Lab Information
Alexander Lawandi (MD/MSc)
Junior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Adaptive antimicrobial resistance bacteriology • life threatening infections • critical care • proteomicsResearch Interests
My research is focused upon studying bacterial pathogens associated with life-threatening infections, particularly in the critically ill. We utilize proteomic approaches (both shotgun and targeted) to study how these pathogens adapt to antibacterial therapies being administered. Our goals are to characterize adaptations that may reduce therapeutic efficacy, and similarly, to understand how the pathogens modulate their virulence factors to cause disease. We further study post-translational modifications in bacteria to understand how they may be involved in the coordinated response to antibiotics with the aim of describing potential new drug targets.Team Members
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Latest Publications
- Lasry, D., Harrison, L. B., Bamba, R., Corsini, R., Yansouni, C. P., Cheng, M. P., Lee, T. C. & Lawandi, A. (2026). In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces Pseudomonas aeruginosa resistance to antipseudomonal antibiotics (APA). The Journal of antimicrobial chemotherapy, vol. 81.
- Harrison, L. B., Sohani, Z. N., Lasry, D., Cheng, M. P., Lee, T. C., Babiker, A., Kadri, S. S. & Lawandi, A. (2026). Rapid Microbiological Diagnostics for Sepsis: Narrative Review of Current and Prospective Approaches. Critical care explorations, vol. 8, p. e1415.
- Thivierge-Southidara, M. & Lawandi, A. (2026). Lower Respiratory Tract Infections: Precision Diagnostics. Critical care clinics, vol. 42, p. 537-561.
- Mellett, M., Van Riel, J., Corsini, R., Satola, S., Lawandi, A., Caya, C., van Hal, S., Lee, T. C., Papenburg, J., Yansouni, C. P., Babiker, A. & Cheng, M. P. (2025). The combinations of cefazolin with linezolid and cefazolin with clindamycin are indifferent against methicillin-susceptible Staphylococcus aureus. Microbiology spectrum, p. e0176325.
- Lasry, D., Lee, T. C., Paquette, K., Demir, K., Yansouni, C., Sweet, D., Cheng, M. P. & Lawandi, A. (2024). Canadian Antibiotic Prescribing for Sepsis (CAPS) Study: A Post Hoc Analysis of the FABLED Cohort Study. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 9, p. 239-248.
- Lee, T. C., Albuquerque, A. M., Lawandi, A., Prosty, C. J., Kotani, Y., Landoni, G. & McDonald, E. G. (2026). Systemic Corticosteroids Continue to Reduce Mortality in Severe Community-Acquired Pneumonia: An Updated Meta-Analysis. Journal of general internal medicine, vol. 41, p. 239-241.
- Mellett, M., Lawandi, A., Caya, C., Lee, T. C., Babiker, A., Papenburg, J., Yansouni, C. P. & Cheng, M. P. (2025). Antibiotic synergy against Staphylococcus aureus: a systematic review and meta-analysis. Antimicrobial agents and chemotherapy, p. e0119924.
- Sohani, Z. N., Lieu, A., Semret, M., Cheng, M. P., Simic, N., Bamba, R., Patel, M., Lawandi, A. & Lee, T. C. (2025). Comparison of ciprofloxacin and aminoglycoside susceptibility testing for ceftriaxone non-susceptible Enterobacterales by disk diffusion and VITEK 2 vs. broth microdilution using updated Clinical and Laboratory Standards Institute breakpoints. BMC microbiology, vol. 25, p. 175.
- Prosty, C., Katergi, K., Papenburg, J., Lawandi, A., Lee, T. C., Shi, H., Burnham, P., Swem, L., Routy, B., Yansouni, C. P. & Cheng, M. P. (2024). Causal role of the gut microbiome in certain human diseases: a narrative review. eGastroenterology, vol. 2, p. e100086.
- Lawandi, A., Kadri, S. S. & Powers, J. H. (2023). Focusing on antimicrobial resistant infections -are we missing the forest for the trees and the patients for pathogens?. Frontiers in antibiotics, vol. 2, p. 1329081.
See also
