Information sur le laboratoire
Todd Lee (M.D.)
ScientifiqueUnité de recherche clinique
Département de médecine (McGill)
Profil de recherche
https://www.drtoddlee.com/
Mots-clés
Amélioration de la qualité • gestion de l'utilisation des antimicrobiens • résistance aux antibiotiques • essaies cliniques • polypharmacieIntérêts de recherche
Mes recherches portent sur la réalisation d'essais cliniques randomisés visant à améliorer le traitement des maladies infectieuses (par exemple, C. difficile, COVID-19, S. aureus, infections à Gram négatif) et à innover dans les domaines des soins de patients hospitalisés complexes, des soins des adultes plus âgés atteints de polypharmacie, et de la gérance des ressources en soins de santé (par exemple, les tests et les médicaments).Membre de l'équipe
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Dernières publications
- Cabanilla, M. G., Ghanem, B., Jegorović, B., Lee, T. C., Chahine, E. B., Anderson, D. T., Salgado, N. K., Eudy, J., Singh, H. K., Muyidi, A. A., Astorri, R., Maraolo, A. E., Antolí Royo, A. C., Mena Lora, A. J., Pimentel, B. V. & Spellberg, B. (2026). Universal high-dose meropenem for antimicrobial-resistant Gram-negative infections: evidence or overreach?. European journal of hospital pharmacy : science and practice.
- Prosty, C., Desormeau, B., Lee, T. C. & McDonald, E. G. (2026). Diagnosis, treatment, and prophylaxis of Clostridioides difficile infections: A cross-sectional survey of Canadian clinicians. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 11, p. 37-50.
- Hamilton, F., Lee, T. C., Davey Smith, G., Hartwig, F. P. & Butler-Laporte, G. (2026). The illusion of causality: Instruments, colliders, and acute kidney injury in sepsis. American journal of respiratory and critical care medicine.
- Ross, S. B., Bortolussi-Courval, É., Juhásová, Z., Weir, D. L., Wilson, A. G., Lee, T. C., McDonald, E. G. & Wilson, M. G. (2026). Measuring Medication Related Harm: Proposed Guidance for Adverse Drug Event Adjudication to Harmonize Outcomes in Deprescribing Research. Journal of the American Geriatrics Society.
- Shechtman, L., Murthy, S., Tremblay, A., Silverman, M., Lee, T. C., Daley, P., Pinto, R., Fowler, R. A. & Canadian Treatments for COVID-19 (CATCO) investigators, the Association of Medical Microbiology and Infectious Disease Canada (AMMI) Clinical Research Network, and the Canadian Critical Care Trials Group (2025). Extended-duration dexamethasone for the treatment of hospitalized COVID-19 patients in Canada: A randomized clinical trial. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 10, p. 299-303.
- Butler, C. C., Pinto, A. D., Harris, V., Holmes, J., Rahman, N. M., Cureton, L., Hayward, G., Richards, D. B., Lowe, D. M., Standing, J. F., Breuer, J., Hood, K., Png, M. E., Petrou, S., Dorward, J., Patel, M. G., Thomas, N. P. B., Evans, P., Hart, N. D., Jani, B. D., Hosseini, B., Murthy, S., McBrien, K., Condon, A., McDonald, E. G., Daley, P., Greiver, M., da Costa, B. R., Selby, P., Jüni, P., Lee, T. C., Shi, H., Detry, M. A., Saunders, C. T., Fitzgerald, M., Berry, N. S., Saville, B. R., Khoo, S. H., Nguyen-Van-Tam, J. S., Hobbs, F. D. R., Yu, L.-M., Little, P. & PANORAMIC Trial and CanTreatCOVID Trial Collaborative Groups (2026). Oral Nirmatrelvir-Ritonavir for Covid-19 in Higher-Risk Outpatients. The New England journal of medicine, vol. 394, p. 1583-1594.
- Spellberg, B., Ghanem, B., Morante-Ruiz, M., Bortolussi-Courval, É., Makam, A. N., Ergenc, Z., Riccardi, N., Meyer-Sautter, P., Alharbi, S., Rocha-Pereira, N., Centor, R. M., Ryder, J., Bhoojhawon, G., Ahmed, I., Cabanilla, M. G., Almeida, F., Pimentel, B. V., Starkey, J., Costa, R. P. L., Maraolo, A. E., Tong, S. Y. C., Anderson, D. T., Murri, R., McDonald, E. G. & Lee, T. C. (2026). Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS-IDSA Debate. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Hosseini, B., Condon, A., da Costa, B. R., Daley, P., Greiver, M., Jüni, P., Lee, T. C., McBrien, K., McDonald, E. G., Murthy, S., Selby, P. & Pinto, A. D. (2026). Lessons learned and recommendations from the Canadian adaptive platform trial of treatments for COVID in community settings (CanTreatCOVID). Contemporary clinical trials, vol. 165, p. 108303.
- Yahav, D., Pinto, R., Cook, D., Davis, J., Duan, E., Hoffman, T., Lee, T. C., McDonald, E. G., Morpeth, S., Muscedere, J., Sligl, W., Wuerz, T., Fowler, R. A., Daneman, N. & BALANCE consortium (2026). Duration of therapy for Pseudomonas aeruginosa bacteremia - a post hoc subgroup analysis from the BALANCE randomized controlled trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- McDonald, E. G., Butler-Laporte, G., Brophy, J. M., Elsayed, S., Frenette, C., Huseen, I., Loo, V. G., Moran, K., Coburn, B., Hota, S. S., Longtin, Y., Kong, L. Y., Muller, M. P., Steiner, T. S., Valiquette, L., Daneman, N., Daley, P., Nott, C., MacFadden, D. R., Kandel, C. E., Chen, Y., Perez-Patrigeon, S., Lee, T. C. & TAPER-V Team (2026). Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial. JAMA network open, vol. 9, p. e2560495.
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