Lab Information
Ciriaco Piccirillo (PhD)
Senior ScientistCentre for Translational Biology
Department of Microbiology & Immunology (McGill)
Research Profile
http://www.piccirillolab.wix.com/piccirillolab
Keywords
Immunology • T cell biology • autoimmune diseases • inflammatory diseasesResearch Interests
My research focuses on the regulation of innate and adaptive immune responses mediated by Foxp3+ regulatory T (Treg) cells, a unique population of CD4+ T cells with potent immunosuppressive functions in humans and mice. Normal development and function of Foxp3+ Treg cells is essential for the protection from autoimmune diseases and developmental or functional defects in Treg cells in mice and humans unequivocally provokes many inflammatory and autoimmune diseases. Our research is responsible for many seminal studies over the past decade related to the function and mechanism of action of Treg cells in a variety of animal models, non-human primates and humans. My research program aims to determine whether Treg cell developmental, functional or homeostatic deficiencies trigger various inflammatory disorders, and in particular autoimmune diseases like type 1 diabetes (T1D). My laboratory exploits a spectrum of molecular and cellular approaches to study the development, dynamics and molecular basis of Treg cell function in health and disease.Team Members
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Latest Publications
- Vucetic, A., Lafleur, A., Côté, M., Kobasa, D., Chan, M., Alvarez, F., Piccirillo, C., Dong, G. & Olivier, M. (2023). Extracellular vesicle storm during the course of Ebola virus infection in primates. Frontiers in cellular and infection microbiology, vol. 13, p. 1275277.
- Al-Aubodah, T.-A., Aoudjit, L., Pascale, G., Perinpanayagam, M. A., Langlais, D., Bitzan, M., Samuel, S. M., Piccirillo, C. A. & Takano, T. (2023). The extrafollicular B cell response is a hallmark of childhood idiopathic nephrotic syndrome. Nature communications, vol. 14, p. 7682.
- Perera, D. J., Domenech, P., Babuadze, G. G., Naghibosadat, M., Alvarez, F., Koger-Pease, C., Labrie, L., Stuible, M., Durocher, Y., Piccirillo, C. A., Lametti, A., Fiset, P. O., Elahi, S. M., Kobinger, G. P., Gilbert, R., Olivier, M., Kozak, R., Reed, M. B. & Ndao, M. (2023). BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine. iScience, vol. 26, p. 107612.
- N'Guessan, A., Kailasam, S., Mostefai, F., Poujol, R., Grenier, J.-C., Ismailova, N., Contini, P., De Palma, R., Haber, C., Stadler, V., Bourque, G., Hussin, J. G., Shapiro, B. J., Fritz, J. H. & Piccirillo, C. A. (2023). Selection for immune evasion in SARS-CoV-2 revealed by high-resolution epitope mapping and sequence analysis. iScience, vol. 26, p. 107394.
- Alvarez, F. & Piccirillo, C. A. (2023). The functional adaptation of effector Foxp3+ regulatory T cells to pulmonary inflammation. European journal of immunology, p. e2250273.
- Istomine, R., Al-Aubodah, T.-A., Alvarez, F., Smith, J. A., Wagner, C. & Piccirillo, C. A. (2023). The eIF4EBP-eIF4E axis regulates CD4+ T cell differentiation through modulation of T cell activation and metabolism. iScience, vol. 26, p. 106683.
- Alvarez, F., Istomine, R., Da Silva Lira Filho, A., Al-Aubodah, T.-A., Huang, D., Okde, R., Olivier, M., Fritz, J. H. & Piccirillo, C. A. (2023). IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections. Mucosal immunology, vol. 16, p. 462-475.
- Gimenez-Rivera, V.-A., Patel, H., Dupuy, F. P., Allakhverdi, Z., Bouchard, C., Madrenas, J., Bissonnette, R., Piccirillo, C. A. & Jack, C. (2023). NOD2 Agonism Counter-Regulates Human Type 2 T Cell Functions in Peripheral Blood Mononuclear Cell Cultures: Implications for Atopic Dermatitis. Biomolecules, vol. 13.
- Mehdi, A., Attias, M., Arakelian, A., Szyf, M., Piccirillo, C. A. & Rabbani, S. A. (2023). S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas. Neoplasia (New York, N.Y.), vol. 36, p. 100874.
- Mehdi, A., Attias, M., Arakelian, A., Piccirillo, C. A., Szyf, M. & Rabbani, S. A. (2022). Co-Targeting Luminal B Breast Cancer with S-Adenosylmethionine and Immune Checkpoint Inhibitor Reduces Primary Tumor Growth and Progression, and Metastasis to Lungs and Bone. Cancers, vol. 15.
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