van Kleef, L. A., Barakat, S., Al-Busafi, S. A., Agyei-Nkansah, A., Fouad, Y., Gracia-Sancho, J., Lupsor-Platon, M., Ryan, J. D., Chan, W.-K., Cortez-Pinto, H., Mandorfer, M., Duseja, A., Papatheodoridis, G., Francque, S. M., Byrne, C. D., Targher, G., George, J., Zheng, M.-H., Global Hepatology Training Consortium, Xu, X., Shi, Y., Tacke, F., Wai-Sun Wong, V., Li, W., Sebastiani, G., Newsome, P. N., Romero-Gomez, M., Pan, C., Castera, L., Chai, J., Kim, W., Valenti, L., Yilmaz, Y., Win, K. M., Xu, X., Ocama, P., Ghazinyan, H., Al Mahtab, M., Hamid, S., Lesmana, C. R. A., Romeo, S., Castellanos Fernandez, M. I., Yu, X., Luukkonen, P. K., Takahashi, H., Charatcharoenwitthaya, P., Boursier, J., Cua, I. H., Dao, H. V., Spearman, C. W., Bandara Dassanayake, S. U., Ayurzana, M., Aghayeva, G., Muthiah, M. D., Mendez-Sanchez, N., Stedman, C. A., Alswat, K., Sharara, A. I., Debzi, N., Leite, N. C., Alkhatry, M. S., van Kleef, L. A., Barakat, S., Al-Busafi, S. A., Agyei-Nkansah, A., Fouad, Y., Gracia-Sancho, J., Lupsor-Platon, M., Ryan, J. D., Chan, W.-K., Cortez-Pinto, H., Mandorfer, M., Duseja, A., Papatheodoridis, G., Francque, S. M., Byrne, C. D., Targher, G., George, J., Zheng, M.-H. & Global Hepatology Training Consortium (2026). Delphi survey to explore core curriculum for training the next-generation of hepatologists☆. JHEP reports : innovation in hepatology, p. 101942.
- Abow-Mohamed, I., Alabdulkarim, B., Zhao, X., Kablawi, D., Desgagné, E., Deschenes, M., Wong, P., Chen, T., Sebastiani, G., Rehany, B., Abu-Nada, M., Valenti, D., Bessissow, A. & Benmassaoud, A. (2026). Low muscle mass predicts liver-related outcomes in cirrhosis, independent of portal hypertension: A retrospective cohort study. Canadian liver journal, vol. 9, p. 243-253.
- Zhou, X.-D., Huang, D. Q., Sebastiani, G. & Zheng, M.-H. (2026). The Changing Etiological Landscape of Liver Cancer in the Era of Metabolic Disease. Liver international : official journal of the International Association for the Study of the Liver, vol. 46, p. e70781.
- Pugliese, N., White, T. M., Brennan, P. N., Pannain, S., Hagström, H., Michel, M., Rice-Duek, L., Targher, G., Caussy, C., Dillon, J. F., Tacke, F., Kopka, C. J., Sebastiani, G., Boursier, J., Tsochatzis, E. A., Brouwer, W. P., Guaraldi, G., Vettor, R., Thiele, M., Roden, M., Stefan, N., Jarvis, H., Gines, P., Schattenberg, J. M., Pose, E., Buttigieg, S., Byrne, C. D. & Lazarus, J. V. (2026). Diagnostic innovation and models of care to improve fibrosis detection and risk stratification in steatotic liver disease. The Lancet regional health. Europe, vol. 65, p. 101722.
- White, T. M., Sebastiani, G., Guaraldi, G., Pericàs, J. M., Fuster-Ruizdeapodaca, M. J. & Lazarus, J. V. (2026). A people-first, systems-oriented approach to liver disease in HIV infection. Nature reviews. Gastroenterology & hepatology, vol. 23, p. 600-601.
- Cinque, F., Nudo, M., Saeed, S., Lim, J., Kablawi, D., Mariano, G., Lupu, A., Elgretli, W., Moodie, E. E. M., Price, C., Monteith, K., Cooper, C., Walmsley, S., Kronfli, N., Cox, J., Costiniuk, C., De Pokomandy, A., Routy, J.-P., Klein, M. B., Lebouche, B. & Sebastiani, G. (2026). Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Impaired Health-Related Quality of Life in People With HIV. Gastro hep advances, vol. 5, p. 100966.
- Lei, S.-Y., Han, Y., Rockey, D. C., Alswat, K., Wong, V.-W., Jumaev, N., Toro-Huamanchumo, C. J., Taha, S., El-Kassas, M., George, J., Muthiah, M., Ghanem, O., Yoneda, M., Hang, D. V., Sebastiani, G., Papatheodoridis, G., Abu-Abeid, A., Robertson, A. G., Kim, S. H., Weiner, R., Mahawar, K., Shabbir, A., Kermansaravi, M., Rajan, R., Seki, Y., Taskin, H. E., Shikora, S., Oliveros, E., Parmar, C., Cheng, Q., Thaher, O., Ruiz-Úcar, E., Oviedo, R., Ribeiro, R., Musella, M., Ramos, A. C., Ryu, S.-W., Abdelbaki, T., Lee, W. J., Chan, M. P., Garcia Flores, J. E., Skinovsky, J., Madkhali, A., Weiner, S., Tacke, F., Yang, W., Neuberger, J., Zheng, M.-H. & International Obesity Society Working Group on Steatotic Liver Disease (2026). An international multidisciplinary consensus statement on laparoscopic liver biopsy. Cell reports. Medicine, vol. 7, p. 102831.
- Farhat, R., Zamora-Medina, M. D. C., Bae, S.-C., Barber, M. R. W., Clarke, A. E., Fortin, P. R., Touma, Z., Laskin, C. A., Malhamé, I., Sebastiani, G., Peschken, C., Ugarte-Gil, M. F., Legge, A., Bernatsky, S. & Vinet, É. (2026). Increased Risk of Intrahepatic Cholestasis of Pregnancy in Women With Systemic Lupus Erythematosus Exposed to Azathioprine. Arthritis & rheumatology (Hoboken, N.J.).
- Cinque, F., Saeed, S., Farina, F., Kablawi, D., Lim, J., Cascio, A., Gioè, C., Tsochatzis, E., Lombardi, R., Cordie, A., Mohamed, R., Kamel, A. M., Esmat, G., Bandera, A., Milic, J., Benke, D., Elamouri, F., Rockstroh, J. K., Guaraldi, G. & Sebastiani, G. (2026). FIB-4 fails to identify significant liver fibrosis in people with HIV: A large multinational screening study. Hepatology (Baltimore, Md.).
- Burnside, J., Djerboua, M., Flemming, J. A., Sebastiani, G., Wong, W. W. L., Lu, Z., Bajaj, H. S., Patel, K., Biondi, M., Betel, M., Nahwegahbow, A., Greenwald, Z. R., Moodie, E. E. M. & Saeed, S. (2026). Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis. Scientific reports, vol. 16.
Voir aussi
