Information sur le laboratoire
Giada Sebastiani (M.D.)
Scientifique séniorCentre de recherche évaluative en santé
Département de médecine (McGill)
Profil de recherche
Mots-clés
Stéatose hépatique • Biomarqueurs sériques hépatiques • Élastographie • VIH • Hépatite C • Hépatite BIntérêts de recherche
Mes recherches portent sur le dépistage de la fibrose hépatique et de la stéatose hépatique chez les populations à risque, notamment les patients séropositifs, les patients diabétiques et obèses, les femmes atteintes du syndrome des ovaires polykystiques et les patients atteints de maladies inflammatoires intestinales. Pour mener ces études, j'utilise des biomarqueurs sériques de la fibrose et un appareil non invasif, basé sur les ultrasons, appelé Fibroscan. Je suis également l'investigateur principal de plusieurs essais cliniques mondiaux portant sur des composés antifibrotiques dans la SHNA.Membre de l'équipe
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Dernières publications
- Zanframundo, G., Dourado, E., Bauer-Ventura, I., Faghihi-Kashani, S., Yoshida, A., Loganathan, A., Rivero-Gallegos, D., Lim, D., Bozán, F., Sambataro, G., Bae, S. S., Yamano, Y., Bonella, F., Corte, T. J., Doyle, T. J., Fiorentino, D., Gonzalez-Gay, M. A., Hudson, M., Kuwana, M., Lundberg, I. E., Mammen, A., McHugh, N., Miller, F. W., Montecucco, C., Oddis, C. V., Rojas-Serrano, J., Schmidt, J., Selva-O'Callaghan, A., Werth, V. P., Hansen, P., Rozza, D., Scirè, C. A., Sakellariou, G., Kaneko, Y., Triantafyllias, K., Castañeda, S., Alberti, M. L., Merino, M. G. G., Fiehn, C., Molad, Y., Govoni, M., Nakashima, R., Alpsoy, E., Giannini, M., Chinoy, H., Gallay, L., Ebstein, E., Campagne, J., Saraiva, A. P., Conticini, E., Sebastiani, G. D., Nuño-Nuño, L., Scarpato, S., Schiopu, E., Parker, M., Limonta, M., CLASS project participating investigators, Cavagna, L. & Aggarwal, R. (2025). The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project. Annals of the rheumatic diseases.
- Feng, G., Yilmaz, Y., Valenti, L., Seto, W.-K., Pan, C. Q., Méndez-Sánchez, N., Ye, F., Sookoian, S., Targher, G., Byrne, C. D., Chan, W.-K., Treeprasertsuk, S., Yu, H. H., Kim, S. U., George, J., Xu, W.-J., Sebastiani, G., Ocama, P., Ryan, J. D., Lupșor-Platon, M., Ghazinyan, H., Hamid, S., Perera, N., Alswat, K., Isakov, V., Pan, Q., Sarin, S. K., Schattenberg, J. M., Sotoudeheian, M., Wong, Y. J., Sharara, A. I., Al-Busafi, S. A., Opio, C. K., Chai, J., Fouad, Y., Shi, Y., Al-Mahtab, M., Zhang, S., Pirola, C. J., Wong, V.-W. & Zheng, M.-H. (2025). Global Burden of Major Chronic Liver Diseases in 2021. Liver international : official journal of the International Association for the Study of the Liver, vol. 45, p. e70058.
- Feng, G., Targher, G., Byrne, C. D., Yilmaz, Y., Wai-Sun Wong, V., Adithya Lesmana, C. R., Adams, L. A., Boursier, J., Papatheodoridis, G., El-Kassas, M., Méndez-Sánchez, N., Sookoian, S., Castera, L., Chan, W.-K., Ye, F., Treeprasertsuk, S., Cortez-Pinto, H., Yu, H. H., Kim, W., Romero-Gómez, M., Nakajima, A., Win, K. M., Kim, S. U., Holleboom, A. G., Sebastiani, G., Ocama, P., Ryan, J. D., Lupșor-Platon, M., Ghazinyan, H., Al-Mahtab, M., Hamid, S., Perera, N., Alswat, K. A., Pan, Q., Long, M. T., Isakov, V., Mi, M., Arrese, M., Sanyal, A. J., Sarin, S. K., Leite, N. C., Valenti, L., Newsome, P. N., Hagström, H., Petta, S., Yki-Järvinen, H., Schattenberg, J. M., Castellanos Fernández, M. I., Leclercq, I. A., Aghayeva, G., Elzouki, A.-N., Tumi, A., Sharara, A. I., Labidi, A., Sanai, F. M., Matar, K., Al-Mattooq, M., Akroush, M. W., Benazzouz, M., Debzi, N., Alkhatry, M., Barakat, S., Al-Busafi, S. A., Rwegasha, J., Yang, W., Adwoa, A., Opio, C. K., Sotoudeheian, M., Wong, Y. J., George, J. & Zheng, M.-H. (2025). Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021. JHEP reports : innovation in hepatology, vol. 7, p. 101271.
