Information sur le laboratoire
Matthew Cheng (M.D.)
ScientifiqueCentre de biologie translationnelle
Département de médecine (McGill)
Profil de recherche
Mots-clés
Maladies infectieuses mortelles • infections opportunistes • septicémie • bactériémieIntérêts de recherche
Mes recherches portent sur les patients atteints d'infections potentiellement mortelles, notamment ceux qui présentent des manifestations graves de septicémie, d'infections du sang et d'infections opportunistes chez les hôtes immunodéprimés. Mon programme de recherche vise à améliorer la morbidité et la mortalité dans ces conditions en découvrant des stratégies de traitement originales grâce à des essais cliniques avant-gardistes. Je développe également de nouveaux tests de diagnostic pour améliorer les résultats chez ces patients, comme l'utilisation d'ADN sans cellules plasmatiques pour surveiller la réponse de l'hôte à l'infection et optimiser les décisions de traitement.Membre de l'équipe
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Dernières publications
- Mellett, M., Van Riel, J., Corsini, R., Satola, S., Lawandi, A., Caya, C., van Hal, S., Lee, T. C., Papenburg, J., Yansouni, C. P., Babiker, A. & Cheng, M. P. (2025). The combinations of cefazolin with linezolid and cefazolin with clindamycin are indifferent against methicillin-susceptible Staphylococcus aureus. Microbiology spectrum, p. e0176325.
- Walls, G., McGrath, L., Herdman, M. T., Campbell, A. J., Cheng, M. P., Marks, M., Oever, J. T., Sahng, E., Yahav, D., Tong, S. Y. C., Goodman, A. L., Lim, A. G., Bloomfield, M. & Staphylococcus aureus Network Adaptive Platform Trial Early Oral Switch Domain Specific Working Group (2025). Patient-reported perceptions, experiences and preferences around intravenous and oral antibiotics for the treatment of Staphylococcus aureus bacteremia: a descriptive qualitative study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Tadount, F., Boivin, G., Longtin, Y., Savard, P., Cheng, M. P., Decaluwe, H., De Serres, G., Fortin, É. & Quach, C. (2025). Is COVID-19 Associated With an Increased Risk of Subsequent Upper Respiratory Tract Infections in Adults? A Prospective Cohort Study. Open forum infectious diseases, vol. 12, p. ofaf544.
- Boodman, C., Cimen, C., Yansouni, C. P. & Cheng, M. P. (2025). Culture Clash: Dual-Pathogen Endocarditis and the Metagenomic Next Generation Sequencing Studies We Need. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Mzava, O., Agun, G. F., Loy, C. J., Gonzalez-Bocco, I. H., Kounatse, L.-D., Bliss, A., Wells, S. L., Lenz, J., Belcher, E., Chen, K., Koo, S., Baden, L. R., Chu, T., Cheng, M. P., Ritz, J., Gupta, S. & De Vlaminck, I. (2025). Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications. Clinical chemistry, vol. 71, p. 1058-1066.
- Cheng, M. P., Gonzalez-Bocco, I. H., Arbonna-Haddad, E., Aleissa, M., Chen, K., Zhou, E., Beluch, K., Cho, A., Burchett, S., Moulton, E., Desjardins, M., Baden, L. R., Koo, S., Letourneau, A. R., Hammond, S. P., Ritz, J., Soiffer, R., Issa, N. C., Kim, H. T. & Sherman, A. C. (2025). Letermovir Treatment for Refractory or Resistant Cytomegalovirus Infection or Disease or with Concurrent Organ Dysfunction: A Phase 2 Open Label Study. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 10, p. 6-14.
- Lasry, D., Lee, T. C., Paquette, K., Demir, K., Yansouni, C., Sweet, D., Cheng, M. P. & Lawandi, A. (2024). Canadian Antibiotic Prescribing for Sepsis (CAPS) Study: A Post Hoc Analysis of the FABLED Cohort Study. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 9, p. 239-248.
- Hadid, A., McDonald, E. G., Ding, Q., Phillipp, C., Trottier, A., Dixon, P. C., Jlassi, O., Cheng, M. P., Papenburg, J., Libman, M. & Jensen, D. (2025). Development of machine learning prediction models for systemic inflammatory response following controlled exposure to a live attenuated influenza vaccine in healthy adults using multimodal wearable biosensors in Canada: a single-centre, prospective controlled trial. The Lancet. Digital health, p. 100886.
- Mellett, M., Lawandi, A., Caya, C., Lee, T. C., Babiker, A., Papenburg, J., Yansouni, C. P. & Cheng, M. P. (2025). Antibiotic synergy against Staphylococcus aureus: a systematic review and meta-analysis. Antimicrobial agents and chemotherapy, p. e0119924.
- Chen, G. S., Lee, T., Tsang, J. L. Y., Binnie, A., McCarthy, A., Cowan, J., Archambault, P., Lellouche, F., Turgeon, A. F., Yoon, J., Lamontagne, F., McGeer, A., Douglas, J., Daley, P., Fowler, R., Maslove, D. M., Winston, B. W., Lee, T. C., Tran, K. C., Cheng, M. P., Vinh, D. C., Boyd, J. H., Walley, K. R., Singer, J., Marshall, J. C., Russell, J. A. & Community-Acquired Pneumonia: Toward InnoVAtive Treatment (CAPTIVATE) Investigators (2025). Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia. Critical care explorations, vol. 7, p. e1262.
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