Information sur le laboratoire
Giada Sebastiani (M.D.)
Scientifique séniorCentre de recherche évaluative en santé
Département de médecine (McGill)
Profil de recherche
Mots-clés
Stéatose hépatique • Biomarqueurs sériques hépatiques • Élastographie • VIH • Hépatite C • Hépatite BIntérêts de recherche
Mes recherches portent sur le dépistage de la fibrose hépatique et de la stéatose hépatique chez les populations à risque, notamment les patients séropositifs, les patients diabétiques et obèses, les femmes atteintes du syndrome des ovaires polykystiques et les patients atteints de maladies inflammatoires intestinales. Pour mener ces études, j'utilise des biomarqueurs sériques de la fibrose et un appareil non invasif, basé sur les ultrasons, appelé Fibroscan. Je suis également l'investigateur principal de plusieurs essais cliniques mondiaux portant sur des composés antifibrotiques dans la SHNA.Membre de l'équipe
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Dernières publications
- Kosick, H.-M., McIntosh, C., Bera, C., Fakhriyehasl, M., Shengir, M., Adeyi, O., Amiri, L., Sebastiani, G., Jhaveri, K. & Patel, K. (2025). Machine learning models using non-invasive tests & B-mode ultrasound to predict liver-related outcomes in metabolic dysfunction-associated steatotic liver disease. Scientific reports, vol. 15, p. 24579.
- Pennisi, G., Di Maria, G., Wai-Sun Wong, V., de Ledinghen, V., Sebastiani, G., Viganò, M., Fracanzani, A. L., Miele, L., Bugianesi, E., Ekstedt, M., D'Ambrosio, R., Ravaioli, F., Schepis, F., Marra, F., Aghemo, A., Svegliati-Baroni, G., Persico, M., Valenti, L., Berzigotti, A., George, J., Armandi, A., Nasr, P., Kechagias, S., Liguori, A., Saltini, D., Mendoza, Y. P., Calvaruso, V., Enea, M., Lin, H., Infantino, G., Masarone, M., Pugliese, N., Tulone, A., Di Marco, V., Cammà, C. & Petta, S. (2025). Impact of first and further decompensation in patients with compensated ACLD due to MASLD. Journal of hepatology.
- Shengir, M., Elgretli, W., Cinque, F., Ramanakumar, A. V., Lombardi, R., Cespiati, A., Fracanzani, A. L., Ballesteros, L., Deschenes, M., Wong, P., Chen, T. & Sebastiani, G. (2025). Metabolic Factors Drive Early Increase in Hepatic Steatosis Despite Improvement in Non-Invasive Fibrosis Markers after Hepatitis C Eradication with Direct-Acting Antivirals. Clinics and research in hepatology and gastroenterology, p. 102639.
- Kronfli, N., Mambro, A., O'Brien, A., Dussault, C., Chalifoux, S., Balso, L. D., Petropoulos, A., Lim, M., Halavrezos, A., Lebouche, B., Sebastiani, G., Klein, M. B. & Cox, J. (2025). A pre-post study of the impact of a multidisciplinary model of care on linkage to hepatitis C care following release from prison: The Beyond Prison Walls study. The International journal on drug policy, vol. 143, p. 104873.
- Lee, T.-H., Wegermann, K., Sutha, K., Cholankeril, G., Chu, C.-Y., Nguyen Galvan, N. T., Rana, A., Goss, J. A., Lambing, T., Cinque, F., Sebastiani, G., Patel, K., Naggie, S. & Wolfe, C. R. (2025). Beyond the HOPE Act: Roadmap to Expanding Kidney and Liver Transplants for People with Human Immunodeficiency Virus Utilizing Grafts from Donors with Human Immunodeficiency Virus. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
- Cinque, F. & Sebastiani, G. (2025). Lifestyle first: tackling MASLD in people living with HIV. The lancet. HIV, vol. 12, p. e394-e395.
- Burnside, J., Cinque, F., Sebastiani, G., Ramji, A., Patel, K., Swain, M. & Saeed, S. (2025). Sex differences in the prevalence and cardiometabolic risk profiles of steatotic liver disease: A Canadian Longitudinal Study on Aging analysis. Canadian journal of public health = Revue canadienne de sante publique.
