Lab Information
Danuta Radzioch (PhD)
Senior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Inflammation • animal models • translational research • lipid imbalance • gene expression regulationResearch Interests
My research focuses on the molecular mechanisms involved in the regulation of inflammatory response in asthma, cystic fibrosis and cancer. It involves preclinical studies testing novel anti-inflammatory drugs on cystic fibrosis lung disease, allergic asthma and colon cancer. Our research team has discovered pharmacological intervention which enables to normalize fatty acids metabolism distortion during chronic bacterial infections in cystic fibrosis, chronic allergic responses, and acute spinal cord injuries leading to permanent motor dysfunction. My laboratory has developed mouse models of cystic fibrosis lung disease, mouse models of allergic asthma, genetically controlled airway hyperresponsiveness and atopy, and mouse models of colon cancer. Our research also explores the role of chromatin remodelling in the regulation of transcriptional regulation and the mechanisms of posttranscriptional control of genes involved in the control of inflammatory response. We have identified drugs and therapies which can improve Cystic fibrosis lung disease and allergic asthma. One of the drugs are working on has received an orphan drug designation from the FDA and we are in the final stage of preparing for a Phase 1b clinical trial to test its safety and therapeutic potential in patients suffering from cystic fibrosis.Team Members
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Latest Publications
- Konstan, M. W., Polineni, D., Chmiel, J. F., Bilodeau, L., Middleton, P. G., Matouk, E., Houle, J.-M., Pislariu, R., Colin, P., Kianicka, I., Potvin, D., Radzioch, D., Kotsimbos, T., Zuckerman, J. B., Nasr, S. Z., Liou, T. G., Lands, L. C. & study Investigators (2024). Efficacy and safety of LAU-7b in a Phase 2 trial in adults with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
- Ondra, M., Lenart, L., Centorame, A., Dumut, D. C., He, A., Zaidi, S. S. Z., Hanrahan, J. W., De Sanctis, J. B., Radzioch, D. & Hajduch, M. (2024). CRISPR/Cas9 bioluminescence-based assay for monitoring CFTR trafficking to the plasma membrane. Life science alliance, vol. 7.
- Garić, D., Dumut, D. C., Centorame, A. & Radzioch, D. (2023). Western Blotting with Fast SDS-PAGE and Semi-Dry Protein Transfer. Current protocols, vol. 3, p. e833.
- Dumut, D. C., Garić, D., Centorame, A. & Radzioch, D. (2022). The gradient-like separation and reduced running time with Tris-Tricine-HEPES buffer for SDS-PAGE. Analytical biochemistry, vol. 653, p. 114789.
- Centorame, A., Dumut, D. C., Youssef, M., Ondra, M., Kianicka, I., Shah, J., Paun, R. A., Ozdian, T., Hanrahan, J. W., Gusev, E., Petrof, B., Hajduch, M., Pislariu, R., De Sanctis, J. B. & Radzioch, D. (2022). Treatment With LAU-7b Complements CFTR Modulator Therapy by Improving Lung Physiology and Normalizing Lipid Imbalance Associated With CF Lung Disease. Frontiers in pharmacology, vol. 13, p. 876842.
- Gusev, E., Liang, F., Bhattarai, S., Broering, F. E., Leduc-Gaudet, J.-P., Hussain, S. N., Radzioch, D. & Petrof, B. J. (2022). Characterization of skeletal muscle wasting pathways in diaphragm and limb muscles of cystic fibrosis mice. American journal of physiology. Regulatory, integrative and comparative physiology, vol. 322, p. R551-R561.
- Paun, R. A., Dumut, D. C., Centorame, A., Thuraisingam, T., Hajduch, M., Mistrik, M., Dzubak, P., De Sanctis, J. B., Radzioch, D. & Tabrizian, M. (2022). One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy. Pharmaceutics, vol. 14.
- Radzioch, D., Giera, M. & De Sanctis, J. B. (2021). Editorial: Quo Vadis Lipid Mediators - Lipid Mediators Implication in Inflammation and Chronic Inflammatory Diseases. Frontiers in immunology, vol. 12, p. 699276.
- Hennemann, L. C., LaFayette, S. L., Malet, J. K., Bortolotti, P., Yang, T., McKay, G. A., Houle, D., Radzioch, D., Rousseau, S. & Nguyen, D. (2021). LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation. PLoS pathogens, vol. 17, p. e1009375.
- Veltman, M., De Sanctis, J. B., Stolarczyk, M., Klymiuk, N., Bähr, A., Brouwer, R. W., Oole, E., Shah, J., Ozdian, T., Liao, J., Martini, C., Radzioch, D., Hanrahan, J. W. & Scholte, B. J. (2021). CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells. Frontiers in physiology, vol. 12, p. 619442.
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