Description of position
Please note that this position is outside the IDIGH Program, but at the same institution. Dr. Salman Qureshi is a collaborator of the IDIGH Program.
We are looking to recruit a postdoctoral fellow to join the laboratory of Dr. Salman Qureshi at the Research Institute of the McGill University Health Centre, a research institute affiliated with the McGill University. The CIHR-funded research project aims to advance knowledge of fungal disease pathogenesis through systematic analysis of cells, molecular pathways, and genes in a clinically relevant mouse model of Cryptococcus neoformans (C. neoformans) infection. The fundamental insights arising from these studies will pave the way for improved management of invasive fungal disease.
Dr. Qureshi’s laboratory has identified two independent chromosomal sub-intervals that significantly reduce fungal burden in the lung and brain, but have distinctly different consequences for the host infected with C. neoformans. Specifically, one of these intervals protects against progressive fungal infection, whereas the other is associated with severe inflammation that models the immune reconstitution inflammatory syndrome (IRIS). IRIS is a life-threatening condition observed during C. neoformans therapy in humans. We are now using highly complementary functional and genetic strategies to identify and characterize the cellular/molecular mechanisms and causal genes that underlie these divergent host responses to C. neoformans infection.
Dr. Qureshi’s laboratory is located in the Centre for Translational Biology (CTB) of the Research Institute of the MUHC (http://rimuhc.ca/-/salman-qureshi-md), a state-of-the-art facility opened in 2015 that provides access to multiple advanced technical platform facilities and an excellent animal facility. The CTB is adjacent to the hospital, providing ready access to patient clinics. Dr. Qureshi’s laboratory is a member of the Translational Research in Respiratory Diseases Program and the Meakins-Christie Laboratories, as well as the McGill University Research Centre on Complex Traits, all of which are collaborative, multidisciplinary research groups.
The postdoctoral fellowship position is for a period of three years. Dr. Qureshi will provide salary for the first year, but will encourage and support applications for internal and external fellowship funding for subsequent years.
Qualifications / Required skills
The applicant should have a Ph.D. degree (obtained within the past 1-3 years), and a strong background in immunology and molecular biology. The applicant should also have expertise in flow cytometry, cellular assays, molecular biological methods (e.g., PCR, RT-PCR), and working with mice. Salary will be negotiated dependent on experience.
Province: Montreal, Quebec
Position: Post-doctoral fellowship
Posted: May 2019