- Zanframundo, G., Dourado, E., Bauer-Ventura, I., Faghihi-Kashani, S., Yoshida, A., Loganathan, A., Rivero-Gallegos, D., Lim, D., Bozán, F., Sambataro, G., Bae, S. S., Yamano, Y., Bonella, F., Corte, T. J., Doyle, T. J., Fiorentino, D., Gonzalez-Gay, M. A., Hudson, M., Kuwana, M., Lundberg, I. E., Mammen, A., McHugh, N., Miller, F. W., Montecucco, C., Oddis, C. V., Rojas-Serrano, J., Schmidt, J., Selva-O'Callaghan, A., Werth, V. P., Hansen, P., Rozza, D., Scirè, C. A., Sakellariou, G., Kaneko, Y., Triantafyllias, K., Castañeda, S., Alberti, M. L., Merino, M. G. G., Fiehn, C., Molad, Y., Govoni, M., Nakashima, R., Alpsoy, E., Giannini, M., Chinoy, H., Gallay, L., Ebstein, E., Campagne, J., Saraiva, A. P., Conticini, E., Sebastiani, G. D., Nuño-Nuño, L., Scarpato, S., Schiopu, E., Parker, M., Limonta, M., CLASS project participating investigators, Cavagna, L. & Aggarwal, R. (2025). The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project. Annals of the rheumatic diseases, vol. 84, p. 1207-1220.
- Feng, G., Yilmaz, Y., Valenti, L., Seto, W.-K., Pan, C. Q., Méndez-Sánchez, N., Ye, F., Sookoian, S., Targher, G., Byrne, C. D., Chan, W.-K., Treeprasertsuk, S., Yu, H. H., Kim, S. U., George, J., Xu, W.-J., Sebastiani, G., Ocama, P., Ryan, J. D., Lupșor-Platon, M., Ghazinyan, H., Hamid, S., Perera, N., Alswat, K., Isakov, V., Pan, Q., Sarin, S. K., Schattenberg, J. M., Sotoudeheian, M., Wong, Y. J., Sharara, A. I., Al-Busafi, S. A., Opio, C. K., Chai, J., Fouad, Y., Shi, Y., Al-Mahtab, M., Zhang, S., Pirola, C. J., Wong, V.-W. & Zheng, M.-H. (2025). Global Burden of Major Chronic Liver Diseases in 2021. Liver international : official journal of the International Association for the Study of the Liver, vol. 45, p. e70058.
- Feng, G., Targher, G., Byrne, C. D., Yilmaz, Y., Wai-Sun Wong, V., Adithya Lesmana, C. R., Adams, L. A., Boursier, J., Papatheodoridis, G., El-Kassas, M., Méndez-Sánchez, N., Sookoian, S., Castera, L., Chan, W.-K., Ye, F., Treeprasertsuk, S., Cortez-Pinto, H., Yu, H. H., Kim, W., Romero-Gómez, M., Nakajima, A., Win, K. M., Kim, S. U., Holleboom, A. G., Sebastiani, G., Ocama, P., Ryan, J. D., Lupșor-Platon, M., Ghazinyan, H., Al-Mahtab, M., Hamid, S., Perera, N., Alswat, K. A., Pan, Q., Long, M. T., Isakov, V., Mi, M., Arrese, M., Sanyal, A. J., Sarin, S. K., Leite, N. C., Valenti, L., Newsome, P. N., Hagström, H., Petta, S., Yki-Järvinen, H., Schattenberg, J. M., Castellanos Fernández, M. I., Leclercq, I. A., Aghayeva, G., Elzouki, A.-N., Tumi, A., Sharara, A. I., Labidi, A., Sanai, F. M., Matar, K., Al-Mattooq, M., Akroush, M. W., Benazzouz, M., Debzi, N., Alkhatry, M., Barakat, S., Al-Busafi, S. A., Rwegasha, J., Yang, W., Adwoa, A., Opio, C. K., Sotoudeheian, M., Wong, Y. J., George, J. & Zheng, M.-H. (2025). Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021. JHEP reports : innovation in hepatology, vol. 7, p. 101271.
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