Information sur le laboratoire
Giada Sebastiani (M.D.)
Scientifique séniorCentre de recherche évaluative en santé
Département de médecine (McGill)
Profil de recherche
Mots-clés
Stéatose hépatique • Biomarqueurs sériques hépatiques • Élastographie • VIH • Hépatite C • Hépatite BIntérêts de recherche
Mes recherches portent sur le dépistage de la fibrose hépatique et de la stéatose hépatique chez les populations à risque, notamment les patients séropositifs, les patients diabétiques et obèses, les femmes atteintes du syndrome des ovaires polykystiques et les patients atteints de maladies inflammatoires intestinales. Pour mener ces études, j'utilise des biomarqueurs sériques de la fibrose et un appareil non invasif, basé sur les ultrasons, appelé Fibroscan. Je suis également l'investigateur principal de plusieurs essais cliniques mondiaux portant sur des composés antifibrotiques dans la SHNA.Membre de l'équipe
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Dernières publications
- Yoshida, E. M., Bain, V. G., Coffin, C. S., Congly, S. E., Lee, S. S., Montano-Loza, A. J., Sebastiani, G. & Chandok, N. (2026). Canadian hepatology needs a strong, united Canada. Canadian liver journal, vol. 9, p. 343-344.
- Kehar, M., Ramji, A., Swain, M., Singer, A., Ivers, N., Schaufert, W., Betel, M., Dasgupta, K., Sebastiani, G. & Patel, K. (2026). Metabolic dysfunction-associated steatotic liver disease assessment and management: Clinical practice guidance from the Canadian Association for the Study of the Liver. Canadian liver journal, vol. 9, p. 345-388.
- de Avila, L., AlNaamani, K. M., Papatheodoridi, M., Petta, S., Hagström, H., Kim, S. U., Nakajima, A., Crespo, J., Castera, L., Alkhouri, N., Zheng, M.-H., Treeprasertsuk, S., , Tsochatzis, E., Trivikrama, S. K., Fan, J.-G., Roberts, S. K., Alswat, K., Wong, V.-W., Yilmaz, Y., Dunn, W., Francque, S., Cordie, A., Yu, M.-L., Ekstedt, M., Goh, G.-B., Oliveira, C. P., Pessoa, M. G., Chan, W. K., Castellanos Fernandez, M. I., Duseja, A., Arab, J. P., Papatheodoridis, G., Sebastiani, G., Villela-Nogueira, C., D'Ambrosio, R., Lampertico, P., Holleboom, A. G., Valsan, A., El-Kassas, M., Kobayashi, T., Kakizaki, S., Caussy, C., Pearlman, B., Pugliese, N., Vessby, J., Choudhary, N. S., Kawaguchi, T., Russo, F. P., Gadano, A., Diaz, L. A., Singal, A. K., Gunn, N., Mauricio, D., Arrese, M., Fracanzani, A., Lombardi, R., Aghemo, A., Alqahtani, S. A., Stepanova, M., Younossi, Z. M., Global MASLD Study Investigators on behalf of the Global NASH/MASH Council , Ananchuensook, P., Balakumaran, L. K., Lam, B., Venu, A., Pennisi, G., Shang, Y., Liu, W.-Y., Lee, H. W., Iruzubieta, P., Nadeem, R., Cinque, F., Zoncapé, M., Yang, R.-X., Song, S. J., Dunn, N., Gadi, Z., Yeh, M.-L., Teh, K.-K., Mahadeva, S., Fabian, L. G., Almohsen, A., Leite, N., Xie, C., Friend, E., Poca, M., Segrestin, B. & Racila, A. (2026). Histologic Features and Clinical Outcomes of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease. JAMA.
- Cordie, A., Mohamed, R., Sebastiani, G., El Garhy, N., Al Sehemy, L., Saweres, A., Nagy, M. S., Awad, R. A., Atef, R., Al-Sharif, A. M., Awadh, M. Y., Ramadan, D., Al-Shayeb, A., El Khateeb, E., Tamim, H. H., Hamza, R. S., El Saadany, Z., Esmat, G. & Omar, H. (2026). Prevalence of steatotic liver disease phenotypes and liver fibrosis in people with HIV in Egypt. Transactions of the Royal Society of Tropical Medicine and Hygiene.
- Milic, J., Carobbio, A., Menozzi, M., Mancini, G., Cuomo, G., Manicardi, M., Mussi, C., Mussini, C., Raggi, P., Sebastiani, G. & Guaraldi, G. (2026). Statin use is associated with improved frailty trajectories in people with HIV. The journals of gerontology. Series A, Biological sciences and medical sciences.
- Sebastiani, G., Lee, T.-H., Cordie, A., Cinque, F., Lake, J. E., Lazarus, J. V., Rockstroh, J. K. & Guaraldi, G. (2026). Metabolic dysfunction-associated steatotic liver disease in people living with HIV: a framework for integrated screening and care. The lancet. HIV, vol. 13, p. e745-e756.
- Ko, H. H., Vienneau, J., Cooper, C. L., Crotty, P., Congly, S. E., Brahmania, M., Ramji, A., Kelly, E., Crawley, A. M., Doucette, K., Meier-Stephenson, V., Ma, M., Fung, S. K., Wong, D. K., Feld, J., Faisal, N., Kaita, K., Osiowy, C., Elkhashab, M., Tam, E., Wong, A., Bailey, R., Wong, P., Sebastiani, G., Chen, T., Conway, B., Truong, D., Tsoi, K., Nudo, C., Zhu, J., Poulin, S., Shaheen, A.-A. & Coffin, C. S. (2026). Barriers to Hepatitis B Treatment: A Multicentre Cross-Sectional Registry and Survey Study by the Canadian Hepatitis B Network. Liver international : official journal of the International Association for the Study of the Liver, vol. 46, p. e70835.
- Rapino, C., Sebastiani, G., Burnside, J., Wen, C., Ramji, A., Swain, M., Patel, K. & Saeed, S. (2026). Time-Varying Impact of Steatosis and Alcohol on Mortality: A Marginal Structural Model of the Canadian Longitudinal Study on Aging. Liver international : official journal of the International Association for the Study of the Liver, vol. 46, p. e70833.
- Burnside, J., Djerboua, M., Flemming, J. A., Sebastiani, G., Wong, W. W. L., Lu, Z., Bajaj, H. S., Patel, K., Biondi, M., Betel, M., Nahwegahbow, A., Greenwald, Z. R., Moodie, E. E. M. & Saeed, S. (2026). Correction: Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis. Scientific reports, vol. 16.
- Marquardt, J., Ota, R., Sebastiani, G., Baca, D. M., Wallinger, H., Quinones, E., Amari, L. & Bugianesi, E. (2026). Reply to "Real-world quality of life and healthcare resource utilization in patients with metabolic dysfunction-associated steatohepatitis - Circular definition of CVRM comorbidities undermines the validity of core subgroup comparisons". JHEP reports : innovation in hepatology, p. 101972.
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