Lab Information
Matthieu Allez (MD/PhD)
InvestigatorClinical Research Unit
Department of Medicine (McGill)
Research Profile
Keywords
Translational IBD research • gene expression • T cell repertoire • multiomic analysis • biomarkers • advanced targeted therapiesResearch Interests
My research focuses on inflammatory bowel diseases, a group of immune-mediated inflammatory disorders marked by chronic inflammation of the intestinal mucosa. I investigate the role of innate and adaptive immunity and am interested in a variety of models to study the causes and mechanisms of these diseases, including studying the postoperative relapse – why some patients experience recurrence while others do not -, as well as response to advanced therapies. The overarching goals of my work are to better characterize disease subtypes, identify biomarkers that predict therapeutic outcomes, and uncover optimal combinations and novel therapeutic targets.Team Members
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Latest Publications
- Allez, M., Bak, M. T. J., Brand, S., Diebakate-Scordamaglia, L., Capelle, E., Seksik, P., Nancey, S., Gornet, J.-M., Buisson, A., Carbonnel, F., Peyrin-Biroulet, L., Louis, E., Hébuterne, X., Serrero, M., Bourreille, A., Treton, X., Wils, P., Fumery, M., Blanc, P., Uzzan, M., Sokol, H., Barnich, N., Kirchgesner, J., Colombel, J.-F., Maggiori, L., Bezault, M., Silverberg, M. S., De Vries, A. C., Lambert, J. & Hammoudi, N. (2026). Development and External Validation of a Predictive Model for Postoperative Recurrence of Crohn's Disease in the Biologic Era. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
- Verstockt, S., Schwärzler, J., Willeit, P., Bislenghi, G., Meyer, M., Mayr, L., Machiels, K., De Hertogh, G., Lenfant, M., Scheffauer, L., Grabherr, F., Jans, D. S., Abdurahiman, S., Cleynen, I., Jukic, A., Zundel, L., Moser, P., Forer, L., Witsch-Baumgartner, M., Ferrante, M., Sabino, J., D'Hoore, A., Hess, M., Kaser, A., Blumberg, R. S., Koch, R., Le Bourhis, L., Hammoudi, N., Cazals-Hatem, D., Vermeire, S., Tilg, H., Allez, M., Verstockt, B. & Adolph, T. E. (2026). Identification of a Druggable Target That Predicts Postoperative Crohn's Disease Recurrence. Gastroenterology.
- Dubois, L., Chaussard, A., Seksik, P., Nancey, S., Nachury, M., Treton, X., Buisson, A., Carbonnel, F., Fumery, M., Peyrin-Biroulet, L., Boureille, A., Hébuterne, X., Serrero, M., Louis, E., Blanc, P., Brot, L., Rolhion, N., Vermeire, S., Manichanh, C., Fossmark, R., Bezault, M., Uzzan, M., REMIND Group, Allez, M. & Sokol, H. (2026). Uncovering the Dynamics of Mucosa-Associated Microbiota in Postoperative Recurrence of Crohn's Disease. Gastroenterology.
- Gendard, M., Seksik, P., Stefanescu, C., Meyer, A., Nachury, M., Nancey, S., Savoye, G., Allez, M., Laharie, D., Serrero, M., Franchimont, D., Mathieu, N., Fumery, M., Vuitton, L., Nahon, S., Gilletta, C., Rouillon, C., Nuzzo, A., Berre, C. L., Caron, B., Buisson, A., Amil, M., Charkaoui, M., Cadiot, G., Caillo, L., Simon, M., Reenaers, C., Hébuterne, X., Plastaras, L., Atanasiu, C., Kwiatek, S., Uzzan, M., Pelletier, A.-L., Benezech, A., Vidon, M., Goutorbe, F., Geyl, S., Cellier, C., Montuclard, C., Moussata, D., Altwegg, R., Amiot, A. & GETAID-physical-activity-in-IBD study group (2026). Association between physical activity with disease activity and functional disability in patients with inflammatory bowel disease. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 58, p. 479-487.
- Fontaine, L., Seksik, P., Stefanescu, C., Nachury, M., Nancey, S., Savoye, G., Allez, M., Altwegg, R., Laharie, D., Serrero, M., Franchimont, D., Mathieu, N., Fumery, M., Vuitton, L., Nahon, S., Gilletta, C., Rouillon, C., Nuzzo, A., Bourreille, A., Caron, B., Buisson, A., Amil, M., Charkaoui, M., Cadiot, G., Caillo, L., Simon, M., Reenaers, C., Hébuterne, X., Plastaras, L., Atanasiu, C., Kwiatek, S., Uzzan, M., Pelletier, A.-L., Benezech, A., Vidon, M., Goutorbe, F., Geyl, S., Cellier, C., Montuclard, C., Moussata, D., Amiot, A., Meyer, A. & GETAID-Diet-in-IBD study group (2026). Diet and clinical remission in patients with inflammatory bowel disease: A multicenter cross-sectional study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 58, p. 220-231.
- Zhao, B., Su, T.-Y., Wang, J., Islam, Q. S., Song, K., Huang, S. K., Allez, M., Fonseca, G. J., Baglole, C. J. & Ding, J. (2025). DENetwork unveils non-differentially expressed genes with functional relevance across conditions through information flow perturbation. Nucleic acids research, vol. 53.
- Amiot, A., Kirchgesner, J., Alric, H., Tréton, X., Uzzan, M., Hammoudi, N., Allez, M., Bresteau, C., Bouhnik, Y., Seksik, P., Carbonnel, F. & Meyer, A. (2025). Five-year effectiveness of either ustekinumab or vedolizumab in 239 patients with Crohn's disease refractory to anti-tumour necrosis factor. Clinics and research in hepatology and gastroenterology, p. 102741.
- Shehab, M., Alrashed, O., Alrashed, F., Alyousefi, R., Zoughlami, A., Lakatos, P., Allez, M., Jairath, V., Regueiro, M. & Bessissow, T. (2026). Comparative Efficacy of Medical Therapies in Reducing the Risk of Postoperative Recurrence in Crohn's Disease: A Systematic Review and Network Meta-Analysis. Inflammatory bowel diseases, vol. 32, p. 25-38.
- Veyssière, M., Hammoudi, N., Le Bourhis, L., Hassid, D., Bonnet, J., Tran Minh, M.-L., Baudry, C., Gornet, J.-M., Chardiny, V., Seksik, P., Nancey, S., Carbonnel, F., Treton, X., Wils, P., Buisson, A., Boureille, A., Hébuterne, X., Serrero, M., Fumery, M., Louis, E., Blanc, P., Peyrin-Biroulet, L., Bezault, M., Soumelis, V. & Allez, M. (2025). Blood proteomic signatures associated with disease activity in Inflammatory Bowel Diseases. Journal of Crohn's & colitis, vol. 19.
- Kövilein, J., Sorbie, A., Khaloian, S., Küntzel, V., von Stern, M., Ahmed, M., Jarosch, S., Remke, M., Metwaly, A., Reuss, E. M., Busch, D. H., Allez, M., Steiger, K., Schraml, B., Coleman, O. I. & Haller, D. (2025). Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer. Journal of Crohn's & colitis, vol. 19.
