Information sur le laboratoire
Todd Lee (M.D.)
ScientifiqueUnité de recherche clinique
Département de médecine (McGill)
Profil de recherche
https://www.drtoddlee.com/
Mots-clés
Amélioration de la qualité • gestion de l'utilisation des antimicrobiens • résistance aux antibiotiques • essaies cliniques • polypharmacieIntérêts de recherche
Mes recherches portent sur la réalisation d'essais cliniques randomisés visant à améliorer le traitement des maladies infectieuses (par exemple, C. difficile, COVID-19, S. aureus, infections à Gram négatif) et à innover dans les domaines des soins de patients hospitalisés complexes, des soins des adultes plus âgés atteints de polypharmacie, et de la gérance des ressources en soins de santé (par exemple, les tests et les médicaments).Membre de l'équipe
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Dernières publications
- Prosty, C., Carignan, A., Chan, A. K., Chen, Y., Daley, P., Daneman, N., Kandel, C., Longtin, Y., Perez-Patrigeon, S., Wuerz, T., Cheaveau, J., Hota, S. S., Ogundipe, O., Steiner, T. S., Tsang, J. L. Y., Archambault, P., Bergevin, M., Brophy, J. M., Girouard, G., Kong, L., Parkes, L., Reinblatt, S., MacFadden, D., Lee, T. C. & McDonald, E. G. (2026). Secondary Prophylaxis of Recurrent Clostridioides difficile Infections During Systemic Antibiotics with Vancomycin (SPORES-V): study protocol for a randomized controlled trial. Trials.
- Filosa, E., Schönenberger, N., Essien, U. R., Gagnon, C., Gnjidic, D., Kouladjian O'Donnell, L., Manias, E., McCarthy, L. M., Moriarty, F., Nguyen-Soenen, J., Scott, S., Steinman, M. A., Thürmann, P. A., Wilson, M. G., Gutman, B. J., Mendel, A., Trinh, E., Lee, T. C. & McDonald, E. G. (2026). Identification of Potentially Inappropriate Medications for Adults Below 65 Years: Protocol for a Modified Delphi Study. JMIR research protocols, vol. 15, p. e92082.
- Goodman, A. L., Easom, N., Bielopolski, D., Sutherland, R. K., Marks, M., Hensgens, M. P. M., Bonten, M., Bostock, J., Walls, G., Lye, D., Boyles, T., Yahav, D., Cheng, M. P., Legg, A., Paul, M., Lescure, F.-X., Lee, T. C., Tong, S. Y. C. & Davis, J. S. (2026). A review of the randomized clinical trial results from the Staphylococcus aureus network adaptive platform (SNAP) meticillin-susceptible (MSSA) and penicillin-susceptible (PSSA) domains and CloCeBa. The Journal of antimicrobial chemotherapy, vol. 81.
- Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group, Lee, T. C., Barina, L. A., Walls, G., Goodman, A. L., Yahav, D., Cheng, M. P., Bonten, M., Bowen, A. C., Boyles, T., Daneman, N., Ekkelenkamp, M. B., Ghanem-Zoubi, N., Hensgens, M. P. M., Jager, N. G. L., Kaasch, A. J., Kouijzer, I. J. E., Lewis, R. J., Lumley, T., Lye, D. C., McDonald, E. G., McKew, G., McLean, A. R. D., McMullan, B. J., McQuilten, Z. K., Morpeth, S. C., Paterson, D. L., Roberts, J. A., Robinson, J. O., Saito, H., Scarborough, M., Ten Oever, J., Turner, R. M., Tverring, J., van Hal, S. J., Webb, S. A., Whiteway, L. M., Arias, C. A., Henderson, A., Heriot, G. S., Snelling, T. L., Afra, K., Ali, S. S., Amit, S., Anagnostou, N. A., Archuleta, S., Aston, S. J., Athan, E., Baharav, N., Bai, A. D., Barber, B. E., Baskaran, A., Berkeley, M. M. A., Best, E. J., Bhilave, N. R., Bloomfield, M. G., Bond, K. A., Bostock, J., Botheras, C. L., Boyd, M. A., Bradshaw, S. M. E., Briggs, E. J., Britton, P. N., Campbell, A. J., Carr, B. Z., Chancellor, J. A., Chen, K., Cheong, E. Y., Chew, K. L., Chia, P. Y., Chomba, R., Chong, B. S. W., Clews, C. J. N., Cohen, J. M., Commons, R. J., Cutfield, T., Daley, P., Daniel, D. S., Davies, J., De, P., Denholm, J. T., Di