Lab Information

Donald Sheppard (MD)

Senior Scientist
Centre for Translational Biology
Department of Microbiology & Immunology (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Medical mycology • aspergillus • biofilms • host-pathogen interactions

Research Interests

My research focuses on understanding how molds and other fungi cause human disease. Recently, our laboratory discovered that fungi secrete sugars that can act as a glue in order to help fungi attach to human lung cells and hide from the immune system during lung infections. My research focuses on fungi that infect humans. In particular, we focus on the common mold Aspergillus fumigatus, which causes pneumonia in patients who have received chemotherapy, organ transplantation, bone marrow transplantation or high dose cortisone therapy. Despite the use of current antifungal drugs, this pneumonia is fatal for more than half the affected patients. Our group is working to identify how this fungus invades human tissues in order to develop new, more effective antifungal therapies to prevent and cure this aggressive and common condition.


Team Members

Name Position

Latest Publications

  1. Razvi, E., Whitfield, G. B., Reichhardt, C., Dreifus, J. E., Willis, A. R., Gluscencova, O. B., Gloag, E. S., Awad, T. S., Rich, J. D., da Silva, D. P., Bond, W., Le Mauff, F., Sheppard, D. C., Hatton, B. D., Stoodley, P., Reinke, A. W., Boulianne, G. L., Wozniak, D. J., Harrison, J. J., Parsek, M. R. & Howell, P. L. (2023). Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence. NPJ biofilms and microbiomes, vol. 9, p. 7.
  2. Le Mauff, F. & Sheppard, D. C. (2023). Understanding Aspergillus fumigatus galactosaminogalactan biosynthesis: A few questions remain. Cell surface (Amsterdam, Netherlands), vol. 9, p. 100095.
  3. Sarden, N., Sinha, S., Potts, K. G., Pernet, E., Hiroki, C. H., Hassanabad, M. F., Nguyen, A. P., Lou, Y., Farias, R., Winston, B. W., Bromley, A., Snarr, B. D., Zucoloto, A. Z., Andonegui, G., Muruve, D. A., McDonald, B., Sheppard, D. C., Mahoney, D. J., Divangahi, M., Rosin, N., Biernaskie, J. & Yipp, B. G. (2022). A B1a-natural IgG-neutrophil axis is impaired in viral- and steroid-associated aspergillosis. Science translational medicine, vol. 14, p. eabq6682.
  4. Liu, S., Le Mauff, F., Sheppard, D. C. & Zhang, S. (2022). Filamentous fungal biofilms: Conserved and unique aspects of extracellular matrix composition, mechanisms of drug resistance and regulatory networks in Aspergillus fumigatus. NPJ biofilms and microbiomes, vol. 8, p. 83.
  5. Case, N. T., Berman, J., Blehert, D. S., Cramer, R. A., Cuomo, C., Currie, C. R., Ene, I. V., Fisher, M. C., Fritz-Laylin, L. K., Gerstein, A. C., Glass, N. L., Gow, N. A. R., Gurr, S. J., Hittinger, C. T., Hohl, T. M., Iliev, I. D., James, T. Y., Jin, H., Klein, B. S., Kronstad, J. W., Lorch, J. M., McGovern, V., Mitchell, A. P., Segre, J. A., Shapiro, R. S., Sheppard, D. C., Sil, A., Stajich, J. E., Stukenbrock, E. E., Taylor, J. W., Thompson, D., Wright, G. D., Heitman, J. & Cowen, L. E. (2022). The future of fungi: threats and opportunities. G3 (Bethesda, Md.), vol. 12.
  6. Ostapska, H., Raju, D., Corsini, R., Lehoux, M., Lacdao, I., Gilbert, S., Sivarajah, P., Bamford, N. C., Baker, P., Gravelat, F. N., Howell, P. L. & Sheppard, D. C. (2022). Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection. Antimicrobial agents and chemotherapy, vol. 66, p. e0005222.
  7. Phan, Q. T., Solis, N. V., Lin, J., Swidergall, M., Singh, S., Liu, H., Sheppard, D. C., Ibrahim, A. S., Mitchell, A. P. & Filler, S. G. (2022). Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells. PLoS pathogens, vol. 18, p. e1010681.
  8. Le Mauff, F., Razvi, E., Reichhardt, C., Sivarajah, P., Parsek, M. R., Howell, P. L. & Sheppard, D. C. (2022). Author Correction: The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine. Communications biology, vol. 5, p. 624.
  9. Dietschmann, A., Schruefer, S., Westermann, S., Henkel, F., Castiglione, K., Willebrand, R., Adam, J., Ruland, J., Lang, R., Sheppard, D. C., Esser-von-Bieren, J., Radtke, D., Krappmann, S. & Voehringer, D. (2022). Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling. mBio, vol. 13, p. e0123922.
  10. Le Mauff, F., Razvi, E., Reichhardt, C., Sivarajah, P., Parsek, M. R., Howell, P. L. & Sheppard, D. C. (2022). The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine. Communications biology, vol. 5, p. 502.
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