Lab Information

Ciriaco Piccirillo (PhD)

Senior Scientist
Centre for Translational Biology
Department of Microbiology & Immunology (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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 http://www.piccirillolab.wix.com/piccirillolab

Keywords

Immunology • T cell biology • autoimmune diseases • inflammatory diseases

Research Interests

My research focuses on the regulation of innate and adaptive immune responses mediated by Foxp3+ regulatory T (Treg) cells, a unique population of CD4+ T cells with potent immunosuppressive functions in humans and mice. Normal development and function of Foxp3+ Treg cells is essential for the protection from autoimmune diseases and developmental or functional defects in Treg cells in mice and humans unequivocally provokes many inflammatory and autoimmune diseases. Our research is responsible for many seminal studies over the past decade related to the function and mechanism of action of Treg cells in a variety of animal models, non-human primates and humans. My research program aims to determine whether Treg cell developmental, functional or homeostatic deficiencies trigger various inflammatory disorders, and in particular autoimmune diseases like type 1 diabetes (T1D). My laboratory exploits a spectrum of molecular and cellular approaches to study the development, dynamics and molecular basis of Treg cell function in health and disease.


Team Members

Name Position

Latest Publications

  1. Datta, S. K., Horwitz, D. A., Piccirillo, C. A. & La Cava, A. (2022). Editorial: Generating and Sustaining Stable Autoantigen-Specific CD4 and CD8 Regulatory T Cells in Lupus. Frontiers in immunology, vol. 13, p. 838604.
  2. Chan, A., Ayala, J.-M., Alvarez, F., Piccirillo, C., Dong, G., Langlais, D. & Olivier, M. (2021). The role of Leishmania GP63 in the modulation of innate inflammatory response to Leishmania major infection. PloS one, vol. 16, p. e0262158.
  3. Verma, V., Drury, G. L., Parisien, M., Özdağ Acarli, A. N., Al-Aubodah, T.-A., Nijnik, A., Wen, X., Tugarinov, N., Verner, M., Klares, R., Linton, A., Krock, E., Morado Urbina, C. E., Winsvold, B., Fritsche, L. G., Fors, E. A., Piccirillo, C., Khoutorsky, A., Svensson, C. I., Fitzcharles, M. A., Ingelmo, P. M., Bernard, N. F., Dupuy, F. P., Üçeyler, N., Sommer, C., King, I. L., Meloto, C. B., Diatchenko, L. & HUNT-All In Pain (2021). Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia. Pain.
  4. Zhang, Y., Li, L., Genest, G., Zhao, W., Ke, D., Bartolucci, S., Pavey, N., Al-Aubodah, T.-A., Lejtenyi, D., Torabi, B., Ben-Shoshan, M., Mazer, B. & Piccirillo, C. A. (2021). Successful Milk Oral Immunotherapy Promotes Generation of Casein-Specific CD137+ FOXP3+ Regulatory T Cells Detectable in Peripheral Blood. Frontiers in immunology, vol. 12, p. 705615.
  5. Dziarmaga, R., Ke, D., Sapir-Pichhadze, R., Cardinal, H., Phan, V., Piccirillo, C. A., Mazer, B. & Foster, B. J. (2021). Age- and sex-mediated differences in T lymphocyte populations of kidney transplant recipients. Pediatric transplantation, p. e14150.
  6. Huang, F., Gonçalves, C., Bartish, M., Rémy-Sarrazin, J., Issa, M. E., Cordeiro, B., Guo, Q., Emond, A., Attias, M., Yang, W., Plourde, D., Su, J., Gimeno, M. G., Zhan, Y., Galán, A., Rzymski, T., Mazan, M., Masiejczyk, M., Faber, J., Khoury, E., Benoit, A., Gagnon, N., Dankort, D., Journe, F., Ghanem, G. E., Krawczyk, C. M., Saragovi, H. U., Piccirillo, C. A., Sonenberg, N., Topisirovic, I., Rudd, C. E., Miller, W. H. & Del Rincón, S. V. (2021). Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses. The Journal of clinical investigation, vol. 131.
  7. Grover, P., Goel, P. N., Piccirillo, C. A. & Greene, M. I. (2021). FOXP3 and Tip60 Structural Interactions Relevant to IPEX Development Lead to Potential Therapeutics to Increase FOXP3 Dependent Suppressor T Cell Functions. Frontiers in pediatrics, vol. 9, p. 607292.
  8. Ma, T., Song, X., Piccirillo, C. A., Deng, G. & Greene, M. I. (2021). A Structure-Guided Delineation of FOXP3 Regulation Mechanism in IPEX. Advances in experimental medicine and biology, vol. 1278, p. 33-46.
  9. Mehdi, A., Attias, M., Mahmood, N., Arakelian, A., Mihalcioiu, C., Piccirillo, C. A., Szyf, M. & Rabbani, S. A. (2020). Enhanced Anticancer Effect of a Combination of S-adenosylmethionine (SAM) and Immune Checkpoint Inhibitor (ICPi) in a Syngeneic Mouse Model of Advanced Melanoma. Frontiers in oncology, vol. 10, p. 1361.
  10. Piccirillo, C. A. (2020). Transcriptional and translational control of Foxp3+ regulatory T cell functional adaptation to inflammation. Current opinion in immunology, vol. 67, p. 27-35.
More on PubMed 



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