Lab Information

Laurence Chapuy (MD/PhD)

Associate Investigator
Clinical Research Unit
Department of Medicine (McGill)

Research Profile

 Fundamental: 50%
 Clinical: 50%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Inflammatory bowel disease • mucosal immunology • innate immunity • mononuclear phagocytes • fibrosis

Research Interests

My research focuses on immunological mechanisms underlying inflammatory bowel diseases. I study the role of innate immune cells, called mononuclear phagocytes, in the inflammatory and scar tissues of patients with Crohn's disease and ulcerative colitis.


Team Members

Name Position

Latest Publications

  1. Chapuy, L., Leduc, B., Godin, D., Damphousse, A., Patey, N., Dal Soglio, D., Jantchou, P. & Deslandres, C. (2023). Phenotype and outcomes of very early onset and early onset inflammatory bowel diseases in a Montreal pediatric cohort. Frontiers in pediatrics, vol. 11, p. 1157025.
  2. Sarfati, M., Chapuy, L. & Mehta, H. (2022). Revisiting the disease specificity and nomenclature of ficolin-1-positive monocyte-derived dendritic cells in diffuse cutaneous systemic sclerosis: comment on the article by Xue et al. Arthritis & rheumatology (Hoboken, N.J.), vol. 74, p. 1721-1722.
  3. Bsat, M., Chapuy, L., Rubio, M. & Sarfati, M. (2020). A two-step human culture system replicates intestinal monocyte maturation cascade: Conversion of tissue-like inflammatory monocytes into macrophages. European journal of immunology, vol. 50, p. 1676-1690.
  4. Chapuy, L. & Sarfati, M. (2020). Single-Cell Protein and RNA Expression Analysis of Mononuclear Phagocytes in Intestinal Mucosa and Mesenteric Lymph Nodes of Ulcerative Colitis and Crohn's Disease Patients. Cells, vol. 9.
  5. Chapuy, L., Bsat, M., Sarkizova, S., Rubio, M., Therrien, A., Wassef, E., Bouin, M., Orlicka, K., Weber, A., Hacohen, N., Villani, A.-C. & Sarfati, M. (2020). Correction: Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease. Mucosal immunology, vol. 13, p. 381.
  6. Chapuy, L., Bsat, M., Rubio, M., Harvey, F., Motta, V., Schwenter, F., Wassef, R., Richard, C., Deslandres, C., Nguyen, B. N., Soucy, G., Hacohen, N., Fritz, J., Villani, A.-C., Mehta, H. & Sarfati, M. (2020). Transcriptomic Analysis and High-dimensional Phenotypic Mapping of Mononuclear Phagocytes in Mesenteric Lymph Nodes Reveal Differences Between Ulcerative Colitis and Crohn's Disease. Journal of Crohn's & colitis, vol. 14, p. 393-405.
  7. Chapuy, L., Bsat, M., Rubio, M., Sarkizova, S., Therrien, A., Bouin, M., Orlicka, K., Weber, A., Soucy, G., Villani, A.-C. & Sarfati, M. (2020). IL-12 and Mucosal CD14+ Monocyte-Like Cells Induce IL-8 in Colonic Memory CD4+ T Cells of Patients With Ulcerative Colitis but not Crohn's Disease. Journal of Crohn's & colitis, vol. 14, p. 79-95.
  8. Bsat, M., Chapuy, L., Rubio, M., Wassef, R., Richard, C., Schwenter, F., Loungnarath, R., Soucy, G., Mehta, H. & Sarfati, M. (2019). Differential Pathogenic Th17 Profile in Mesenteric Lymph Nodes of Crohn's Disease and Ulcerative Colitis Patients. Frontiers in immunology, vol. 10, p. 1177.
  9. Chapuy, L., Bsat, M., Sarkizova, S., Rubio, M., Therrien, A., Wassef, E., Bouin, M., Orlicka, K., Weber, A., Hacohen, N., Villani, A.-C. & Sarfati, M. (2019). Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease. Mucosal immunology, vol. 12, p. 703-719.
  10. Therrien, A., Chapuy, L., Bsat, M., Rubio, M., Bernard, G., Arslanian, E., Orlicka, K., Weber, A., Panzini, B.-P., Dorais, J., Bernard, E.-J., Soucy, G., Bouin, M. & Sarfati, M. (2019). Recruitment of activated neutrophils correlates with disease severity in adult Crohn's disease. Clinical and experimental immunology, vol. 195, p. 251-264.
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