Lab Information

Christian Pineau (MD)

Investigator
Clinical Research Unit
Department of Medicine (McGill)

Research Profile

 Fundamental: 10%
 Clinical: 60%
 Epidemiology: 20%
 Evaluation: 10%
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Keywords

Lupus • morbidity • cardiovascular disease • vasculitis • adherence to treatment • prognostic factors

Research Interests

My research focuses on defining and limiting the burden of cardiovascular disease and non-vascular cardiac diseases in SLE. Aside from conducting research to delineate the extent to which SLE patients suffer from sequelae of the disease (both related to cardiac and other morbidities), I have actively pursued strategies aimed at preventing cardiac disease in the systemic lupus patients that are served by the Montreal General Hospital Lupus Clinic. This has included focusing more attention on potentially reversible risk factors for cardiac disease, such as hypertension, cholesterol, antiphospholipid antibodies, and homocysteine. To the practice of annual assessments of SLE patients for general health issues, I have advocated for and successfully introduced the yearly systematic evaluation of some of these particular cardiac risk factors.


Team Members

Name Position

Latest Publications

  1. Desmarais, J., Rosenbaum, J. T., Costenbader, K. H., Ginzler, E. M., Fett, N., Goodman, S., O'Dell, J., Pineau, C. A., Schmajuk, G., Werth, V. P., Link, M. S. & Kovacs, R. (2022). Letter to the Editor Reply Regarding ACR White Paper on Antimalarials and Cardiac Toxicity: Suggested Amendments to Future Directions. Arthritis & rheumatology (Hoboken, N.J.), vol. 74, p. 1301.
  2. Barbacki, A., Rached-d'Astous, N., Pineau, C. A., Vinet, E., Grenier, L.-P., Kalache, F., Fallavollita, S., Lukusa, L. & Bernatsky, S. (2022). Clinical Significance of Raynaud Phenomenon in Systemic Lupus Erythematosus. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, vol. 28, p. e488-e490.
  3. Zhao, N., Al-Aly, Z., Zheng, B., van Donkelaar, A., Martin, R. V., Pineau, C. A. & Bernatsky, S. (2021). Fine particles matter components and interstitial lung disease in rheumatoid arthritis. The European respiratory journal.
  4. Liu, J. L., Pineau, C. A., Grenier, L.-P., Vinet, E., Kalache, F., Lukusa, L. & Bernatsky, S. (2021). Treatment patterns and control of hypertension in systemic lupus erythematosus (SLE): a cross-sectional study. BMJ open, vol. 11, p. e048384.
  5. Desmarais, J., Rosenbaum, J. T., Costenbader, K. H., Ginzler, E. M., Fett, N., Goodman, S., O'Dell, J., Pineau, C. A., Schmajuk, G., Werth, V. P., Link, M. S. & Kovacs, R. (2021). American College of Rheumatology White Paper on Antimalarial Cardiac Toxicity. Arthritis & rheumatology (Hoboken, N.J.), vol. 73, p. 2151-2160.
  6. Zheng, B., Soares de Moura, C., Machado, M., Pineau, C. A., Curtis, J. R., Vinet, E. & Bernatsky, S. (2021). Association between chronic obstructive pulmonary disease, smoking, and interstitial lung disease onset in rheumatoid arthritis. Clinical and experimental rheumatology.
  7. Lambert-Fliszar, F., Bernatsky, S., Kalache, F., Grenier, L.-P., Pineau, C. A. & Vinet, E. (2021). Personalised therapy during preconception and gestation in SLE: usefulness of 6-mercaptopurine metabolite levelswith azathioprine. Lupus science & medicine, vol. 8.
  8. Cotton, T., Niaki, O. Z., Zheng, B., Pineau, C. A., Fritzler, M., Vinet, E., Clarke, A. E. & Bernatsky, S. (2021). Myositis in systemic lupus erythematosus. Lupus, vol. 30, p. 615-619.
  9. Almeida-Brasil, C. C., Pineau, C. A., Vinet, E., Hanly, J. G., Peschken, C. A., Clarke, A. E., Fortin, P. R., Abrahamowicz, M. & Bernatsky, S. (2020). Predictors of unsuccessful hydroxychloroquine tapering and discontinuation: Can we personalize decision-making in systemic lupus treatment?. Arthritis care & research.
  10. Dominguez, D., Kamphuis, S., Beyene, J., Wither, J., Harley, J. B., Blanco, I., Vila-Inda, C., Brunner, H., Klein-Gitleman, M., McCurdy, D., Wahezi, D. M., Lehman, T., Jelusic, M., Peschken, C. A., Pope, J. E., Gladman, D. D., Hanly, J. G., Clarke, A. E., Bernatsky, S., Pineau, C., Smith, C. D., Barr, S., Boire, G., Rich, E., Silverman, E. D. & Canadian Network for Improved Outcomes in SLE (CaNIOS) and APPLE Investigators (2021). Relationship Between Genetic Risk and Age of Diagnosis in Systemic Lupus Erythematosus. The Journal of rheumatology, vol. 48, p. 852-858.
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