- Elgretli, W., Shengir, M., Sasson, S., Ramanakumar, A. V., Cinque, F., Ballestreros, L. E. R., Deschenes, M., Wong, P., Chen, T., Kronfli, N., Saeed, S., Keeshan, A., Tandon, S., Cooper, C. & Sebastiani, G. (2025). Association of MASLD Phenotypes With Liver Fibrosis in Hepatitis C: The Role of Cardiometabolic Risk Factors. Journal of viral hepatitis, vol. 32, p. e70004.
- Righetti, R., Cinque, F., Patel, K. & Sebastiani, G. (2025). The role of noninvasive biomarkers for monitoring cell injury in advanced liver fibrosis. Expert review of gastroenterology & hepatology, p. 1-16.
- Pradhan, R., Yin, H., Lu, S., Sebastiani, G., Yu, O., Suissa, S. & Azoulay, L. (2025). Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors and the Prevention of Cirrhosis Among Patients With Type 2 Diabetes. Diabetes care, vol. 48, p. 444-454.
- Wu, C., Targher, G., Byrne, C. D., Mao, Y., Cheung, T. T., Yilmaz, Y., Valenti, L., Méndez-Sánchez, N., Sookoian, S., Chan, W.-K., Treeprasertsuk, S., Yu, H. H., Kim, S. U., George, J., Hu, D., Sebastiani, G., Ryan, J. D., Oviedo, R. J., Zhong, J.-H., Schattenberg, J. M., Lonardo, A., Ruiz-Úcar, E., Seto, W.-K., Sotoudeheian, M., Ocama, P., Lupșor-Platon, M., Yang, T., Ghazinyan, H., Pan, Q., Hamid, S., Adams, L., Chai, J., Prasad, A., Perera, N., Alswat, K., Isakov, V., Sarin, S. K., Sharara, A. I., Sanai, F. M., Al-Busafi, S. A., Opio, C. K., Toro-Huamanchumo, C. J., Yang, W., Wong, Y. J., Torzilli, G., Fouad, Y. & Zheng, M.-H. (2025). Global, regional, and national burden of primary liver cancer attributable to metabolic risks: an analysis of the Global Burden of Disease Study 1990-2021. The American journal of gastroenterology.
- Romano, J., Burnside, J., Sebastiani, G., Ramji, A., Patel, K., Swain, M. & Saeed, S. (2024). Examining the prevalence of hepatic steatosis and advanced fibrosis using non-invasive measures across Canada: A national estimate using the Canadian Health Measures Survey (CHMS) from 2009-2019. Annals of hepatology, p. 101757.
- Kronfli, N., Mambro, A., Riback, L. R., Ortiz-Paredes, D., Dussault, C., Chalifoux, S., Del Balso, L., Petropoulos, A., Lim, M., Halavrezos, A., Sebastiani, G., Klein, M. B., Lebouche, B., Cox, J. & Akiyama, M. J. (2024). Perceived patient navigator services and characteristics to address barriers to linkage to hepatitis C care among people released from provincial prison in Quebec, Canada. The International journal on drug policy, vol. 133, p. 104624.
- Truscello, E., Wang, S., Young, J., Sebastiani, G., Walmsley, S. L., Hull, M., Cooper, C. & Klein, M. B. (2025). Changes in hepatic steatosis before and after direct acting antiviral treatment in people living with HIV and Hepatitis C coinfection. The Journal of infectious diseases, vol. 231, p. e101-e112.
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