Lab Information
Ana Copaescu (MD/PhD)
InvestigatorClinical Research Unit
Department of Medicine (McGill)
Research Profile
Keywords
Immune-mediated adverse drug reactions • severe cutaneous adverse reaction • point-of-care solutions • risk stratification tools • in vivo diagnostic tools • ex vivo diagnostic tools • clinical trialsResearch Interests
My research focuses on drug allergy−related pathologies, including their clinical identification, diagnostic methods and management. The ongoing clinical and translational research projects aim to improve precision diagnosis, including mechanisms to remove drug allergy labels and develop diagnostic tools. Additionally, I aim to advance our understanding of the complex, severe, delayed drug reactions associated with significant acute and long-term morbidity and mortality. These developments allow me to be part of a network of international collaborators, an excellent platform for exchanging and developing new projects. Addressing the significant health issue of immune-mediated drug allergy will lead to high-level research output that will translate into improvement in healthcare, locally and internationally.Team Members
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Latest Publications
- Stehlin, F., Prosty, C., Mulé, A., Al-Otaibi, I., Colli, L. D., Gaffar, J., Yu, J., Lanoue, D., Copaescu, A.-M. & Ben-Shoshan, M. (2024). Guiding drug provocation testing for ibuprofen hypersensitivity in a pediatric population: Development of the I3A risk-stratification tool. The journal of allergy and clinical immunology. In practice.
- Copaescu, A. M., Mak, H. W. F., Vogrin, S., Holmes, N. E., Trubiano, J. A. & Li, P. H. (2025). Global differences and risk factors influencing drug hypersensitivity quality of life: A multicenter, multiethnic study of drug allergy across 3 continents. The journal of allergy and clinical immunology. Global, vol. 4, p. 100354.
- ALOtaibi, I., Khoudja, R. Y., Isabwe, G. A. C., Fein, M., Stehlin, F., James, F., Ben-Shoshan, M., Trubiano, J. A. & Copaescu, A. M. (2024). Tolerance of penicillin V in patients with confirmed delayed hypersensitivity reactions to aminopenicillins. The journal of allergy and clinical immunology. In practice.
- Sillcox, C., Gabrielli, S., O'Keefe, A., McCusker, C., Abrams, E. M., Eiwegger, T., Atkinson, A., Kim, V., Copaescu, A.-M. & Ben-Shoshan, M. (2024). Evaluating Pediatric Macrolide Allergy Using Direct Graded Oral Challenges. JAMA pediatrics, vol. 178, p. 1362-1364.
- Copaescu, A. M., Vogrin, S., Mouhtouris, E., Chua, K. Y., Holmes, N. E. & Trubiano, J. A. (2024). A multicentre comparative cohort study of severe maculopapular exanthema and drug reaction with eosinophilia and systematic symptoms. The journal of allergy and clinical immunology. In practice, vol. 12, p. 3442-3445.e2.
- Copaescu, A. M., Vogrin, S., Douglas, A., Turner, N. A., Phillips, E. J., Holmes, N. E. & Trubiano, J. A. (2024). Risk of Self-Reported Penicillin Allergy Despite Removal of Penicillin Allergy Label: Secondary Analysis of the PALACE Randomized Clinical Trial. JAMA network open, vol. 7, p. e2429621.
- Barbaud, A., Goncalo, M., Mockenhaupt, M., Copaescu, A. & Phillips, E. J. (2024). Delayed skin testing for systemic medications: helpful or not?. The journal of allergy and clinical immunology. In practice, vol. 12, p. 2268-2277.
- Copaescu, A. M. & Trubiano, J. A. (2024). Optimizing How We Measure Quality of Life in Drug Hypersensitivity. The journal of allergy and clinical immunology. In practice, vol. 12, p. 1592-1593.
- Stehlin, F., Khoudja, R. Y., Lee, D., Toupin, J.-F., Isabwe, G. A. C., Fein, M., Al-Otaibi, I., Phillips, E. J., Trubiano, J. A. & Copaescu, A.-M. (2024). Skin testing and challenge in patients with immediate hypersensitivity reactions to gadolinium-based contrast agents identify safe future options. Allergology international : official journal of the Japanese Society of Allergology, vol. 73, p. 610-614.
- Copaescu, A. M., Li, L., Blumenthal, K. G. & Trubiano, J. A. (2024). How to Define and Manage Low-Risk Drug Allergy Labels. The journal of allergy and clinical immunology. In practice, vol. 12, p. 1095-1106.
