Lab Information
Martin Olivier (PhD)
Senior ScientistCentre for Translational Biology
Department of Microbiology & Immunology (McGill)
Keywords
Leishmaniasis • malaria • exosome • innate inflammation • signalingResearch Interests
My research focuses on understanding how pathogens can evade the host immune response by manipulating the biochemical cascades involved in the regulation of phagocyte microbicidal functions. My pathogens of interest are protozoan parasites causing malaria, which causes up to two millions deaths annually, and leishmaniasis, which affects more than 250 million individuals worldwide. I have found that leishmania can tame the innate inflammatory response of the host, using its surface protease that can also be contained in microvesicules rapidly released within the host environment. For Malaria, my research revealed that a crystalline metabolic waste (HZ) of the parasite was responsible for a great number of inflammation-related pathologies encountered during this important infection. My lab's findings may lead to the development of new therapies against those infectious agents, which could be applied to others such as tuberculosis. They might also lead to the development of new diagnostic tools based on exo-biomarkers, and potentially to vaccine development.Team Members
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Latest Publications
- Tandoh, K. Z., Ibarra-Meneses, A. V., Langlais, D., Olivier, M., Torrecilhas, A. C., Fernandez-Prada, C., Regev-Rudzki, N. & Duah-Quashie, N. O. (2024). Extracellular Vesicles: Translational Agenda Questions for Three Protozoan Parasites. Traffic (Copenhagen, Denmark), vol. 25, p. e12935.
- Boy-Waxman, S., Olivier, M. & Cermakian, N. (2024). Clockwork intruders: Do parasites manipulate their hosts' circadian rhythms?. Current research in parasitology & vector-borne diseases, vol. 5, p. 100171.
- da Silva Lira Filho, A., Lafleur, A., Marcet-Palacios, M. & Olivier, M. (2024). Identification of potential novel proteomic markers of Leishmania spp.-derived exosomes. Frontiers in cellular and infection microbiology, vol. 14, p. 1354636.
- Vucetic, A., Lafleur, A., Côté, M., Kobasa, D., Chan, M., Alvarez, F., Piccirillo, C., Dong, G. & Olivier, M. (2023). Extracellular vesicle storm during the course of Ebola virus infection in primates. Frontiers in cellular and infection microbiology, vol. 13, p. 1275277.
- Nguyen, A. M. T., Shalev-Benami, M., Rosa-Teijeiro, C., Ibarra-Meneses, A. V., Yonath, A., Bashan, A., Jaffe, C. L., Olivier, M., Fernandez-Prada, C. & Lubell, W. D. (2023). Systematic Exploration of Functional Group Relevance for Anti-Leishmanial Activity of Anisomycin. Biomedicines, vol. 11.
- Perera, D. J., Domenech, P., Babuadze, G. G., Naghibosadat, M., Alvarez, F., Koger-Pease, C., Labrie, L., Stuible, M., Durocher, Y., Piccirillo, C. A., Lametti, A., Fiset, P. O., Elahi, S. M., Kobinger, G. P., Gilbert, R., Olivier, M., Kozak, R., Reed, M. B. & Ndao, M. (2023). BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine. iScience, vol. 26, p. 107612.
- Vialard, F., Allaeys, I., Dong, G., Phan, M. P., Singh, U., Hébert, M. J., Dieudé, M., Langlais, D., Boilard, E., Labbé, D. P. & Olivier, M. (2023). Thermoneutrality and severe malaria: investigating the effect of warmer environmental temperatures on the inflammatory response and disease progression. Frontiers in immunology, vol. 14, p. 1128466.
- Alvarez, F., Istomine, R., Da Silva Lira Filho, A., Al-Aubodah, T.-A., Huang, D., Okde, R., Olivier, M., Fritz, J. H. & Piccirillo, C. A. (2023). IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections. Mucosal immunology, vol. 16, p. 462-475.
- Ibarra-Meneses, A. V., Amin, A., Dong, G., Olivier, M., Langlais, D. & Fernandez-Prada, C. (2023). Identification and analysis of the DNA content of small extracellular vesicles isolated from Leishmania parasites. STAR protocols, vol. 4, p. 102248.
- Dagenais, A., Villalba-Guerrero, C. & Olivier, M. (2023). Trained immunity: A "new" weapon in the fight against infectious diseases. Frontiers in immunology, vol. 14, p. 1147476.