Information sur le laboratoire
Giada Sebastiani (M.D.)
Scientifique séniorCentre de recherche évaluative en santé
Département de médecine (McGill)
Profil de recherche
Mots-clés
Stéatose hépatique • Biomarqueurs sériques hépatiques • Élastographie • VIH • Hépatite C • Hépatite BIntérêts de recherche
Mes recherches portent sur le dépistage de la fibrose hépatique et de la stéatose hépatique chez les populations à risque, notamment les patients séropositifs, les patients diabétiques et obèses, les femmes atteintes du syndrome des ovaires polykystiques et les patients atteints de maladies inflammatoires intestinales. Pour mener ces études, j'utilise des biomarqueurs sériques de la fibrose et un appareil non invasif, basé sur les ultrasons, appelé Fibroscan. Je suis également l'investigateur principal de plusieurs essais cliniques mondiaux portant sur des composés antifibrotiques dans la SHNA.Membre de l'équipe
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Dernières publications
- Feng, G., Targher, G., Byrne, C. D., Yilmaz, Y., Wai-Sun Wong, V., Adithya Lesmana, C. R., Adams, L. A., Boursier, J., Papatheodoridis, G., El-Kassas, M., Méndez-Sánchez, N., Sookoian, S., Castera, L., Chan, W.-K., Ye, F., Treeprasertsuk, S., Cortez-Pinto, H., Yu, H. H., Kim, W., Romero-Gómez, M., Nakajima, A., Win, K. M., Kim, S. U., Holleboom, A. G., Sebastiani, G., Ocama, P., Ryan, J. D., Lupșor-Platon, M., Ghazinyan, H., Al-Mahtab, M., Hamid, S., Perera, N., Alswat, K. A., Pan, Q., Long, M. T., Isakov, V., Mi, M., Arrese, M., Sanyal, A. J., Sarin, S. K., Leite, N. C., Valenti, L., Newsome, P. N., Hagström, H., Petta, S., Yki-Järvinen, H., Schattenberg, J. M., Castellanos Fernández, M. I., Leclercq, I. A., Aghayeva, G., Elzouki, A.-N., Tumi, A., Sharara, A. I., Labidi, A., Sanai, F. M., Matar, K., Al-Mattooq, M., Akroush, M. W., Benazzouz, M., Debzi, N., Alkhatry, M., Barakat, S., Al-Busafi, S. A., Rwegasha, J., Yang, W., Adwoa, A., Opio, C. K., Sotoudeheian, M., Wong, Y. J., George, J. & Zheng, M.-H. (2025). Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021. JHEP reports : innovation in hepatology, vol. 7, p. 101271.
- Elgretli, W., Shengir, M., Sasson, S., Ramanakumar, A. V., Cinque, F., Ballestreros, L. E. R., Deschenes, M., Wong, P., Chen, T., Kronfli, N., Saeed, S., Keeshan, A., Tandon, S., Cooper, C. & Sebastiani, G. (2025). Association of MASLD Phenotypes With Liver Fibrosis in Hepatitis C: The Role of Cardiometabolic Risk Factors. Journal of viral hepatitis, vol. 32, p. e70004.
- Righetti, R., Cinque, F., Patel, K. & Sebastiani, G. (2025). The role of noninvasive biomarkers for monitoring cell injury in advanced liver fibrosis. Expert review of gastroenterology & hepatology, p. 1-16.
- Pradhan, R., Yin, H., Lu, S., Sebastiani, G., Yu, O., Suissa, S. & Azoulay, L. (2025). Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors and the Prevention of Cirrhosis Among Patients With Type 2 Diabetes. Diabetes care, vol. 48, p. 444-454.
