Lab Information

Christos Tsoukas (MD/MSc)

Senior Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 50%
 Clinical: 50%
 Epidemiology: 0%
 Evaluation: 0%
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Immune risk phenotype • inflammation • biomarkers • cardiovascular • immunopathology • cohort studies • T cell activation • primary immune deficiency

Research Interests

My research focuses on the interplay of HIV-associated chronic inflammation, immune activation, and accelerated aging. The risk of having medical conditions that are more frequently found in the elderly, such as heart disease, stroke, osteoporosis and dementia may relate to the premature aging of the immune system. I am currently conducting two large clinical studies of healthy Canadians and those with HIV to define the biological age of individuals as opposed to numerical age. Understanding immune parameters related to biological age may provide insight on why coronary artery disease may occur earlier in those with chronic inflammatory diseases.

Team Members

Name Position

Latest Publications

  1. AlOtaibi, I., Almuhizi, F., Ton-Leclerc, S., Fein, M., Tsoukas, C., Garvey, L. H., Lee, D., Ben-Shoshan, M., Isabwe, G. A. C. & Copaescu, A. M. (2023). Anaphylaxis induced by mRNA COVID-19 vaccines: follow-up and booster dose after previous desensitization. Frontiers in allergy, vol. 4, p. 1056619.
  2. Alenazy, L. A., Hinther, K., AlMuhizi, F., Fein, M., Tsoukas, C., Ben-Shoshan, M., Copaescu, A. M. & Isabwe, G. A. C. (2022). Tolerance of the mRNA COVID-19 vaccines in patients with reported taxane reactions. The journal of allergy and clinical immunology. In practice, vol. 10, p. 2169-2171.e2.
  3. ALMuhizi, F., Fein, M., Gabrielli, S., Gilbert, L., Tsoukas, C., Ben-Shoshan, M., Copaescu, A. M. & Isabwe, G. A. C. (2022). Allergic reactions to the coronavirus disease 2019 vaccine (ARCOV) study: The McGill University Health Centre experience. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, vol. 129, p. 182-188.e1.
  4. AlMuhizi, F., Ton-Leclerc, S., Fein, M., Tsoukas, C., Garvey, L. H., Lee, D., Ben-Shoshan, M., Isabwe, G. A. C. & Copaescu, A. M. (2022). Successful Desensitization to mRNA COVID-19 Vaccine in a Case Series of Patients With a History of Anaphylaxis to the First Vaccine Dose. Frontiers in allergy, vol. 3, p. 825164.
  5. Kabir, A., Alizadehfar, R. & Tsoukas, C. M. (2021). Good's Syndrome: Time to Move on From Reviewing the Past. Frontiers in immunology, vol. 12, p. 815710.
  6. Yero, A., Shi, T., Farnos, O., Routy, J.-P., Tremblay, C., Durand, M., Tsoukas, C., Costiniuk, C. T. & Jenabian, M.-A. (2021). Dynamics and epigenetic signature of regulatory T-cells following antiretroviral therapy initiation in acute HIV infection. EBioMedicine, vol. 71, p. 103570.
  7. Poloni, C., Szyf, M., Cheishvili, D. & Tsoukas, C. M. (2022). Are the Healthy Vulnerable? Cytomegalovirus Seropositivity in Healthy Adults Is Associated With Accelerated Epigenetic Age and Immune Dysregulation. The Journal of infectious diseases, vol. 225, p. 443-452.
  8. Alsulami, K., Bolastig, N., Dupuy, F. P., Mabanga, T., Gilbert, L., Kiani, Z., Routy, J.-P., Bruneau, J., Thomas, R., Tremblay, C., Tsoukas, C. M., Szabo, J., Côté, P., Trottier, B., LeBlanc, R., Rouleau, D., Bernard, N. F. & investigators in the Montreal Primary HIV Infection cohort (2021). Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point. Journal of virology, vol. 95, p. e0041721.
  9. Fehr, D., Lebouché, B., Ruppenthal, L., Brownc, M., Obasc, N., Bourbonnière, E., Girouard, J., Massicotte, A., Jenabian, M.-A., Almomen, A.-A., Frenette, C., de Pokomandy, A., Cox, J., Giannakis, A., Cheng, M., Kronfli, N., Tsoukas, C., Zahedi, N., Szabo, J., Dehghani, K., Brouillette, M.-J., Falutz, J., Turner, H., Hamel, A., Duchesneau, C., Lanthier-Brun, J., Klein, M., Routy, J.-P. & Costiniuk, C. T. (2022). Characterization of people living with HIV in a Montreal-based tertiary care center with COVID-19 during the first wave of the pandemic. AIDS care, vol. 34, p. 663-669.
  10. Rothan, C., Yero, A., Shi, T., Farnos, O., Chartrand-Lefebvre, C., El-Far, M., Costiniuk, C. T., Tsoukas, C., Tremblay, C., Durand, M., Jenabian, M.-A. & Canadian HIV and Aging Cohort Study (2021). Antiretroviral therapy-treated HIV-infected adults with coronary artery disease are characterized by a distinctive regulatory T-cell signature. AIDS (London, England), vol. 35, p. 1003-1014.
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