Lab Information
Michael Reed (PhD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Tuberculosis (TB) • Mycobacterium tuberculosis • molecular microbiology • bacterial pathogenesis • antibiotic resistanceResearch Interests
The research of my laboratory focuses on molecular aspects of Mycobacterium tuberculosis (M. tuberculosis), the bacterial agent responsible for the human infectious disease, tuberculosis (TB). Despite the existence of effective anti-TB antibiotics and a partially effective vaccine (BCG) for more than half a century, TB still remains the cause of almost 2 million human deaths worldwide each year ─ the most due to any single infectious agent. M. tuberculosis also has the unenviable distinction of causing the most deaths as a result of antimicrobial resistance (AMR). Clearly, this situation reflects very poorly on our current level of understanding of the key molecular processes associated with pathogenesis and the acquisition of antibiotic resistance in this important global pathogen. Our laboratory combines molecular microbiology with cell-based and whole animal (mouse) infection models, in order to characterize a range of metabolic (e.g., cell signalling, gene regulation), virulence and antibiotic-resistance strategies that are available to this pathogen. Increasing our knowledge in these areas will greatly enhance future efforts aimed at developing novel antibiotic and/or vaccine-based approaches to prevent TB disease.Team Members
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Latest Publications
- Perera, D. J., Domenech, P., Babuadze, G. G., Naghibosadat, M., Alvarez, F., Koger-Pease, C., Labrie, L., Stuible, M., Durocher, Y., Piccirillo, C. A., Lametti, A., Fiset, P. O., Elahi, S. M., Kobinger, G. P., Gilbert, R., Olivier, M., Kozak, R., Reed, M. B. & Ndao, M. (2023). BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine. iScience, vol. 26, p. 107612.
- Domenech, P., Mouhoub, E. & Reed, M. B. (2022). Experimental Confirmation that an Uncommon rrs Gene Mutation (g878a) of Mycobacterium tuberculosis Confers Resistance to Streptomycin. Antimicrobial agents and chemotherapy, vol. 66, p. e0191521.
- Mouhoub, E., Domenech, P., Ndao, M. & Reed, M. B. (2021). The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview. Frontiers in microbiology, vol. 12, p. 757858.
- Ghanem, M., Dubé, J.-Y., Wang, J., McIntosh, F., Houle, D., Domenech, P., Reed, M. B., Raman, S., Buter, J., Minnaard, A. J., Moody, D. B. & Behr, M. A. (2020). Heterologous Production of 1-Tuberculosinyladenosine in Mycobacterium kansasii Models Pathoevolution towards the Transcellular Lifestyle of Mycobacterium tuberculosis. mBio, vol. 11.
- Buter, J., Cheng, T.-Y., Ghanem, M., Grootemaat, A. E., Raman, S., Feng, X., Plantijn, A. R., Ennis, T., Wang, J., Cotton, R. N., Layre, E., Ramnarine, A. K., Mayfield, J. A., Young, D. C., Jezek Martinot, A., Siddiqi, N., Wakabayashi, S., Botella, H., Calderon, R., Murray, M., Ehrt, S., Snider, B. B., Reed, M. B., Oldfield, E., Tan, S., Rubin, E. J., Behr, M. A., van der Wel, N. N., Minnaard, A. J. & Moody, D. B. (2019). Mycobacterium tuberculosis releases an antacid that remodels phagosomes. Nature chemical biology, vol. 15, p. 889-899.
- Vincent, A. T., Nyongesa, S., Morneau, I., Reed, M. B., Tocheva, E. I. & Veyrier, F. J. (2018). The Mycobacterial Cell Envelope: A Relict From the Past or the Result of Recent Evolution?. Frontiers in microbiology, vol. 9, p. 2341.
- Domenech, P., Zou, J., Averback, A., Syed, N., Curtis, D., Donato, S. & Reed, M. B. (2017). Unique Regulation of the DosR Regulon in the Beijing Lineage of Mycobacterium tuberculosis. Journal of bacteriology, vol. 199.
See also
