Information sur le laboratoire
Jean-Pierre Routy (M.D.)
Scientifique séniorCentre de biologie translationnelle
Département de médecine (McGill)
Profil de recherche
Mots-clés
VIH • Infections virales chroniques • CMV • HHV8 • Réservoirs du VIH • IntestinIntérêts de recherche
Mes recherches portent sur la pathogenèse du virus de l'immunodéficience humaine (VIH), dans le but de trouver un traitement contre cette maladie. L'amélioration des connaissances sur la tolérance immunitaire dans le cancer et l'immunométabolisme sera essentielle à l'élaboration d'une stratégie visant à vaincre les cancers et les maladies auto-immunes.Membre de l'équipe
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Dernières publications
- Santangelo, M., Bendoumou, M., Dutilleul, A., Khalfi, S., Plant, E., Ngassaki-Yoka, C. D., Pilosio, L., Vanhulle, C., Dias, J., Marray, T., Fattaccioli, A., Verhasselt, B., Lange, U., Dieu, M., Routy, J.-P., Rohr, O., Renard, P., Ancuta, P. & VAN Lint, C. (2026). Identification of the cellular factor KLF16 as a novel epigenetic repressor of HIV-1 transcription. Research square.
- Moreira Gabriel, E., Moreaux, J., Kaofai, C., Majidi Ivari, K., Schmouth, J.-F., Goulet, J.-P., Dias, J., Wiche Salinas, T. R., Raymond Marchand, L., Khalfi, S., Routy, J.-P., Durand, M., El-Far, M., Tremblay, C. L. & Ancuta, P. (2026). Pharmacological and genetic modulation of IL-32 expression in intestinal epithelial cells does not impact HIV-1 outgrowth in co-cultured CD4+ T-cells. Frontiers in immunology, vol. 17, p. 1769388.
- Rong, Y., Lambertucci, F., Yang, Y., Carbonnier, V., Chen, H., Dong, Y., Mingoia, S., Li, S., Motiño, O., Montégut, L., Joseph, A., Ferret, L., Saavedra Díaz, E. G., Isnard, S., Routy, J.-P., Djavaheri-Mergny, M., Castedo, M., Fuerlinger, A., Abdellatif, M., Maiuri, M. C., Martins, I. & Kroemer, G. (2026). Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation. Cell death and differentiation.
- Cinque, F., Nudo, M., Saeed, S., Lim, J., Kablawi, D., Mariano, G., Lupu, A., Elgretli, W., Moodie, E. E. M., Price, C., Monteith, K., Cooper, C., Walmsley, S., Kronfli, N., Cox, J., Costiniuk, C., De Pokomandy, A., Routy, J.-P., Klein, M. B., Lebouche, B. & Sebastiani, G. (2026). Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Impaired Health-Related Quality of Life in People With HIV. Gastro hep advances, vol. 5, p. 100966.
- Santangelo, M., Bendoumou, M., Dutilleul, A., Khalfi, S., Plant, E., Ngassaki-Yoka, C. D., Pilosio, L., Vanhulle, C., Dias, J., Marray, T., Fattaccioli, A., Dieu, M., Routy, J.-P., Rohr, O., Renard, P., Ancuta, P. & VAN Lint, C. (2026). Identification of the cellular transcription factor KLF16 as a novel repressive epigenetic repressor of HIV-1 transcription. bioRxiv : the preprint server for biology.
- Al-Abdulmalek, A., Isnard, S., Watters, A. A. & Routy, J.-P. (2026). From suspected brain malignancy to Erdheim-Chester disease: the role of PET imaging and bone marrow biopsy in diagnosis. Oxford medical case reports, vol. 2026, p. omag049.
- Meissner, E. G., Ramgopal, M., Ruane, P. J., Sanchez, W., Crofoot, G., Routy, J.-P., Brinson, C., DeJesus, E., Martorell, C. T., Tellez, M., Yokomaku, Y., O'Reilly, M., Lupo, S., Schellberg, S., Lezama-Mora, J. I., Chin, B., Aizen, K., D'Antoni, M. L., Huang, H., Mponponsuo, K., Montezuma-Rusca, J. M., Sklar, P., Rhee, M., Hung, C.-C. & ARTISTRY-2 Study Group (2026). Safety and efficacy of switching to bictegravir-lenacapavir versus continuing bictegravir-emtricitabine-tenofovir alafenamide in virologically suppressed people with HIV-1 (ARTISTRY-2): a double-blind, multicentre, randomised, controlled, phase 3, non-inferiority trial. The lancet. HIV.
- Fava, V. M., Dallmann-Sauer, M., Orlova, M., Correa-Macedo, W., Olivenstein, R., Costiniuk, C. T., Routy, J.-P., Barreiro, L. B. & Schurr, E. (2026). Continuous antiretroviral therapy induces progressive senescence-like reprogramming of alveolar macrophages. Frontiers in immunology, vol. 17, p. 1805936.
- Al-Abdulmalek, A., Landry, E., Abdulgayoom, M., Al-Mashdali, A. F., Dalol, A. A., Muthanna, B., Routy, J.-P. & Mohamed, S. F. (2026). BRAF Alterations in Chronic Lymphocytic Leukemia: Genomic Landscape, Co-Mutation Patterns, and Clinical Relevance. Current hematologic malignancy reports, vol. 21.
- Luo, Y. H., Zuberi, N., Rizzolo, A., Warner, M., Isnard, S. & Routy, J.-P. (2026). Stroke From Paradoxical Embolism in a Young Patient With Sickle-Cell Disease and High Fetal Hemoglobin: A Diagnostic Challenge. Clinical case reports, vol. 14, p. e72618.
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