- Wu, C., Targher, G., Byrne, C. D., Mao, Y., Cheung, T. T., Yilmaz, Y., Valenti, L., Méndez-Sánchez, N., Sookoian, S., Chan, W.-K., Treeprasertsuk, S., Yu, H. H., Kim, S. U., George, J., Hu, D., Sebastiani, G., Ryan, J. D., Oviedo, R. J., Zhong, J.-H., Schattenberg, J. M., Lonardo, A., Ruiz-Úcar, E., Seto, W.-K., Sotoudeheian, M., Ocama, P., Lupșor-Platon, M., Yang, T., Ghazinyan, H., Pan, Q., Hamid, S., Adams, L., Chai, J., Prasad, A., Perera, N., Alswat, K., Isakov, V., Sarin, S. K., Sharara, A. I., Sanai, F. M., Al-Busafi, S. A., Opio, C. K., Toro-Huamanchumo, C. J., Yang, W., Wong, Y. J., Torzilli, G., Fouad, Y. & Zheng, M.-H. (2025). Global, regional, and national burden of primary liver cancer attributable to metabolic risks: an analysis of the Global Burden of Disease Study 1990-2021. The American journal of gastroenterology.
- Romano, J., Burnside, J., Sebastiani, G., Ramji, A., Patel, K., Swain, M. & Saeed, S. (2024). Examining the prevalence of hepatic steatosis and advanced fibrosis using non-invasive measures across Canada: A national estimate using the Canadian Health Measures Survey (CHMS) from 2009-2019. Annals of hepatology, p. 101757.
- Kronfli, N., Mambro, A., Riback, L. R., Ortiz-Paredes, D., Dussault, C., Chalifoux, S., Del Balso, L., Petropoulos, A., Lim, M., Halavrezos, A., Sebastiani, G., Klein, M. B., Lebouche, B., Cox, J. & Akiyama, M. J. (2024). Perceived patient navigator services and characteristics to address barriers to linkage to hepatitis C care among people released from provincial prison in Quebec, Canada. The International journal on drug policy, vol. 133, p. 104624.
- Truscello, E., Wang, S., Young, J., Sebastiani, G., Walmsley, S. L., Hull, M., Cooper, C. & Klein, M. B. (2025). Changes in hepatic steatosis before and after direct acting antiviral treatment in people living with HIV and Hepatitis C coinfection. The Journal of infectious diseases, vol. 231, p. e101-e112.
- Zeng, X.-F., Varady, K. A., Wang, X.-D., Targher, G., Byrne, C. D., Tayyem, R., Latella, G., Bergheim, I., Valenzuela, R., George, J., Newberry, C., Zheng, J.-S., George, E. S., Spearman, C. W., Kontogianni, M. D., Ristic-Medic, D., Peres, W. A. F., Depboylu, G. Y., Yang, W., Chen, X., Rosqvist, F., Mantzoros, C. S., Valenti, L., Yki-Järvinen, H., Mosca, A., Sookoian, S., Misra, A., Yilmaz, Y., Kim, W., Fouad, Y., Sebastiani, G., Wong, V.-W., Åberg, F., Wong, Y. J., Zhang, P., Bermúdez-Silva, F.-J., Ni, Y., Lupsor-Platon, M., Chan, W. K., Méndez-Sánchez, N., de Knegt, R. J., Alam, S., Treeprasertsuk, S., Wang, L., Du, M., Zhang, T., Yu, M.-L., Zhang, H., Qi, X., Liu, X., Pinyopornpanish, K., Fan, Y.-C., Kaijun, N., Jimenez-Chillaron, J. C. & Zheng, M.-H. (2024). The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: an international multidisciplinary expert consensus. Metabolism: clinical and experimental, p. 156028.
- Volniansky, A., Lefebvre, T. L., Kulbay, M., Fan, B., Aslan, E., Vu, K.-N., Montagnon, E., Nguyen, B. N., Sebastiani, G., Giard, J.-M., Sylvestre, M.-P., Gilbert, G., Cloutier, G. & Tang, A. (2024). Inter-visit and inter-reader reproducibility of multi-parametric diffusion-weighted MR imaging in longitudinally imaged patients with metabolic dysfunction-associated fatty liver disease and healthy volunteers. Magnetic resonance imaging, vol. 113, p. 110223.
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