Lab Information
Matthieu Allez (MD/PhD)
InvestigatorClinical Research Unit
Department of Medicine (McGill)
Research Profile
Keywords
Translational IBD research • gene expression • T cell repertoire • multiomic analysis • biomarkers • advanced targeted therapiesResearch Interests
My research focuses on inflammatory bowel diseases, a group of immune-mediated inflammatory disorders marked by chronic inflammation of the intestinal mucosa. I investigate the role of innate and adaptive immunity and am interested in a variety of models to study the causes and mechanisms of these diseases, including studying the postoperative relapse – why some patients experience recurrence while others do not -, as well as response to advanced therapies. The overarching goals of my work are to better characterize disease subtypes, identify biomarkers that predict therapeutic outcomes, and uncover optimal combinations and novel therapeutic targets.Team Members
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Latest Publications
- Carbonnel, F., Barnich, N., Lepage, P., Hébuterne, X., Michiels, C., Gilletta, C., Wils, P., Laharie, D., Altwegg, R., Allez, M., Bouhnik, Y., Meyer, A., Breton, C., Agostini, H., Molinari, D., Balfour Sartor, R., Mary, J. Y., Colombel, J. F., Chevarin, C., Faure, F., Walter-Petrich, A., Chevret, S. & Buisson, A. (2025). A Randomized Controlled Trial Of Antibiotics Targeting Adherent And Invasive Escherichia Coli (Aiec) Vs Placebo In Crohn's Disease: The Teorem Trial. Journal of Crohn's & colitis, vol. 19.
- Hanžel, J., Solitano, V., Vuyyuru, S. K., Panaccione, R., Sands, B. E., Peyrin-Biroulet, L., Danese, S., D'Haens, G. R., Atreya, R., Allez, M., Bernstein, C. N., Bossuyt, P., Bressler, B., Bryant, R. V., Cohen, B. L., Colombel, J.-F., D'Amico, F., Dignass, A., Dubinsky, M., Fleshner, P., Gearry, R. B., Hanauer, S. B., Hart, A. L., Kayal, M., Kucharzik, T., Lakatos, P. L., Louis, E., Magro, F., Narula, N., Leong, R. W., Panés, J., Raine, T., Ran, Z., Regueiro, M. D., Reinisch, W., Singh, S., Steinhart, A. H., Travis, S., Ungaro, R. C., Janneke van der Woude, C., Yamamoto, T., Ahuja, V., Rubin, D. T., Dulai, P. S., Cornfield, L. J., Hogan, M., Sandborn, W. J., Feagan, B. G., Jairath, V. & Ma, C. (2025). An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease. Gastroenterology.
- Linggi, B., Azucena, S., Steere, B., Verstockt, B., Alsoud, D., Casero, D., McGovern, D., Chan, E., Smith, M. I., Ungaro, F., Rieder, F., Aden, K., Shackelton, L. M., Massimino, L., Neurath, M., Allez, M., Atreya, R., Snapper, S. B., Raine, T., Ahuja, V., Haberman, Y., Feagan, B. G., Jairath, V. & Vande Casteele, N. (2025). Expert recommendations to standardize transcriptomic analysis in inflammatory bowel disease clinical trials. Journal of Crohn's & colitis, vol. 19.
- Sachen, K. L., Hammaker, D., Sarabia, I., Stoveken, B., Hartman, J., Leppard, K. L., Manieri, N. A., Bao, P., Greving, C., Lacy, E. R., DuPrie, M., Wertheimer, J., Deming, J. D., Brown, J., Hart, A., Li, H. H., Freeman, T. C., Keyes, B., Kohler, K., White, I., Karpowich, N., Steele, R., Elloso, M. M., Fakharzadeh, S., Goyal, K., Lavie, F., Abreu, M. T., Allez, M., Atreya, R., Bissonnette, R., Eyerich, K., Krueger, J. G., McGonagle, D., McInnes, I. B., Ritchlin, C. & Fourie, A. M. (2025). Guselkumab binding to CD64+ IL-23-producing myeloid cells enhances potency for neutralizing IL-23 signaling. Frontiers in immunology, vol. 16, p. 1532852.
- Pesesky, M., Bharanikumar, R., Le Bourhis, L., ElAbd, H., Rosati, E., Carty, C. L., Singh, N., Bokemeyer, B., Schreiber, S., Görg, S., Noceda, M. G., Chapfuwa, P., Gittelman, R. M., May, D., Dines, J. N., Zhou, W., Kaplan, I. M., Snyder, T. M., Jabran Zahid, H., Greissl, J., Chen-Harris, H., Howie, B., Franke, A., Robins, H. S. & Allez, M. (2025). Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases. Journal of Crohn's & colitis.
- Richard, N., Amiot, A., Seksik, P., Altwegg, R., Laharie, D., Vuitton, L., Nachury, M., Bouguen, G., Nancey, S., Gilletta, C., Rouilon, C., Coffin, B., Allez, M., Buisson, A., Le Berre, C., Uzzan, M., Caillo, L., Pelletier, A.-L., Peyrin-Biroulet, L., Fumery, M. & GETAID (2025). Effectiveness and Safety of Upadacitinib Induction Therapy for 223 Patients With Crohn's Disease: A GETAID Multicentre Cohort Study. Alimentary pharmacology & therapeutics, vol. 61, p. 1662-1670.
- Hammoudi, N. & Allez, M. (2025). Vedolizumab for prevention of recurrence of Crohn's disease. The lancet. Gastroenterology & hepatology, vol. 10, p. 193.
- Ten Bokkel Huinink, S., Bak, M. T. J., Beelen, E. M. J., Erler, N. S., Silverberg, M. S., Allez, M., Hoentjen, F., Bodelier, A. G. L., Dijkstra, G., Romberg-Camps, M., de Boer, N. K. H., Stassen, L. P. S., van der Meulen-de Jong, A. E., West, R. L., van der Woude, C. J., van Ruler, O., de Vries, A. C. & Dutch Initiative on Crohn and Colitis (ICC) (2025). The Impact of Postoperative Prophylactic Medication on Long-Term Surgical, Severe Endoscopic and Endoscopic or Radiologic Recurrence Following Primary Ileocecal Resection in Patients With Crohn's Disease. Alimentary pharmacology & therapeutics, vol. 61, p. 1019-1031.
- Amiot, A., Seksik, P., Meyer, A., Stefanescu, C., Wils, P., Altwegg, R., Vuitton, L., Plastaras, L., Nicolau, A., Pereira, B., Duveau, N., Laharie, D., Mboup, B., Boualit, M., Allez, M., Rajca, S., Chanteloup, E., Bouguen, G., Bazin, T., Goutorbe, F., Richard, N., Moussata, D., Vicaut, E. & Peyrin-Biroulet, L. (2025). Top-down infliximab plus azathioprine versus azathioprine alone in patients with acute severe ulcerative colitis responsive to intravenous steroids: a parallel, open-label randomised controlled trial, the ACTIVE trial. Gut, vol. 74, p. 197-205.
- Mancheron, A., Dumas, A., Nion Larmurier, I., Landman, C., Peyrin Biroulet, L., Caron, B., Baudry, C., Allez, M., Serrero, M., Yahioune, D., Nancey, S., Roman, C., Ducleau-Loras, R., Coopman, S., Boizeau, P., Husson, M., Sable, S., Tarbet, I., Devos, C., Bourmaud, A. & Martinez-Vinson, C. (2025). Development and Validation of a Sexual Quality of Life Score for Youths With Inflammatory Bowel Disease. Journal of Crohn's & colitis, vol. 19.
See also
