Lab Information
Carolyn Jack (MD/PhD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Atopic dermatitis • NOD ligand • resident memory T cells • Staphylococcusaureus • T cellsResearch Interests
I am a dermatologist and PhD-trained immunologist with expertise in molecular biology, cellular immunology, immunophenotyping of primary human cells and tissues, in vitro human pre-clinical modeling of disease, and skin biospecimen-enabled clinical trials. My clinical work and research are focused on adult atopic dermatitis (AD), the most common and most burdensome skin disorder worldwide, affecting 5-10% of adults in developed countries. My research goal is to identify disease-modifying interventions in chronic AD. I have established the first Canadian disease-specific human skin and blood immunophenotyping lab, with a research program and immunophenotyping platform for investigating in situ and ex vivo mechanisms of chronic inflammation with adult AD patient skin, swabs, and blood. Patients are recruited from my specialized clinic, the Centre of Excellence for Atopic Dermatitis at the McGill University Health Centre, which is the first tertiary care centre in Canada dedicated to adult AD.Team Members
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Latest Publications
- Jack, C. & Drucker, A. M. (2024). Fears for tears? Targeted therapies for atopic dermatitis and ocular surface health. Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 38, p. 2053-2055.
- Jeremian, R., Malinowski, A., Oh, E. S., Gooderham, M., Sibbald, C., Yeung, J., Asai, Y., Piguet, V. & Jack, C. S. (2024). Epigenetic and biological age acceleration in children with atopic dermatitis. The journal of allergy and clinical immunology. Global, vol. 3, p. 100275.
- Jeremian, R., Lytvyn, Y., Fotovati, R., Li, K., Malinowski, A., Sachdeva, M., Jack, C., Gooderham, M., Croitoru, D. O., Yeung, J. & Piguet, V. (2024). Dysregulation of epigenetic, biological and mitotic age in the context of biologic drug treatment and phototherapy in plaque psoriasis patients. Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 38, p. e883-e886.
- Asiniwasis, R., Merati, N., Roesler, J., Simpson, E. L., Aubry, R., McMullen, E., Fraess, L., Choi, U. Y., Hinther, K., Chu, D. K. & Jack, C. (2024). 'The Social and Home Environment: Impacts of Determinants of Health on Atopic Dermatitis, Pathways Towards Solutions, and Unique Considerations for Rural and Remote North American Indigenous Populations'. The journal of allergy and clinical immunology. In practice, vol. 12, p. 290-299.
- Zuberbier, T., Abdul Latiff, A., Aggelidis, X., Augustin, M., Balan, R.-G., Bangert, C., Beck, L., Bieber, T., Bernstein, J. A., Bertolin Colilla, M., Berardi, A., Bedbrook, A., Bindslev-Jensen, C., Bousquet, J., de Bruin-Weller, M., Bruscky, D., Buyuktiryaki, B., Canonica, G. W., Castro, C., Chanturidze, N., Chong-Neto, H. J., Chu, C.-Y., Chularojanamontri, L., Cork, M., Criado, R. F. J., Barredo, L. C., Custovic, A., Darsow, U., Emurlai, A., de Pablo, A., Del Giacco, S., Girolomoni, G., Deleva Jovanova, T., Deleuran, M., Douladiris, N., Duarte, B., Dubakiene, R., Eller, E., Engel-Yeger, B., Ensina, L. F., Filho, N. R., Flohr, C., Fomina, D., Francuzik, W., Galimberti, M. L., Giménez-Arnau, A. M., Godse, K., Mortz, C. G., Gotua, M., Hide, M., Hoetzenecker, W., Hunzelmann, N., Irvine, A., Jack, C., Kanavarou, I., Katoh, N., Kinaciyan, T., Kocatürk, E., Kulthanan, K., Lapeere, H., Lau, S., Machado Forti Nastri, M., Makris, M., Mansour, E., Marsland, A., Morelo Rocha Felix, M., Moschione Castro, A. P., Nettis, E., Nicolas, J. F., Nosbaum, A., Odemyr, M., Papapostolou, N., Parisi, C. A. S., Paudel, S., Peter, J., Pokharel, P., Puig, L., Quint, T., Ramon, G. D., Regateiro, F., Ricci, G., Rosario, C., Sackesen, C., Schmid-Grendelmeier, P., Serra-Baldrich, E., Siemens, K., Smith, C., Staubach, P., Stevanovic, K., Su-Kücük, Ö., Sussman, G., Tavecchio, S., Teovska Mitrevska, N., Thaci, D., Toubi, E., Traidl-Hoffmann, C., Treudler, R., Vadasz, Z., van Hofman, I., Ventura, M. T., Wang, Z., Werfel, T., Wollenberg, A., Yang, A., Weng Yew, Y., Zhao, Z., Zwiener, R. & Worm, M. (2023). A concept for integrated care pathways for atopic dermatitis-A GA2 LEN ADCARE initiative. Clinical and translational allergy, vol. 13, p. e12299.
- Chatrath, S., LeBovidge, J., Jack, C., Abuabara, K., Schneider, L. C., Capozza, K., Kelley, K. & Silverberg, J. I. (2023). Mental Health Interventions for Atopic Dermatitis: Knowledge Gaps, Pilot Programs, and Future Directions. Clinical and experimental dermatology, vol. 49, p. 9-17.
- Yeung, J., Gooderham, M. J., Hong, H.-C., Lynde, C., Prajapati, V. H., Lansang, P., Turchin, I., Wiseman, M., Jack, C., Ramien, M., Purdy, K. & Grewal, P. (2023). Treat-to-target in the management of moderate-to-severe atopic dermatitis in adults: A Canadian perspective. Journal of the American Academy of Dermatology, vol. 89, p. 372-375.
- Gimenez-Rivera, V.-A., Patel, H., Dupuy, F. P., Allakhverdi, Z., Bouchard, C., Madrenas, J., Bissonnette, R., Piccirillo, C. A. & Jack, C. (2023). NOD2 Agonism Counter-Regulates Human Type 2 T Cell Functions in Peripheral Blood Mononuclear Cell Cultures: Implications for Atopic Dermatitis. Biomolecules, vol. 13.
- Adam, D. N., Gooderham, M. J., Beecker, J. R., Hong, C. H., Jack, C. S., Jain, V., Lansang, P., Lynde, C. W., Papp, K. A., Prajapati, V. H., Turchin, I. & Yeung, J. (2023). Expert consensus on the systemic treatment of atopic dermatitis in special populations. Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 37, p. 1135-1148.
- Ghazal, S., Ridha, Z., D'Aguanno, K., Nassim, D., Quaiattini, A., Netchiporouk, E., Poulin, Y., Kalia, S., Marcoux, D., Piguet, V. & Jack, C. (2022). Treatment Guidelines for Atopic Dermatitis Since the Approval of Dupilumab: A Systematic Review and Quality Appraisal Using AGREE-II. Frontiers in medicine, vol. 9, p. 821871.
