Lab Information
Joyce Rauch (PhD)
Senior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Autoimmunity • systemic lupus erythematosus • autoantibodies • T cells • cell deathResearch Interests
My research focuses on systemic lupus erythematosus (SLE), which is an autoimmune disease affecting approximately one in every 1000 Canadian women, and often causing chronic pain and premature death. Individuals with SLE develop an immune response against their own cells, but it is unclear why this response develops. We hypothesize that cells in SLE-prone individuals die in a manner that causes them to appear foreign, thus resulting in an immune response to these cells. We will use an induced model of SLE to determine whether injecting cells that have died in different ways can produce SLE autoantibodies in mice. We will also evaluate whether inhibiting different types of cell death in mice that develop SLE-like disease spontaneously can prevent autoantibody production and disease. Our research will identify the role of different forms of cell death in the development of SLE, and how modifying cell death may produce or prevent SLE.Team Members
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Latest Publications
- Juillard, S., Karakeussian-Rimbaud, A., Normand, M.-H., Turgeon, J., Veilleux-Trinh, C., C Robitaille, A., Rauch, J., Chruscinski, A., Grandvaux, N., Boilard, É., Hébert, M.-J. & Dieudé, M. (2024). Vascular injury derived apoptotic exosome-like vesicles trigger autoimmunity. Journal of translational autoimmunity, vol. 9, p. 100250.
- Kmeťová, K., Lonina, E., Yalavarthi, S., Levine, J. S., Hoy, C. K., Sarosh, C., Gockman, K., Morris, A. E., Tambralli, A., Madison, J. A., Zuo, Y., Subang, R., Rauch, J. & Knight, J. S. (2023). Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps. Clinical immunology (Orlando, Fla.), p. 109714.
- Rivera, C. R., Srisuwananukorn, A., Bajwa, R. J., Gordeuk, V. R., Rauch, J., Levine, J. S. & Saraf, S. L. (2023). Predictors and clinical complications associated with antiphospholipid antibodies in sickle cell disease. EJHaem, vol. 4, p. 211-215.
- Mendel, A., Fritzler, M. J., St-Pierre, Y., Rauch, J., Bernatsky, S. & Vinet, É. (2023). Outcomes associated with antiphospholipid antibodies in COVID-19: A prospective cohort study. Research and practice in thrombosis and haemostasis, vol. 7, p. 100041.
- de França, N. R., Ménard, H. A., Lora, M., Zhou, Z., Rauch, J., Hitchon, C., Andrade, L. E. C. & Colmegna, I. (2022). Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis. Arthritis research & therapy, vol. 24, p. 23.
- Melki, I., Allaeys, I., Tessandier, N., Mailhot, B., Cloutier, N., Campbell, R. A., Rowley, J. W., Salem, D., Zufferey, A., Laroche, A., Lévesque, T., Patey, N., Rauch, J., Lood, C., Droit, A., McKenzie, S. E., Machlus, K. R., Rondina, M. T., Lacroix, S., Fortin, P. R. & Boilard, E. (2020). FcγRIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus. Blood, vol. 136, p. 2933-2945.
- Salem, D., Subang, R., Pernet, E., Divangahi, M., Pineau, C., Cayrol, R., Levine, J. S. & Rauch, J. (2019). Necroptotic cell binding of β2 -glycoprotein I provides a potential autoantigenic stimulus in systemic lupus erythematosus. Immunology and cell biology, vol. 97, p. 799-814.
- Becker, Y., Marcoux, G., Allaeys, I., Julien, A.-S., Loignon, R.-C., Benk-Fortin, H., Rollet-Labelle, E., Rauch, J., Fortin, P. R. & Boilard, E. (2019). Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA. Frontiers in immunology, vol. 10, p. 1026.
- Becker, Y., Loignon, R.-C., Julien, A.-S., Marcoux, G., Allaeys, I., Lévesque, T., Rollet-Labelle, E., Benk-Fortin, H., Cloutier, N., Melki, I., Eder, L., Wagner, É., Pelletier, M., Hajj, H. E., Tremblay, M.-È., Belleannée, C., Hébert, M.-J., Dieudé, M., Rauch, J., Fortin, P. R. & Boilard, E. (2019). Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations. Scientific reports, vol. 9, p. 4530.
- Rauch, J., Salem, D., Subang, R., Kuwana, M. & Levine, J. S. (2018). β2-Glycoprotein I-Reactive T Cells in Autoimmune Disease. Frontiers in immunology, vol. 9, p. 2836.
See also
