Lab Information
Danielle Malo (PhD)
InvestigatorMcGill University
Department of Human Genetics (McGill)
Research Profile
Keywords
Salmonella • typhoid • complex disease • animal model • mutagenesisResearch Interests
My research focuses on identifying and characterizing genes involved in the host immune response to pathogenic Salmonella using mouse models of the disease. Salmonella are ubiquitous, facultative intracellular Gram-negative bacteria causing human diseases (typhoid fever and salmonellosis) of increasingly important public health concern both in developed and developing countries. Salmonella Typhi is the causative agent of typhoid fever and Salmonella Typhimurium and Enteritidis are associated with frequent outbreaks of food-borne gastroenteritis (salmonellosis). Multidrug resistant non-typhoidal Salmonella (NTS) infections are also increasingly frequent in developing countries. My lab is using different models of infection (systemic, chronic carriage and intestinal infection) and genetic approaches (positional cloning of Mendelian and complex phenotypes and chemical mutagenesis) to study the complex mechanisms underlying the host response to Salmonella infection.Team Members
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Latest Publications
- Rufyikiri, A. S., Martinez, R., Addo, P. W., Wu, B.-S., Yousefi, M., Malo, D., Orsat, V., Vidal, S. M., Fritz, J. H., MacPherson, S. & Lefsrud, M. (2024). Germicidal efficacy of continuous and pulsed ultraviolet-C radiation on pathogen models and SARS-CoV-2. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, vol. 23, p. 339-354.
- Neehus, A.-L., Carey, B., Landekic, M., Panikulam, P., Deutsch, G., Ogishi, M., Arango-Franco, C. A., Philippot, Q., Modaresi, M., Mohammadzadeh, I., Corcini Berndt, M., Rinchai, D., Le Voyer, T., Rosain, J., Momenilandi, M., Martin-Fernandez, M., Khan, T., Bohlen, J., Han, J. E., Deslys, A., Bernard, M., Gajardo-Carrasco, T., Soudée, C., Le Floc'h, C., Migaud, M., Seeleuthner, Y., Jang, M.-S., Nikolouli, E., Seyedpour, S., Begueret, H., Emile, J.-F., Le Guen, P., Tavazzi, G., Colombo, C. N. J., Marzani, F. C., Angelini, M., Trespidi, F., Ghirardello, S., Alipour, N., Molitor, A., Carapito, R., Mazloomrezaei, M., Rokni-Zadeh, H., Changi-Ashtiani, M., Brouzes, C., Vargas, P., Borghesi, A., Lachmann, N., Bahram, S., Crestani, B., Pahari, S., Schlesinger, L. S., Marr, N., Bugonovic, D., Boisson-Dupuis, S., Béziat, V., Abel, L., Borie, R., Young, L. R., Deterding, R., Shahrooei, M., Rezaei, N., Parvaneh, N., Craven, D., Gros, P., Malo, D., Sepulveda, F. E., Nogee, L. M., Aladjidi, N., Trapnell, B. C., Casanova, J.-L. & Bustamante, J. (2024). Human inherited CCR2 deficiency underlies progressive polycystic lung disease. Cell, vol. 187, p. 390-408.e23.
- Kim, J. E. J., Tung, L. T., Jiang, R. R., Yousefi, M., Liang, Y., Malo, D., Vidal, S. M. & Nijnik, A. (2023). Dysregulation of B lymphocyte development in the SKG mouse model of rheumatoid arthritis. Immunology, vol. 170, p. 553-566.
- Cavestri, C., Savard, P., Fliss, I., Emond-Rhéault, J.-G., Hamel, J., Kukavica-Ibrulj, I., Boyle, B., Daigle, F., Malo, D., Bekal, S., Harris, L. J., Levesque, R. C., Goodridge, L. & LaPointe, G. (2022). Salmonella enterica subsp. enterica virulence potential can be linked to higher survival within a dynamic in vitro human gastrointestinal model. Food microbiology, vol. 101, p. 103877.
- Emond-Rheault, J.-G., Hamel, J., Jeukens, J., Freschi, L., Kukavica-Ibrulj, I., Boyle, B., Tamber, S., Malo, D., Franz, E., Burnett, E., Daigle, F., Arya, G., Sanderson, K., Wiedmann, M., Slawson, R. M., Weadge, J. T., Stephan, R., Bekal, S., Gruenheid, S., Goodridge, L. D. & Levesque, R. C. (2020). The Salmonella enterica Plasmidome as a Reservoir of Antibiotic Resistance. Microorganisms, vol. 8.
- Crouse, A., Schramm, C., Emond-Rheault, J.-G., Herod, A., Kerhoas, M., Rohde, J., Gruenheid, S., Kukavica-Ibrulj, I., Boyle, B., Greenwood, C. M. T., Goodridge, L. D., Garduno, R., Levesque, R. C., Malo, D. & Daigle, F. (2020). Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors of Salmonella Virulence. mSphere, vol. 5.
- Zhang, J., Teh, M., Kim, J., Eva, M. M., Cayrol, R., Meade, R., Nijnik, A., Montagutelli, X., Malo, D. & Jaubert, J. (2019). A Loss-of-Function Mutation in the Integrin Alpha L (Itgal) Gene Contributes to Susceptibility to Salmonella enterica Serovar Typhimurium Infection in Collaborative Cross Strain CC042. Infection and immunity, vol. 88.
- Yuki, K. E., Marei, H., Fiskin, E., Eva, M. M., Gopal, A. A., Schwartzentruber, J. A., Majewski, J., Cellier, M., Mandl, J. N., Vidal, S. M., Malo, D. & Dikic, I. (2019). CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Nature microbiology, vol. 4, p. 1516-1531.
- Kang, E., Crouse, A., Chevallier, L., Pontier, S. M., Alzahrani, A., Silué, N., Campbell-Valois, F.-X., Montagutelli, X., Gruenheid, S. & Malo, D. (2018). Enterobacteria and host resistance to infection. Mammalian genome : official journal of the International Mammalian Genome Society, vol. 29, p. 558-576.
- Zhang, J., Malo, D., Mott, R., Panthier, J.-J., Montagutelli, X. & Jaubert, J. (2018). Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice. BMC genomics, vol. 19, p. 303.
See also
