Lab Information
Jean-Pierre Routy (MD)
Senior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
HIV • chronic viral infections • CMV • HHV8 • HIV reservoirs • gutResearch Interests
My research focuses on human immunodeficiency virus (HIV) pathogenesis aiming at finding an HIV cure. Improving knowledge in immune tolerance in cancer and immunometabolism will be key to developing strategy to conquer cancers and auto-immune diseases.Team Members
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Latest Publications
- Santangelo, M., Bendoumou, M., Dutilleul, A., Khalfi, S., Plant, E., Ngassaki-Yoka, C. D., Pilosio, L., Vanhulle, C., Dias, J., Marray, T., Fattaccioli, A., Verhasselt, B., Lange, U., Dieu, M., Routy, J.-P., Rohr, O., Renard, P., Ancuta, P. & VAN Lint, C. (2026). Identification of the cellular factor KLF16 as a novel epigenetic repressor of HIV-1 transcription. Research square.
- Moreira Gabriel, E., Moreaux, J., Kaofai, C., Majidi Ivari, K., Schmouth, J.-F., Goulet, J.-P., Dias, J., Wiche Salinas, T. R., Raymond Marchand, L., Khalfi, S., Routy, J.-P., Durand, M., El-Far, M., Tremblay, C. L. & Ancuta, P. (2026). Pharmacological and genetic modulation of IL-32 expression in intestinal epithelial cells does not impact HIV-1 outgrowth in co-cultured CD4+ T-cells. Frontiers in immunology, vol. 17, p. 1769388.
- Rong, Y., Lambertucci, F., Yang, Y., Carbonnier, V., Chen, H., Dong, Y., Mingoia, S., Li, S., Motiño, O., Montégut, L., Joseph, A., Ferret, L., Saavedra Díaz, E. G., Isnard, S., Routy, J.-P., Djavaheri-Mergny, M., Castedo, M., Fuerlinger, A., Abdellatif, M., Maiuri, M. C., Martins, I. & Kroemer, G. (2026). Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation. Cell death and differentiation.
- Cinque, F., Nudo, M., Saeed, S., Lim, J., Kablawi, D., Mariano, G., Lupu, A., Elgretli, W., Moodie, E. E. M., Price, C., Monteith, K., Cooper, C., Walmsley, S., Kronfli, N., Cox, J., Costiniuk, C., De Pokomandy, A., Routy, J.-P., Klein, M. B., Lebouche, B. & Sebastiani, G. (2026). Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Impaired Health-Related Quality of Life in People With HIV. Gastro hep advances, vol. 5, p. 100966.
- Santangelo, M., Bendoumou, M., Dutilleul, A., Khalfi, S., Plant, E., Ngassaki-Yoka, C. D., Pilosio, L., Vanhulle, C., Dias, J., Marray, T., Fattaccioli, A., Dieu, M., Routy, J.-P., Rohr, O., Renard, P., Ancuta, P. & VAN Lint, C. (2026). Identification of the cellular transcription factor KLF16 as a novel repressive epigenetic repressor of HIV-1 transcription. bioRxiv : the preprint server for biology.
- Al-Abdulmalek, A., Isnard, S., Watters, A. A. & Routy, J.-P. (2026). From suspected brain malignancy to Erdheim-Chester disease: the role of PET imaging and bone marrow biopsy in diagnosis. Oxford medical case reports, vol. 2026, p. omag049.
- Meissner, E. G., Ramgopal, M., Ruane, P. J., Sanchez, W., Crofoot, G., Routy, J.-P., Brinson, C., DeJesus, E., Martorell, C. T., Tellez, M., Yokomaku, Y., O'Reilly, M., Lupo, S., Schellberg, S., Lezama-Mora, J. I., Chin, B., Aizen, K., D'Antoni, M. L., Huang, H., Mponponsuo, K., Montezuma-Rusca, J. M., Sklar, P., Rhee, M., Hung, C.-C. & ARTISTRY-2 Study Group (2026). Safety and efficacy of switching to bictegravir-lenacapavir versus continuing bictegravir-emtricitabine-tenofovir alafenamide in virologically suppressed people with HIV-1 (ARTISTRY-2): a double-blind, multicentre, randomised, controlled, phase 3, non-inferiority trial. The lancet. HIV.
- Fava, V. M., Dallmann-Sauer, M., Orlova, M., Correa-Macedo, W., Olivenstein, R., Costiniuk, C. T., Routy, J.-P., Barreiro, L. B. & Schurr, E. (2026). Continuous antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages. Frontiers in immunology, vol. 17, p. 1805936.
- Al-Abdulmalek, A., Landry, E., Abdulgayoom, M., Al-Mashdali, A. F., Dalol, A. A., Muthanna, B., Routy, J.-P. & Mohamed, S. F. (2026). BRAF Alterations in Chronic Lymphocytic Leukemia: Genomic Landscape, Co-Mutation Patterns, and Clinical Relevance. Current hematologic malignancy reports, vol. 21.
- Luo, Y. H., Zuberi, N., Rizzolo, A., Warner, M., Isnard, S. & Routy, J.-P. (2026). Stroke From Paradoxical Embolism in a Young Patient With Sickle-Cell Disease and High Fetal Hemoglobin: A Diagnostic Challenge. Clinical case reports, vol. 14, p. e72618.
See also
