Lab Information
Matthew Cheng (MD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Lethal infectious diseases • opportunistic infections • sepsis • bacteremiaResearch Interests
My research focuses on patients with potentially lethal infections, including those with severe manifestations of sepsis, bloodstream infections, and opportunistic infections in immunocompromised hosts. My research program aims to improve morbidity and mortality in these conditions by discovering original treatment strategies through avant-garde clinical trials. I also develop novel diagnostic assays to improve outcomes in these patients, such as using plasma cell-free DNA to monitor the host response to infection and optimize treatment decisions.Team Members
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Latest Publications
- Mellett, M., Van Riel, J., Corsini, R., Satola, S., Lawandi, A., Caya, C., van Hal, S., Lee, T. C., Papenburg, J., Yansouni, C. P., Babiker, A. & Cheng, M. P. (2025). The combinations of cefazolin with linezolid and cefazolin with clindamycin are indifferent against methicillin-susceptible Staphylococcus aureus. Microbiology spectrum, p. e0176325.
- Walls, G., McGrath, L., Herdman, M. T., Campbell, A. J., Cheng, M. P., Marks, M., Oever, J. T., Sahng, E., Yahav, D., Tong, S. Y. C., Goodman, A. L., Lim, A. G., Bloomfield, M. & Staphylococcus aureus Network Adaptive Platform Trial Early Oral Switch Domain Specific Working Group (2025). Patient-reported perceptions, experiences and preferences around intravenous and oral antibiotics for the treatment of Staphylococcus aureus bacteremia: a descriptive qualitative study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Tadount, F., Boivin, G., Longtin, Y., Savard, P., Cheng, M. P., Decaluwe, H., De Serres, G., Fortin, É. & Quach, C. (2025). Is COVID-19 Associated With an Increased Risk of Subsequent Upper Respiratory Tract Infections in Adults? A Prospective Cohort Study. Open forum infectious diseases, vol. 12, p. ofaf544.
- Boodman, C., Cimen, C., Yansouni, C. P. & Cheng, M. P. (2025). Culture Clash: Dual-Pathogen Endocarditis and the Metagenomic Next Generation Sequencing Studies We Need. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Mzava, O., Agun, G. F., Loy, C. J., Gonzalez-Bocco, I. H., Kounatse, L.-D., Bliss, A., Wells, S. L., Lenz, J., Belcher, E., Chen, K., Koo, S., Baden, L. R., Chu, T., Cheng, M. P., Ritz, J., Gupta, S. & De Vlaminck, I. (2025). Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications. Clinical chemistry, vol. 71, p. 1058-1066.
- Cheng, M. P., Gonzalez-Bocco, I. H., Arbonna-Haddad, E., Aleissa, M., Chen, K., Zhou, E., Beluch, K., Cho, A., Burchett, S., Moulton, E., Desjardins, M., Baden, L. R., Koo, S., Letourneau, A. R., Hammond, S. P., Ritz, J., Soiffer, R., Issa, N. C., Kim, H. T. & Sherman, A. C. (2025). Letermovir Treatment for Refractory or Resistant Cytomegalovirus Infection or Disease or with Concurrent Organ Dysfunction: A Phase 2 Open Label Study. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 10, p. 6-14.
- Lasry, D., Lee, T. C., Paquette, K., Demir, K., Yansouni, C., Sweet, D., Cheng, M. P. & Lawandi, A. (2024). Canadian Antibiotic Prescribing for Sepsis (CAPS) Study: A Post Hoc Analysis of the FABLED Cohort Study. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 9, p. 239-248.
- Hadid, A., McDonald, E. G., Ding, Q., Phillipp, C., Trottier, A., Dixon, P. C., Jlassi, O., Cheng, M. P., Papenburg, J., Libman, M. & Jensen, D. (2025). Development of machine learning prediction models for systemic inflammatory response following controlled exposure to a live attenuated influenza vaccine in healthy adults using multimodal wearable biosensors in Canada: a single-centre, prospective controlled trial. The Lancet. Digital health, p. 100886.
- Mellett, M., Lawandi, A., Caya, C., Lee, T. C., Babiker, A., Papenburg, J., Yansouni, C. P. & Cheng, M. P. (2025). Antibiotic synergy against Staphylococcus aureus: a systematic review and meta-analysis. Antimicrobial agents and chemotherapy, p. e0119924.
- Chen, G. S., Lee, T., Tsang, J. L. Y., Binnie, A., McCarthy, A., Cowan, J., Archambault, P., Lellouche, F., Turgeon, A. F., Yoon, J., Lamontagne, F., McGeer, A., Douglas, J., Daley, P., Fowler, R., Maslove, D. M., Winston, B. W., Lee, T. C., Tran, K. C., Cheng, M. P., Vinh, D. C., Boyd, J. H., Walley, K. R., Singer, J., Marshall, J. C., Russell, J. A. & Community-Acquired Pneumonia: Toward InnoVAtive Treatment (CAPTIVATE) Investigators (2025). Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia. Critical care explorations, vol. 7, p. e1262.
See also
