Lab Information
Alexander Lawandi (MD/MSc)
Junior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Adaptive antimicrobial resistance bacteriology • life threatening infections • critical care • proteomicsResearch Interests
My research is focused upon studying bacterial pathogens associated with life-threatening infections, particularly in the critically ill. We utilize proteomic approaches (both shotgun and targeted) to study how these pathogens adapt to antibacterial therapies being administered. Our goals are to characterize adaptations that may reduce therapeutic efficacy, and similarly, to understand how the pathogens modulate their virulence factors to cause disease. We further study post-translational modifications in bacteria to understand how they may be involved in the coordinated response to antibiotics with the aim of describing potential new drug targets.Team Members
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Latest Publications
- Babiker, A., Warner, S., Li, X., Chishti, E. A., Saad, E., Swihart, B. J., Dekker, J. P., Walker, M., Lawandi, A., Kadri, S. S. & NIH-Antimicrobial Resistance Outcomes Research Initiative (2024). Adjunctive linezolid versus clindamycin for toxin inhibition in β-lactam-treated patients with invasive group A streptococcal infections in 195 US hospitals from 2016 to 2021: a retrospective cohort study with target trial emulation. The Lancet. Infectious diseases.
- Roussel, L., Bernier, S., Perez, A., Sun, Y., Angers, I., Laneuville, P., Lawandi, A. & Vinh, D. C. (2024). Impaired apoptosis underlying lymphoproliferative disease in a patient with haploinsufficient NFKB1 deficiency. British journal of haematology, vol. 205, p. 2089-2093.
- Rhee, C., Chen, T., Kadri, S. S., Lawandi, A., Yek, C., Walker, M., Warner, S., Fram, D., Chen, H.-C., Shappell, C. N., DelloStritto, L., Klompas, M. & CDC Prevention Epicenters Program (2024). Trends in Empiric Broad-Spectrum Antibiotic Use for Suspected Community-Onset Sepsis in US Hospitals. JAMA network open, vol. 7, p. e2418923.
- Lieu, A., Harrison, L. B., Harel, J., Lawandi, A., Cheng, M. P. & Domingo, M.--. C. (2024). The microbiological outcomes of culture-negative blood specimens using 16S rRNA broad-range PCR sequencing: a retrospective study in a Canadian province from 2018 to 2022. Journal of clinical microbiology, vol. 62, p. e0151823.
- Lawandi, A., Oshiro, M., Warner, S., Diao, G., Strich, J. R., Babiker, A., Rhee, C., Klompas, M., Danner, R. L. & Kadri, S. S. (2024). The authors reply. Critical care medicine, vol. 52, p. e31-e33.
- Lieu, A., Lee, T. C., Lawandi, A., Tellier, R., Cheng, M. P. & Dufresne, P. J. (2023). Microbiological characterization of Pneumocystis jirovecii pneumonia using quantitative PCR from nasopharyngeal specimens: a retrospective study in a Canadian province from 2019 to 2023. Journal of clinical microbiology, p. e0091323.
- Del Corpo, O., Senécal, J., Hsu, J. M., Lawandi, A. & Lee, T. C. (2023). Rapid phenotypic testing for detection of carbapenemase- or extended spectrum ß-lactamase-producing Enterobacterales directly from blood cultures: A systematic review and meta-analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 29, p. 1516-1527.
- Lawandi, A. (2023). Bloodstream Infections in Sepsis: Better the Devil You Know. Critical care medicine, vol. 51, p. 1261-1263.
- Cheng, M. P., Paquette, K., Lawandi, A., Stabler, S. N., Akhter, M., Davidson, A. C., Gavric, M., Jinah, R., Saeed, Z., Demir, K., Sangsari, S., Huang, K., Mahpour, A., Shamatutu, C., Caya, C., Troquet, J.-M., Clark, G., Rush, B., Wong, T., Stenstrom, R., Sweet, D. & Yansouni, C. P. (2022). qSOFA does not predict bacteremia in patients with severe manifestations of sepsis. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 7, p. 364-368.
- Lawandi, A., Oshiro, M., Warner, S., Diao, G., Strich, J. R., Babiker, A., Rhee, C., Klompas, M., Danner, R. L. & Kadri, S. S. (2023). Reliability of Admission Procalcitonin Testing for Capturing Bacteremia Across the Sepsis Spectrum: Real-World Utilization and Performance Characteristics, 65 U.S. Hospitals, 2008-2017. Critical care medicine, vol. 51, p. 1527-1537.
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