Lab Information

Martin Olivier (PhD)

Senior Scientist
Centre for Translational Biology
Department of Microbiology & Immunology (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Leishmaniasis • malaria • exosome • innate inflammation • signaling

Research Interests

My research focuses on understanding how pathogens can evade the host immune response by manipulating the biochemical cascades involved in the regulation of phagocyte microbicidal functions. My pathogens of interest are protozoan parasites causing malaria, which causes up to two millions deaths annually, and leishmaniasis, which affects more than 250 million individuals worldwide. I have found that leishmania can tame the innate inflammatory response of the host, using its surface protease that can also be contained in microvesicules rapidly released within the host environment. For Malaria, my research revealed that a crystalline metabolic waste (HZ) of the parasite was responsible for a great number of inflammation-related pathologies encountered during this important infection. My lab's findings may lead to the development of new therapies against those infectious agents, which could be applied to others such as tuberculosis. They might also lead to the development of new diagnostic tools based on exo-biomarkers, and potentially to vaccine development.


Team Members

Name Position

Latest Publications

  1. da Silva Lira Filho, A., Fajardo, E. F., Chang, K. P., Clément, P. & Olivier, M. (2021). Leishmania Exosomes/Extracellular Vesicles Containing GP63 Are Essential for Enhance Cutaneous Leishmaniasis Development Upon Co-Inoculation of Leishmania amazonensis and Its Exosomes. Frontiers in cellular and infection microbiology, vol. 11, p. 709258.
  2. Abusarah, J., Khodayarian, F., El-Hachem, N., Salame, N., Olivier, M., Balood, M., Roversi, K., Talbot, S., Bikorimana, J.-P., Chen, J., Jolicoeur, M., Trudeau, L.-E., Kamyabiazar, S., Annabi, B., Robert, F., Pelletier, J., El-Kadiry, A. E., Shammaa, R. & Rafei, M. (2021). Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice. Cell reports. Medicine, vol. 2, p. 100455.
  3. Chan, A., Ayala, J.-M., Alvarez, F., Piccirillo, C., Dong, G., Langlais, D. & Olivier, M. (2021). The role of Leishmania GP63 in the modulation of innate inflammatory response to Leishmania major infection. PloS one, vol. 16, p. e0262158.
  4. Carvalho Cabral, P., Tekade, K., Stegeman, S. K., Olivier, M. & Cermakian, N. (2021). The involvement of host circadian clocks in the regulation of the immune response to parasitic infections in mammals. Parasite immunology, p. e12903.
  5. Heirwegh, E., MacLean, E., He, J., Kamhawi, S., Sagan, S. M. & Olivier, M. (2021). Sandfly Fever Sicilian Virus-Leishmania major co-infection modulates innate inflammatory response favoring myeloid cell infections and skin hyperinflammation. PLoS neglected tropical diseases, vol. 15, p. e0009638.
  6. Nguyen, A. M. T., Brettell, S., Douanne, N., Duquette, C., Corbeil, A., Fajardo, E. F., Olivier, M., Fernandez-Prada, C. & Lubell, W. D. (2021). Influence of N-Methylation and Conformation on Almiramide Anti-Leishmanial Activity. Molecules (Basel, Switzerland), vol. 26.
  7. Dong, G., Wagner, V., Minguez-Menendez, A., Fernandez-Prada, C. & Olivier, M. (2021). Extracellular vesicles and leishmaniasis: Current knowledge and promising avenues for future development. Molecular immunology, vol. 135, p. 73-83.
  8. Torrecilhas, A. C., Soares, R. P., Schenkman, S., Fernández-Prada, C. & Olivier, M. (2020). Extracellular Vesicles in Trypanosomatids: Host Cell Communication. Frontiers in cellular and infection microbiology, vol. 10, p. 602502.
  9. Vialard, F. & Olivier, M. (2020). Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?. Frontiers in immunology, vol. 11, p. 588387.
  10. Olivier, M. & Zamboni, D. S. (2020). Leishmania Viannia guyanensis, LRV1 virus and extracellular vesicles: a dangerous trio influencing the faith of immune response during muco-cutaneous leishmaniasis. Current opinion in immunology, vol. 66, p. 108-113.
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See also

Card image
Ciriaco
Piccirillo


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