Virgilio, M., Dishon-Benattar, Y., Dotel, R., Duan, E. H., Easom, N., Eliakim-Raz, N., England, M. M., Fahmy, M., Findlater, A. R., Flanagan, K. L., Foo, E. Z. J., Foo, H., Forster, D. P., Fralick, M., Frazer, J. L., Gador-Whyte, A. P., Garnham, K., German, G. J., Ghosh, N., Gisolf, E. H., Giulieri, S. G., Goulding, S. R., Grant, J. M., Gregson, D., Grimwade, K. C., Grupper, M., Guy, S. D., Gwee, A., Hall, V. G., Hardy, E. J., Harris, D. J., Hatcher, J., Hobbs, M. R., Holmes, N. E., Howden, B. P., Huggan, P. J., Jennings, Z. A., Johnstone, J., Juniper, T., Kalimuddin, S., Kamfose, M., Kandel, C., Kelly, M. J., Kozak, R. A., Kümin, M., Lamontagne, F., Lau, J. S. Y., Lee, I. R., Lin, R. J., Lindsay, D., Llewelyn, M. J., Longtin, Y., Lother, S. A., Luey, C. E., MacFadden, D. R., Mahony, A. A., Malden, C., Malhamé, I., Manning, L. A., Marks, M., Martin, L. J., Matthews, G. V., McGann, P. H., McMahon, J. H., Melon, A., Menon, V., Mertz, D., Meyer, M. P., Molton, J. S., Mora, J. M., Moran, E., Mortimer, L. M., Motaganahalli, S., Muller, M. P., Munro, A. P. S., Murray, F. A., Murthy, S., Nagendra, V., Nel, H., New, D. W. J., Nguyen, V., Norton, G., Norton, K. M., Nourse, C. B., Nye, C. J. S., O'Callaghan, K., O'Sullivan, M. V. N., Ong, S. W. X., Otu, A. A., Owen, M., Papenburg, J., Parkes, L. O., Paul, M., Perez-Patrigeon, S., Petersiel, N., Petrella, L., Pett, S. L., Pham, D., Piazzese, C. J., Poulin, S., Rehak, R., Rennert-May, E., Richards, A. J., Rogers, B. A., Sahng, E., Salada, B., Scheuerman, O., Schneider, K., Schulz, T. R., Schwartz, K. L., Simos, P. A., Singh, H., Sinkeler, F. S., Smith, S., Smith, B. J., Smith, S. W., Somayaji, R., Sommerville, C., Song, R. X. J., Sowden, D. C., Stark, M. J., Stone, N. R. H., Strunk, T., Sud, A., Swe, K. P., Symons, C. R., Tan, Y. E., Ten Doesschate, T., Thien, S. Y., Thomas, A., Trad, M.-A., Tramontana, A. R., Tsang, J. L. Y., Ulett, K., Underwood, J., van Welzen, B. J., Vazquez-Grande, G., Velasquez Reyes, D. C., Verberk, J. D. M., Voss, L. M., Ward, D., Webb, R. H., Whitmore, T. J., Wieder-Finesod, A., Wilson, H. L., Wilson, E. W., Wong, H. M., Wong She, K., Wuerz, T., Yamamura, D. L., Yeoh, A., Yow, B. L. H., Dymock, M., Mahar, R. K., McGlothlin, A., Marsh, J. A., Davis, J. S. & Tong, S. Y. C. (2026). Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia. The New England journal of medicine, vol. 394, p. 2329-2339.
- Hamani, M., Pinto, R., Lee, T. C., MacFadden, D., McDonald, E. G., Sligl, W., Fowler, R. A., Daneman, N. & BALANCE consortium (2026). Duration of antibiotic therapy for bacteraemia in immune compromised hosts-a post-hoc subgroup analysis of the Bacteremia Antibiotic Length Actually Needed For Clinical Effectiveness (BALANCE) randomized clinical trial. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
- Lasry, D., Harrison, L. B., Bamba, R., Corsini, R., Yansouni, C. P., Cheng, M. P., Lee, T. C. & Lawandi, A. (2026). In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces Pseudomonas aeruginosa resistance to antipseudomonal antibiotics (APA). The Journal of antimicrobial chemotherapy, vol. 81.
- Harrison, L. B., Sohani, Z. N., Lasry, D., Cheng, M. P., Lee, T. C., Babiker, A., Kadri, S. S. & Lawandi, A. (2026). Rapid Microbiological Diagnostics for Sepsis: Narrative Review of Current and Prospective Approaches. Critical care explorations, vol. 8, p. e1415.
- Cabanilla, M. G., Ghanem, B., Jegorović, B., Lee, T. C., Chahine, E. B., Anderson, D. T., Salgado, N. K., Eudy, J., Singh, H. K., Muyidi, A. A., Astorri, R., Maraolo, A. E., Antolí Royo, A. C., Mena Lora, A. J., Pimentel, B. V. & Spellberg, B. (2026). Universal high-dose meropenem for antimicrobial-resistant Gram-negative infections: evidence or overreach?. European journal of hospital pharmacy : science and practice.
- Prosty, C., Desormeau, B., Lee, T. C. & McDonald, E. G. (2026). Diagnosis, treatment, and prophylaxis of Clostridioides difficile infections: A cross-sectional survey of Canadian clinicians. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 11, p. 37-50.
- Hamilton, F., Lee, T. C., Davey Smith, G., Hartwig, F. P. & Butler-Laporte, G. (2026). The illusion of causality: Instruments, colliders, and acute kidney injury in sepsis. American journal of respiratory and critical care medicine.
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