Lab Information
Martin Olivier (PhD)
Senior ScientistCentre for Translational Biology
Department of Microbiology & Immunology (McGill)
Research Profile
Keywords
Leishmaniasis • malaria • exosome • innate inflammation • signalingResearch Interests
My research focuses on understanding how pathogens can evade the host immune response by manipulating the biochemical cascades involved in the regulation of phagocyte microbicidal functions. My pathogens of interest are protozoan parasites causing malaria, which causes up to two millions deaths annually, and leishmaniasis, which affects more than 250 million individuals worldwide. I have found that leishmania can tame the innate inflammatory response of the host, using its surface protease that can also be contained in microvesicules rapidly released within the host environment. For Malaria, my research revealed that a crystalline metabolic waste (HZ) of the parasite was responsible for a great number of inflammation-related pathologies encountered during this important infection. My lab's findings may lead to the development of new therapies against those infectious agents, which could be applied to others such as tuberculosis. They might also lead to the development of new diagnostic tools based on exo-biomarkers, and potentially to vaccine development.Team Members
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Latest Publications
- Leroux, M., Lafleur, A., Villalba-Guerrero, C., Beaulieu, M., Lira, A. B. & Olivier, M. (2024). Extracellular vesicles in parasitic protozoa: Impact of Leishmania exosomes containing Leishmania RNA virus 1 (LRV1) on Leishmania infectivity and disease progression. Current topics in membranes, vol. 94, p. 157-186.
- da Silva Lira Filho, A., Lafleur, A., Alvarez, F., Piccirillo, C. A. & Olivier, M. (2024). Implication of the Annexin 1/FPR axis in leishmanial exosome-mediated Leishmania major skin hyperpathogenesis. Frontiers in immunology, vol. 15, p. 1436151.
- Fernandez-Becerra, C., Xander, P., Alfandari, D., Dong, G., Aparici-Herraiz, I., Rosenhek-Goldian, I., Shokouhy, M., Gualdron-Lopez, M., Lozano, N., Cortes-Serra, N., Karam, P. A., Meneghetti, P., Madeira, R. P., Porat, Z., Soares, R. P., Costa, A. O., Rafati, S., da Silva, A.-C., Santarém, N., Fernandez-Prada, C., Ramirez, M. I., Bernal, D., Marcilla, A., Pereira-Chioccola, V. L., Alves, L. R., Portillo, H. D., Regev-Rudzki, N., de Almeida, I. C., Schenkman, S., Olivier, M. & Torrecilhas, A. C. (2023). Guidelines for the purification and characterization of extracellular vesicles of parasites. Journal of extracellular biology, vol. 2, p. e117.
- Siddiq, A., Dong, G., Balan, B., Harrison, L. G., Jex, A., Olivier, M., Allain, T. & Buret, A. G. (2023). A thermo-resistant and RNase-sensitive cargo from Giardia duodenalis extracellular vesicles modifies the behaviour of enterobacteria. Journal of extracellular biology, vol. 2, p. e109.
- Carvalho Cabral, P., Richard, V. R., Borchers, C. H., Olivier, M. & Cermakian, N. (2024). Circadian Control of the Response of Macrophages to Plasmodium Spp.-Infected Red Blood Cells. ImmunoHorizons, vol. 8, p. 442-456.
- Carvalho Cabral, P., Stegeman, S. K., Olivier, M. & Cermakian, N. (2024). Circadian Regulation of Leishmania Parasite Internalisation in Macrophages and Downstream Cellular Events. Parasite immunology, vol. 46, p. e13053.
- Carrera Páez, L. C., Olivier, M., Gambino, A. S., Poklepovich, T., Aguilar, A. P., Quiroga, M. P. & Centrón, D. (2024). Sporadic clone Escherichia coli ST615 as a vector and reservoir for dissemination of crucial antimicrobial resistance genes. Frontiers in cellular and infection microbiology, vol. 14, p. 1368622.
- Carvalho Cabral, P., Weinerman, J., Olivier, M. & Cermakian, N. (2024). Time of day and circadian disruption influence host response and parasite growth in a mouse model of cerebral malaria. iScience, vol. 27, p. 109684.
- Tandoh, K. Z., Ibarra-Meneses, A. V., Langlais, D., Olivier, M., Torrecilhas, A. C., Fernandez-Prada, C., Regev-Rudzki, N. & Duah-Quashie, N. O. (2024). Extracellular Vesicles: Translational Agenda Questions for Three Protozoan Parasites. Traffic (Copenhagen, Denmark), vol. 25, p. e12935.
- Boy-Waxman, S., Olivier, M. & Cermakian, N. (2024). Clockwork intruders: Do parasites manipulate their hosts' circadian rhythms?. Current research in parasitology & vector-borne diseases, vol. 5, p. 100171.
