Lab Information
Michael Reed (PhD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Tuberculosis (TB) • Mycobacterium tuberculosis • molecular microbiology • bacterial pathogenesisResearch Interests
My research focuses on molecular aspects of the pathogenesis of Mycobacterium tuberculosis, the bacterial agent responsible for the infectious disease, tuberculosis (TB). Despite the existence of effective antibacterial drugs and a partially effective vaccine for more than half a century, TB still remains the cause of two million deaths worldwide each year. Although early studies considered TB strains to be restricted in terms of their genetic and antigenic variability, more recent evidence indicates that M. tuberculosis has evolved into several genetically diverse lineages of strains that are likely to possess unique attributes related to the transmission and development of disease. My laboratory utilizes a combination of microbial genetics, biochemistry and whole animal (mouse) in vivo infection studies to investigate the array of metabolic and virulence strategies available to this phenotypically diverse pathogen. Increasing our knowledge and understanding of this diversity will greatly enhance future efforts aimed at developing new strategies to successfully diagnose and treat TB disease.Team Members
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Latest Publications
- Perera, D. J., Domenech, P., Babuadze, G. G., Naghibosadat, M., Alvarez, F., Koger-Pease, C., Labrie, L., Stuible, M., Durocher, Y., Piccirillo, C. A., Lametti, A., Fiset, P. O., Elahi, S. M., Kobinger, G. P., Gilbert, R., Olivier, M., Kozak, R., Reed, M. B. & Ndao, M. (2023). BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine. iScience, vol. 26, p. 107612.
- Domenech, P., Mouhoub, E. & Reed, M. B. (2022). Experimental Confirmation that an Uncommon rrs Gene Mutation (g878a) of Mycobacterium tuberculosis Confers Resistance to Streptomycin. Antimicrobial agents and chemotherapy, vol. 66, p. e0191521.
- Mouhoub, E., Domenech, P., Ndao, M. & Reed, M. B. (2021). The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview. Frontiers in microbiology, vol. 12, p. 757858.
- Ghanem, M., Dubé, J.-Y., Wang, J., McIntosh, F., Houle, D., Domenech, P., Reed, M. B., Raman, S., Buter, J., Minnaard, A. J., Moody, D. B. & Behr, M. A. (2020). Heterologous Production of 1-Tuberculosinyladenosine in Mycobacterium kansasii Models Pathoevolution towards the Transcellular Lifestyle of Mycobacterium tuberculosis. mBio, vol. 11.
- Buter, J., Cheng, T.-Y., Ghanem, M., Grootemaat, A. E., Raman, S., Feng, X., Plantijn, A. R., Ennis, T., Wang, J., Cotton, R. N., Layre, E., Ramnarine, A. K., Mayfield, J. A., Young, D. C., Jezek Martinot, A., Siddiqi, N., Wakabayashi, S., Botella, H., Calderon, R., Murray, M., Ehrt, S., Snider, B. B., Reed, M. B., Oldfield, E., Tan, S., Rubin, E. J., Behr, M. A., van der Wel, N. N., Minnaard, A. J. & Moody, D. B. (2019). Mycobacterium tuberculosis releases an antacid that remodels phagosomes. Nature chemical biology, vol. 15, p. 889-899.
- Vincent, A. T., Nyongesa, S., Morneau, I., Reed, M. B., Tocheva, E. I. & Veyrier, F. J. (2018). The Mycobacterial Cell Envelope: A Relict From the Past or the Result of Recent Evolution?. Frontiers in microbiology, vol. 9, p. 2341.
- Domenech, P., Zou, J., Averback, A., Syed, N., Curtis, D., Donato, S. & Reed, M. B. (2017). Unique Regulation of the DosR Regulon in the Beijing Lineage of Mycobacterium tuberculosis. Journal of bacteriology, vol. 199.
See also
