Lab Information

Chen Liang (PhD)

Associate Investigator
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 100%
 Clinical: 0%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

HIV • COVID-19 • SARS-CoV • innate immunity • interferon • antivirals

Research Interests

My research aims to understand the host innate immune responses to viral infections. My team uses the findings to understand viral pathogenesis and transmission and to guide the development of effective antiviral therapeutics. Specifically, we investigate how host cells produce antiviral interferons in response to infections by HIV or SARS-CoV-2, and how these two highly pathogenic viruses overcome and evade this first line of host defense. We are dedicated to the discovery of new HIV treatments and the compounds that can effectively inhibit SARS-CoV-2 and thus cure COVID-19. My lab has also pioneered the application of the CRISPR gene editing tool in curing HIV infection.


Team Members

Name Position

Latest Publications

  1. Zhao, J., Wang, J., Pang, X., Liu, Z., Li, Q., Yi, D., Zhang, Y., Fang, X., Zhang, T., Zhou, R., Zhang, T., Guo, Z., Liu, W., Li, X., Liang, C., Deng, T., Guo, F., Yu, L. & Cen, S. (2022). An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA. Nature communications, vol. 13, p. 2079.
  2. Liu, X., Wei, L., Xu, F., Zhao, F., Huang, Y., Fan, Z., Mei, S., Hu, Y., Zhai, L., Guo, J., Zheng, A., Cen, S., Liang, C. & Guo, F. (2022). SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response. Science signaling, vol. 15, p. eabg8744.
  3. Huang, Y., Xu, F., Mei, S., Liu, X., Zhao, F., Wei, L., Fan, Z., Hu, Y., Wang, L., Ai, B., Cen, S., Liang, C. & Guo, F. (2022). MxB inhibits long interspersed element type 1 retrotransposition. PLoS genetics, vol. 18, p. e1010034.
  4. Liu, X., Xu, F., Ren, L., Zhao, F., Huang, Y., Wei, L., Wang, Y., Wang, C., Fan, Z., Mei, S., Song, J., Zhao, Z., Cen, S., Liang, C., Wang, J. & Guo, F. (2021). MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes. Nature communications, vol. 12, p. 4427.
  5. Huang, Y., McLean, M., Liang, C. & Guo, F. (2021). Protocol for nuclear export signal characterization of cGAS in mammalian cells. STAR protocols, vol. 2, p. 100649.
  6. Chai, K., Wang, Z., Pan, Q., Tan, J., Qiao, W. & Liang, C. (2021). Effect of Different Nuclear Localization Signals on the Subcellular Localization and Anti-HIV-1 Function of the MxB Protein. Frontiers in microbiology, vol. 12, p. 675201.
  7. Cai, T., Yu, Z., Wang, Z., Liang, C. & Richard, S. (2021). Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication. The Journal of biological chemistry, vol. 297, p. 100821.
  8. Zhao, J., Guo, S., Yi, D., Li, Q., Ma, L., Zhang, Y., Wang, J., Li, X., Guo, F., Lin, R., Liang, C., Liu, Z. & Cen, S. (2021). A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase. Antiviral research, vol. 190, p. 105078.
  9. Ma, L., Chen, S., Wang, Z., Guo, S., Zhao, J., Yi, D., Li, Q., Liu, Z., Guo, F., Li, X., Jia, P., Ding, J., Liang, C. & Cen, S. (2021). The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR. Virologica Sinica, vol. 36, p. 796-809.
  10. Xu, F., Liu, X., Zhang, D., Zhao, F., Fan, Z., Hu, S., Mei, S., Huang, Y., Sun, H., Wei, L., Guo, L., Wang, J., Cen, S., Liang, C. & Guo, F. (2021). The Engineered MARCH8-Resistant Vesicular Stomatitis Virus Glycoprotein Enhances Lentiviral Vector Transduction. Human gene therapy, vol. 32, p. 936-948.
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See also

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Silvia
Vidal


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